Results 61 to 70 of about 67,043 (290)

Lymphopenia in sepsis—an acquired immunodeficiency?

Immunology & Cell Biology, 2022
AbstractSepsis is a global health priority, yet effective host‐directed targeted therapies have not been identified outside of the setting of coronavirus disease 2019 (COVID‐19). Lymphopenia occurs in up to ~52% of patients with sepsis and is associated with a higher mortality at both 30 and 100 days. In COVID‐19, the presence of lymphopenia correlates
Simon, Finfer, Balasubramanian, Venkatesh, Richard S, Hotchkiss, Sarah C, Sasson   +3 more
openaire   +2 more sources

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

Neonatal screening for absolute lymphopenia

, 2014
Background: Blood counts with manual differentials could diagnose nearly all cases of severe combined immune deficiency (SCID) at birth. Objective: The aim of this study was to outline the prevalence of neonatal lymphopenia among newborns of Obstetrics ...
El-Sayed, SS, El-Sayed Afifi, HM, Yahia, ASh   +2 more
core   +1 more source

Multivariate Analysis of Hematological Stress Biomarkers and Welfare Domains in Organic and Intensive Pig Farming in Italy: A Pilot Study

Animal Research and One Health, EarlyView.
Intensive or organic farming systems may expose pigs to management or environmental challenges. Our preliminary results concluded that organic farming might enhance adaptive immune function, showing that improvements in welfare can translate into measurable immunological benefits, based on the correlation between welfare assessment and physiological ...
Dorotea Ippolito, Talal Hassan, Antonio Marco Maisano, Stefania Bergagna, Cecilia Guasco, Barbara Miniscalco, Martina Tarantola, Elena Colombino, Claudio Caruso, Ahsan Muhammad, Silvia Mioletti, Laura Tomassone, Massimiliano Tursi, Cristina Vercelli, Giovanni Loris Alborali, Maria Teresa Capucchio   +15 more
wiley   +1 more source

Systematic review and pooled analysis of the impact of treatment-induced lymphopenia on survival of glioblastoma patients

Radiation Oncology
Purpose/objective(s) Treatment related lymphopenia is a known toxicity for glioblastoma (GBM) patients and several single-institution studies have linked lymphopenia with poor survival outcomes.
Ali M. Saeed, Søren M. Bentzen, Haroon Ahmad, Lily Pham, Graeme F. Woodworth, Mark V. Mishra   +5 more
doaj   +1 more source

Immune Complexes Shape the Pathogenicity of Autoantibodies in Systemic Autoimmune Diseases: Insights From an FcγRIIIA‐Reporter Assay

Arthritis &Rheumatology, EarlyView.
Objective Immune complexes (ICs), formed by autoantigen and autoantibody, play a pathogenic role in systemic autoimmune diseases through stimulation of Fcγ receptors (FcγR). However, studies investigating bioactivity of circulating ICs across various diseases remain limited.
Koji Suzuki, Masaru Takeshita, Yuki Imai, Hiroyuki Fukui, Kazunori Furuhashi, Kotaro Matsumoto, Jun Kikuchi, Keiko Yoshimoto, Yuko Kaneko   +8 more
wiley   +1 more source

A Prospective Cohort Study of the Clinical Predictors of Bacteremia in Under-Five Children With Acute Undifferentiated Fever Attending a Secondary Health Facility in Northwestern Nigeria

Frontiers in Pediatrics, 2022
BackgroundChildren with acute febrile illness with no localizing signs often receive antibiotics empirically in most resource-poor settings. However, little is known about the burden of bacteremia in this category of patients, and an appraisal is thus ...
Taofik Oluwaseun Ogunkunle, Timothy Olanrewaju Adedoyin, Samuel Kolade Ernest, Fatimah Hassan-Hanga, Abdulazeez Imam, Rasaq Olaosebikan, Stephen K. Obaro   +6 more
doaj   +1 more source

Impact of lymphopenia on efficacy of nivolumab in head and neck cancer patients

, 2023
International audienceIntroductionLymphopenia has been correlated with poorer survival in patients with metastatic cancers treated with anti-PD-1 immunotherapy. Treatments such as chemotherapy, surgery or radiotherapy can induce lymphopenia.
Césaire, Mathieu, Johnson, Alisson, Clatot, Florian, Thariat, Juliette, Rambeau, Audrey, Heutte, Natacha   +5 more
core   +1 more source

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

Arthritis &Rheumatology, Accepted Article.
Background Type I interferonopathies are heterogeneous diseases driven by dysregulated IFN‐I signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. Objective To characterize the clinical, immunological, genetic, molecular profiles of patients with suspected enhanced IFN‐I signaling, and assess ...
Ismail Yaz, Seza Ozen, Hacer N. Bildik, Canberk Ipsir, Dilara Unal, Saliha Esenboga, Begum Cicek, Mehmet E. Seker, Fatima Aerts‐Kaya, Seher Sener, Mehmet O. Erkan, Hanife Avci, Deniz Cagdas, Ilhan Tezcan   +13 more
wiley   +1 more source

Effect of Lymphopenia on Tumor Response and Clinical Outcomes Following Chemoradiotherapy in Stage III Non-Small Cell Lung Cancer

, 2023
Jared Deck,1 Marissa Hartley,1 Mohammad Akhter,1 Dongliang Wang,2 Jeffrey A Bogart,1 Michael D Mix1 1Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, NY, USA; 2Department of Public Health and Preventive Medicine, SUNY Upstate ...
Akhter M, Deck J, Bogart JA, Wang D, Mix MD, Hartley M   +5 more
core