Results 1 to 10 of about 147,528 (279)

Spectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in cutaneous T-cell lymphoma

Scientific Reports, 2021
T-cell non-Hodgkin’s lymphomas develop following transformation of tissue resident T-cells. We performed a meta-analysis of whole exome sequencing data from 403 patients with eight subtypes of T-cell non-Hodgkin’s lymphoma to identify mutational ...
Christine L. Jones, Andrea Degasperi, Vieri Grandi, Tauanne D. Amarante, Genomics England Research Consortium, Tracey J. Mitchell, Serena Nik-Zainal, Sean J. Whittaker   +7 more
doaj   +2 more sources

Cutaneous T-cell Lymphoma. [PDF]

Clinics in Laboratory Medicine, 2017
Cutaneous T-cell lymphomas comprise a heterogeneous group of diseases characterized by monoclonal proliferations of T lymphocytes primarily involving skin, modified skin appendages, and some mucosal sites. This article addresses the basic clinical, histologic, and immunohistochemical characteristics of this group of diseases, with additional attention ...
M. Pulitzer
semanticscholar   +6 more sources

Care and treatment for primary cutaneous lymphoma-associated ulcers: Two case reports [PDF]

SAGE Open Medical Case Reports
Primary cutaneous lymphoma is a heterogeneous group of cutaneous lymphocytic primary tumors belonging to the extranodal category of non-Hodgkin lymphoma.
Min Wei, Jun Wei, Jian Li, Ruyue Li, Jing Liu   +4 more
doaj   +2 more sources

New Therapies and Immunological Findings in Cutaneous T-Cell Lymphoma

Frontiers in Oncology, 2018
Primary cutaneous lymphomas comprise a group of lymphatic malignancies that occur primarily in the skin. They represent the second most common form of extranodal non-Hodgkin’s lymphoma and are characterized by heterogeneous clinical, histological ...
Kazuyasu Fujii
doaj   +2 more sources

HLA-DR Helps to Differentiate Erythrodermic Cutaneous T-cell Lymphoma from Erythrodermic Inflammatory Dermatoses in Flow Cytometry

Acta Dermato-Venereologica, 2023
Differential diagnosis of erythroderma is challenging in dermatology, especially in differentiating erythrodermic cutaneous T-cell lymphoma from erythrodermic inflammatory dermatoses.
Jingru Sun, Ran You, Beini Lyu, Xueying Li, Yumei Gao, Yujie Wen, Chenxue Qu, Yang Wang   +7 more
doaj   +1 more source

Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma

Nature Communications, 2022
Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin lymphoma distinguished by the presence of clonal malignant T cells. The heterogeneity of malignant T cells and the complex tumor microenvironment remain poorly characterized.
Xiangjun Liu, Shanzhao Jin, Simeng Hu, Ruoyan Li, Haihao Pan, Yi Liu, P. Lai, Deshu Xu, Jingru Sun, Ziyang Liu, Yumei Gao, Yifan Zhao, Fengjie Liu, Yu Xiao, Yingyi Li, Yujie Wen, Zhuojing Chen, Bu-Fang Xu, Yuchieh Lin, M. Ran, Qianxi Li, Shuxia Yang, Hang Li, P. Tu, M. Haniffa, S. Teichmann, F. Bai, Yang Wang   +27 more
semanticscholar   +1 more source

Randomized phase 3 ALCANZA study of brentuximab vedotin vs physician’s choice in cutaneous T-cell lymphoma: final data

Blood Advances, 2021
Key Points Final ALCANZA data confirm more durable responses and longer PFS with brentuximab vedotin vs control in CD30+ cutaneous T-cell lymphoma. Brentuximab vedotin extended the time to next treatment vs physician's choice, suggesting that durable ...
S. Horwitz, J. Scarisbrick, R. Dummer, S. Whittaker, M. Duvic, Youn H. Kim, P. Quaglino, P. Zinzani, O. Bechter, H. Eradat, L. Pinter-Brown, O. Akilov, L. Geskin, J. Sanches, P. Ortiz-Romero, M. Weichenthal, D. Fisher, J. Walewski, J. Trotman, K. Taylor, S. Dalle, R. Stadler, J. Lisano, V. Bunn, M. Little, H. Prince   +25 more
semanticscholar   +1 more source

Immunomodulation in Cutaneous T Cell Lymphoma [PDF]

Frontiers in Oncology, 2019
Martina Ferranti, Giulia Tadiotto Cicogna, Irene Russo, Mauro Alaibac   +3 more
doaj   +5 more sources

High Expression of IKZF2 in Malignant T Cells Promotes Disease Progression in Cutaneous T Cell Lymphoma

Acta Dermato-Venereologica, 2021
Cutaneous T cell lymphoma is a generally indolent disease derived from skin-homing mature T cells. However, in advanced stages, cutaneous T cell lymphoma may manifest aggressive clinical behaviour and lead to a poor prognosis.
Bufang Xu, Fengjie Liu, Yumei Gao, Jingru Sun, Yingyi Li, Yuchieh Lin, Xiangjun Liu, Yujie Wen, Shengguo Yi, Jingyang Dang, Ping Tu, Yang Wang   +11 more
doaj   +1 more source

Use of Pegylated Interferon Alpha-2a in Cutaneous T-cell Lymphoma: A Retrospective Case Collection

Acta Dermato-Venereologica, 2023
Mycosis fungoides and Sézary syndrome are rare and largely incurable types of cutaneous T-cell lymphoma with limited therapeutic options. In 1984 Bunn et al.
Janika Gosmann, Rudolf Stadler, Koen D. Quint, Ralf Gutzmer, Maarten H. Vermeer   +4 more
doaj   +1 more source