Results 131 to 140 of about 1,110,252 (341)

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Strategies for increasing accrual in cancer clinical trials: What is the evidence?

Cancer Medicine
Introduction Despite the importance of clinical trial participation among cancer patients, few participate—and even fewer patients from ethnic and racial minoritized groups.
Margo Michaels, Elisa S. Weiss, Maria Sae‐Hau, Dora Illei, Bethany Lilly, Leah Szumita, Brian Connell, Marialanna Lee, Eric Cooks, Melissa McPheeters   +9 more
doaj   +1 more source

Multicentric B-cell lymphoma in a pygmy goat [PDF]

, 2016
A six-year-old, male pygmy goat was referred with a sudden onset of peripheral lymphadenopathy, which initially started as enlarged inguinal lymph nodes. Clinical examination showed swollen retropharyngeal, prescapular and inguinal lymph nodes. Serologic
Chiers, Koen, Deprez, Piet, Kolkman, Iris, Pardon, Bart, Ribbens, Stefaan, Van Aert, Marcel, Versnaeyen, Han   +6 more
core  

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Comparison of CHOP ‐19 and CHOP ‐25 for treatment of peripheral nodal B‐cell lymphoma in dogs: A European multicenter retrospective cohort study [PDF]

Claire Hawkes, Joanna S. Morris, Špela Bavčar, Craig Wilkie, Surajit Ray, Charlotte Auquier, Sarah Benjamin, J.F. Martí-Massó, Sébastien Bottin, Owen Davies, Isabelle Desmas‐Bazelle, Anat Einhorn, Celia Figueroa‐González, Katerina Holenova, Elisavet Kritsotalaki, Kerry Peak, Katherine Smallwood, Elisabetta Treggiari, Paola Valenti, M. Virgen, Quentin Fournier   +20 more
openalex   +1 more source

Figures S1-S7 from An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas

, 2023
Leandro Venturutti, Martín A. Rivas, Benedikt W. Pelzer, Ruth Flümann, Julia Hansen, Ioannis Karagiannidis, Min Xia, Dylan McNally, Yusuke Isshiki, Andrew Lytle, Matt Teater, Christopher R. Chin, Cem Meydan, Gero Knittel, Edd Ricker, Christopher E. Mason, Xiaofei Ye, Qiang Pan‐Hammarström, Christian Steidl, David W. Scott, Hans Christian Reinhardt, Alessandra B. Pernis, Wendy Béguelin, Ari Melnick   +23 more
openalex   +2 more sources

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Supplementary Figure S5 from Targeting CD20⁺ Aggressive B-cell Non–Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells <i>In Vitro</i> and in NSG Mice

, 2023
Yaya Chu, Jessica Hochberg, Ashlin Yahr, Janet Ayello, Carmella van de Ven, Matthew Barth, Myron S. Czuczman, Mitchell S. Cairo   +7 more
openalex   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

PB2086: CHRONIC LYMPHOPROLIFERATIVE DISORDER OF NK CELLS WITH LIVER INFILTRATION

HemaSphere, 2022
V. Otasevic, D. Antic, V. Vukovic, V. Djurasinovic, K. Tomic, B. Mihaljevic   +5 more
doaj   +1 more source