Results 91 to 100 of about 609,040 (315)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Composite Lymphoma: EBV-positive Classic Hodgkin Lymphoma and Peripheral T-cell Lymphoma A Case Report [PDF]

, 2009
Composite lymphomas are rare and defined as hematopoietic neoplasms with more than I malignant lymphomatous clone showing different phenotypic features.
Berg, Anke Van Den, Weiss, Lawrence M., Bacchi, Carlos E., Van Den Berg, Anke; id_orcid, Gualco, Gabriela, Van Den Berg, Anke, Chioato, Lucimara   +6 more
core   +1 more source

Chimeric antigen receptor (CAR) -T cell therapy treatment Richter's transformation

Frontiers in Oncology
Background/purposeDespite advances in chronic lymphocytic leukemia treatment, effective therapies for cases with Richter’s transformation (RT) are urgently needed. This study aimed to investigate the use of chimeric antigen receptor (CAR)-T cell infusion
Shaomei Feng, Peihao Zheng, Haidi Liu, Meiling Sun, Yuelu Guo, Lixia Ma, Rui Liu, Zhonghua Fu, Fan Yang, Xiaoyan Ke, Kai Hu   +10 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Specific metaphase and interphase detection of the breakpoint region in 8q24 of burkitt lymphoma cells by triple-color fluorescence in situ hybridization [PDF]

, 1992
Triple fluorescence in situ hybridization with a plasmid DNA library from sorted human chromosomes 8 in combination with bacteriophage clones flanking the breakpoint in 8q24 of the Burkitt lymphoma cell line Jl was used for the specific delineation of ...
Thomas Ried, Peter Groitl, Wiegant, Joop, Lipp, Martin, Joop Wiegant, Ried, Thomas, Martin Lipp, Groitl, P., Cremer, Thomas, Wiegant, J., Christoph Lengauer, Raap, A.K., van der Ploeg, M., Cremer, T., Mels Van Der Ploeg, Lipp, M., Ried, T., Raap, Anton K., Van Der Ploeg, Mels, Groitl, Peter, Lengauer, C., Anton K. Raap, Lengauer, Christoph, Thomas Cremer   +23 more
core   +1 more source

Spontaneous regression of mantle cell lymphoma: a report of four cases

Cancer Communications, 2018
Background Spontaneous regression has been reported in some indolent forms of lymphoma. Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm and has a poor prognosis.
Haige Ye, Aakash Desai, Tiejun Gong, Dongfeng Zeng, Krystle Nomie, Wendy Chen, Wei Wang, Jorge Romaguera, Michael L. Wang   +8 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The Lymphoma Information Network [PDF]

The Lymphoma Information Network website strives to "put a bit of humanity and understanding to this disease, to gather lymphoma information and resources in one place, and to present information in an easy to understand and logical format." ...

core  

Hodgkin lymphoma treatment with ABVD in the US and the EU: neutropenia occurrence and impaired chemotherapy delivery [PDF]

, 2010
BACKGROUND: In newly diagnosed patients with Hodgkin lymphoma (HL) the effect of doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD)-related neutropenia on chemotherapy delivery is poorly documented.
Lyman, Gary H., Lyman, Gary H, Szucs Thomas D, Culakova Eva, Szucs, Thomas D., Thomas D Szucs, Pettengell, Ruth, Szucs, Thomas D, Eva Culakova, Lyman, GH, Culakova, Eva, Ruth Pettengell, Matthias Schwenkglenks, Pettengell, R, Schwenkglenks, Matthias, Szucs, TD, Gary H Lyman, Pettengell Ruth, Culakova, E, Schwenkglenks Matthias, Lyman Gary H, Lyman, G H, Szucs, T D, Schwenkglenks, M   +23 more
core   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source