Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe +5 more
wiley +1 more source
When "Metastatic Disease" Is Not Metastatic: Diffuse Large B-cell Lymphoma Presenting With a Perisplenic Mass, Pulmonary Masses, Pleural Effusion, and Retroperitoneal Lymphadenopathy. [PDF]
Furlan Silva Fabri R +7 more
europepmc +1 more source
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
Transcriptomic Study of Diffuse Large B-Cell Lymphoma Associated with HIV Infection: Identification of Novel Molecular Subtypes. [PDF]
Labiad Y +6 more
europepmc +1 more source
Merkel cell carcinoma: an updated guide for pathologists
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley +1 more source
Diffuse large B-cell lymphoma involving the vagina and a pre-existing uterine leiomyoma. [PDF]
Yagi F +7 more
europepmc +1 more source
Poorly differentiated lung adenocarcinomas with concurrent anaplastic lymphoma kinase (ALK) and CD30 expression closely mimic ALK‐positive anaplastic large‐cell lymphoma, creating a significant diagnostic pitfall. Accurate classification requires comprehensive integration of clinical, radiologic, morphologic, immunophenotypic and molecular findings ...
Jietian Jin +6 more
wiley +1 more source
Musculoskeletal Manifestations of T-Cell Lymphomas: Clinical Presentation, Imaging Features, Pathobiology, and Orthopedic Considerations-A Narrative Review. [PDF]
Alshaygy I +7 more
europepmc +1 more source
Cutaneous involvement by myeloid leukaemias: challenging cases with important implications
Myeloid leukaemias and precursors involving the skin are often challenging to diagnose with varied and overlapping clinical and histopathologic features. Nonetheless, they are critical for pathologists to recognize and accurately classify. This review discusses the clinical, histopathological and genetic features of myelodysplasia cutis (A) and ...
Alexandra C. Hristov
wiley +1 more source
Elevated Expression of Caveolin-1 Reflects a Poor Prognosis in Patients With Primary Central Nervous System Lymphomas. [PDF]
Sugita Y +6 more
europepmc +1 more source

