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Cutaneous T-cell Lymphoma [PDF]

Clinics in Laboratory Medicine, 2017
Cutaneous T-cell lymphomas comprise a heterogeneous group of diseases characterized by monoclonal proliferations of T lymphocytes primarily involving skin, modified skin appendages, and some mucosal sites. This article addresses the basic clinical, histologic, and immunohistochemical characteristics of this group of diseases, with additional attention ...
Sasha Stephen, Ellen J. Kim, Camille E. Introcaso, Stephen K. Richardson, Alain H. Rook   +4 more
semanticscholar   +4 more sources

Cutaneous T-Cell Lymphoma and Microbiota: Etiopathogenesis and Potential New Therapeutic Targets [PDF]

Dermatology Research and Practice
Objective. To review the scientific literature related to human microbiota and cutaneous T-cell lymphoma. Methodology. An exploratory and systematic review of the articles retrieved from the bibliographic databases MEDLINE (PubMed), Embase, The Cochrane ...
Daniel Rodríguez Baeza, Lía Bejarano Antonio, Marta González de Arriba, José Antonio Picó-Monllor, Javier Cañueto, Vicente Navarro-Lopez   +5 more
doaj   +2 more sources

HLA-DR Helps to Differentiate Erythrodermic Cutaneous T-cell Lymphoma from Erythrodermic Inflammatory Dermatoses in Flow Cytometry

Acta Dermato-Venereologica, 2023
Differential diagnosis of erythroderma is challenging in dermatology, especially in differentiating erythrodermic cutaneous T-cell lymphoma from erythrodermic inflammatory dermatoses.
Jingru Sun, Ran You, Beini Lyu, Xueying Li, Yumei Gao, Yujie Wen, Chenxue Qu, Yang Wang   +7 more
doaj   +1 more source

High Expression of IKZF2 in Malignant T Cells Promotes Disease Progression in Cutaneous T Cell Lymphoma

Acta Dermato-Venereologica, 2021
Cutaneous T cell lymphoma is a generally indolent disease derived from skin-homing mature T cells. However, in advanced stages, cutaneous T cell lymphoma may manifest aggressive clinical behaviour and lead to a poor prognosis.
Bufang Xu, Fengjie Liu, Yumei Gao, Jingru Sun, Yingyi Li, Yuchieh Lin, Xiangjun Liu, Yujie Wen, Shengguo Yi, Jingyang Dang, Ping Tu, Yang Wang   +11 more
doaj   +1 more source

Use of Pegylated Interferon Alpha-2a in Cutaneous T-cell Lymphoma: A Retrospective Case Collection

Acta Dermato-Venereologica, 2023
Mycosis fungoides and Sézary syndrome are rare and largely incurable types of cutaneous T-cell lymphoma with limited therapeutic options. In 1984 Bunn et al.
Janika Gosmann, Rudolf Stadler, Koen D. Quint, Ralf Gutzmer, Maarten H. Vermeer   +4 more
doaj   +1 more source

Interleukin-17 Genes Polymorphisms are Significantly Associated with Cutaneous T-cell Lymphoma Susceptibility

Acta Dermato-Venereologica, 2022
Tumour microenvironment has an important effect on the progression of cutaneous T-cell lymphomas. Using PCR with sequence-specific primers, this study analysed single-nucleotide polymorphisms in the interleukin-17 genes of 150 patients with cutaneous T ...
Karol Kołkowski, Jolanta Gleń, Berenika Olszewska, Monika Zabłotna, Roman J. Nowicki, Małgorzata Sokołowska-Wojdyło   +5 more
doaj   +1 more source

CD30-positive cutaneous lymphoma: report of four cases with an emphasis on clinicopathological correlations [PDF]

Anais Brasileiros de Dermatologia, 2017
: The classification of cutaneous lymphomas is multidisciplinary and requires the correlation between clinical, histopathological, immunohistochemical, and molecular diagnostic elements. In this article, we present four different cases of CD30-positive T-
Thiago Jeunon de Sousa Vargas, Samira Barroso Jorge, Yung Bruno de Mello Gonzaga   +2 more
doaj   +2 more sources

Increased Chlormethine-Induced DNA Double-Stranded Breaks in Malignant T Cells from Mycosis Fungoides Skin Lesions

JID Innovations, 2022
Mycosis fungoides (MF) is a type of cutaneous T-cell lymphoma. Chlormethine (CL) is recommended as first-line therapy for MF, with a major purpose to kill tumor cells through DNA alkylation.
Yun-Tsan Chang, Desislava Ignatova, Wolfram Hoetzenecker, Steve Pascolo, Christina Fassnacht, Emmanuella Guenova   +5 more
doaj   +1 more source

Dysregulated Expression of Antimicrobial Peptides in Skin Lesions of Patients with Cutaneous T-cell Lymphoma

Acta Dermato-Venereologica, 2020
Mycosis fungoides and Sézary syndrome belong to the group of primary cutaneous T-cell lymphomas. Because of the inflammatory appearance of the skin lesions, we hypothesized that antimicrobial peptides might be dysregulated in these conditions, similar to
Ulrike Wehkamp, Marion Jost, Kai Wehkamp, Jürgen Harder   +3 more
doaj   +1 more source

Primary cutaneous T-cell lymphoma: experience from the Peruvian National Cancer Institute [PDF]

Anais Brasileiros de Dermatologia, 2017
: Background: Primary cutaneous T-cell lymphomas constitute a heterogeneous and rare group of diseases with regional particularities in Latin America.
Rosana Ruiz, Zaida Morante, Raul Mantilla, Luis Mas, Luis Casanova, Henry L. Gomez   +5 more
doaj   +1 more source