Results 51 to 60 of about 17,670,994 (229)

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Extranodal Marginal Zone B-cell Lymphoma of the Ocular Adnexa [PDF]

Cancer Control, 2016
Low-grade B-cell lymphomas located around the eye present unique challenges in diagnosis and treatment. Extranodal marginal zone B-cell lymphoma is the most common lymphoma of the ocular adnexa (conjunctiva, orbit, lacrimal gland, and eyelid).A systematic search of the relevant literature was performed.
Jean, Guffey Johnson, Lauren A, Terpak, Curtis E, Margo, Reza, Setoodeh   +3 more
openaire   +2 more sources

Spatially Resolved Metabolomics of Optimal Cutting Temperature (OCT) Compound‐Embedded Tumors

International Journal of Cancer, EarlyView.
ABSTRACT Mass spectrometry imaging (MSI) is emerging as a powerful tool for uncovering the distribution of metabolites in the tumor microenvironment and studying tumor metabolism in vivo. To date, MSI of biobanked tissues contextualized by patient data has been limited to peptides, proteins, and glycans—with few examples for metabolites.
Joseph Monaghan, Nicholas Woytowich, Tian Zhao, Kiera Nguyen, Emily Mahony, Julian J. Lum, Kyle D. Duncan   +6 more
wiley   +1 more source

Mucosa associated lymphoid tissue lymphoma of the thyroid gland: a case report and literature review = MALT linfoma della tiroide: caso clinico e revisione della letteratura [PDF]

, 2012
Mucosa associated lymphoid tissue (MALT) lymphomas are low-grade, non-Hodgkin’s B cell lymphomas, mainly occurring in the gastrointestinal tract, but also in other tissues.
Paliogiannis, Panagiotis, Pulighe, Fabio, Pisano, Ilia Patrizio, Trignano, Mario, Attene, Federico, Scognamillo, Fabrizio   +5 more
core  

Marginal B-cell lymphoma: A 10-year retrospective study at national institute of hematology and blood transfusion, Vietnam

SAGE Open Medicine
Objective: The prognostic factors of patients diagnosed with marginal zone B-cell lymphoma at the National Institute of Hematology and Blood Transfusion between January 2014 and January 2024 were analyzed.
Binh Duc Vu, Hung Quang Nguyen, Chiem Quang Le, Cuong Ba Nguyen, Tuong Quang Le, Anh Vu-Bao Nguyen, Thanh Hoang Nguyen, Tai Phu Le, Hieu Van Nguyen   +8 more
doaj   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

A case of primary cutaneous marginal zone B-cell lymphoma

Pifu-xingbing zhenliaoxue zazhi
We report a case of primary cutaneous marginal zone B-cell lymphoma. A 23-year-old male presented with red nodules on his back for 5 years. Physical examination revealed multiple demarcated red nodules on the back, sized 5 mm×5 mm to 10 mm×15 mm, with ...
HUANG Jiamin, SUN Zhaojun, REN Haiyue
doaj   +1 more source

Marginal Zone B-Cell Lymphoma in Children and Young Adults [PDF]

The American Journal of Surgical Pathology, 2003
We describe the clinicopathologic findings of 48 cases of marginal zone B-cell lymphoma (MZL) in children and young adults, a disease that has been recognized previously only rarely in this age group. Patients ranged in age from 2 to 29 years, with pediatric patients (< or =18 years) comprising 52% of the cases. As in adults, both primary nodal (N) and
Lekidelu, Taddesse-Heath, Stefania, Pittaluga, Lynn, Sorbara, Mary, Bussey, Mark, Raffeld, Elaine S, Jaffe   +5 more
openaire   +2 more sources

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Cutaneous Rosai‐Dorfman Disease With MAP2K1 Mutation Treated With Encorafenib and Binimetinib

JEADV Clinical Practice, EarlyView.
ABSTRACT Rosai‐Dorfman disease (RDD) is a rare histiocytic disorder with unifocal to multisystemic involvement. Activating mutations in the MAPK/ERK pathway can occur in up to 50% of RDD cases. We report a case of cutaneous RDD (C‐RDD) with facial and truncal lesions harboring an activating MAP2K1 (MEK1) mutation that showed a complete response to a ...
Melike Ak, Reinhard Dummer, Egle Ramelyte   +2 more
wiley   +1 more source