Results 71 to 80 of about 67,043 (290)

Lymphopenia during radiotherapy in patients with oropharyngeal cancer

, 2020
PURPOSE/OBJECTIVE: Radiation-induced lymphopenia has been associated with poor survival outcomes in certain solid tumors such as esophageal, lung, cervical and pancreatic cancers.
Pollard, C, Fuller, CD, Skinner, HD, Elhalawani, H, Phan, J, Garden, AS, Mohamed, ASR, Rosenthal, DI, Ng, SP, Bahig, H, Johnson, FM, Gunn, GB, Berends, J, Frank, SJ, Jethanandani, A, Sturgis, EM, Elgohari, B   +16 more
core   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Dimethyl fumarate-associated lymphopenia: Risk factors and clinical significance

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2015
Background Dimethyl fumarate (DMF), a disease-modifying therapy for multiple sclerosis (MS), causes lymphopenia in a fraction of patients. The clinical significance of this is unknown.
Erin E Longbrake, Robert T Naismith, Becky J Parks, Gregory F Wu, Anne H Cross   +4 more
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Details of opportunistic infections during lymphopenia.

, 2016
Details of opportunistic infections during lymphopenia.
Marius Vögelin (2805241), Michael Fried (139963), Jonas Zeitz (389786), Pascal Frei (139961), Michael Scharl (139957), Gerhard Rogler (139954), Sylvie Scharl (2805235), Stephan R. Vavricka (139972), Michael C. Sulz (2805238), Luc Biedermann (139959)   +9 more
core   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Lymphopenia in atopic dermatitis patients treated with oral immunosuppressive drugs

, 2018
Introduction: Oral immunosuppressive drugs are commonly used in the treatment of atopic dermatitis (AD). In patients with autoimmune- and rheumatic diseases, these drugs have been associated with lymphopenia.
Daphne S. Bakker, Bruijnzeel-Koomen, Carla A.F.M., de Bruin-Weller, Marjolein S., Helen L. Leavis, van der Schaft, Jorien, Floor M. Garritsen, Garritsen, Floor M., Marcel P.H. van den Broek, Jorien van der Schaft, van den Broek, Marcel P.H., Carla A.F.M. Bruijnzeel-Koomen, Leavis, Helen L., Marjolein S. de Bruin-Weller, Bakker, Daphne S.   +13 more
core   +1 more source

Assessing Clinical Severity and Prognosis in Adolescents With Anorexia Nervosa and Atypical Anorexia Nervosa Using the Albumin‐Globulin Ratio

European Eating Disorders Review, EarlyView.
ABSTRACT Objective The albumin‐globulin ratio (AGR) is a biochemical marker reflecting nutritional and inflammatory status, with significant prognostic value in chronic conditions. This study examined its association with clinical/biochemical markers in adolescents with anorexia nervosa (AN) and atypical AN (AAN).
Eylem Şerife Kalkan, Ayşe Bilge Baklaci, Yelda Kiliç, Sinem Akgül, Nilgün Özgül, Melis Pehlivanturk Kizilkan   +5 more
wiley   +1 more source

Cytomegalovirus haemorrhagic colitis complicating COVID‐19 in an immunocompetent critically ill patient: A case report

Clinical Case Reports, 2021
Suspicion threshold for opportunistic coinfections should be lowered in severe COVID‐19. Serum CMV polymerase chain reaction and colonoscopy should be discussed in presence of persistent digestive disturbances.
Sophie Leemans, Evelyne Maillart, Héloïse Van Noten, Lucas Oliveira Dos Santos, Laura Maria Leahu, Prochore Kamgang, Andrea Gallerani, Philippe Clevenbergh   +7 more
doaj   +1 more source