Results 41 to 50 of about 97,922 (330)

Recommended Best Practices for Lyophilization Validation—2021 Part I: Process Design and Modeling

AAPS PharmSciTech, 2021
This work describes lyophilization process validation and consists of two parts. Part I focuses on the process design and is described in the current paper, while part II is devoted to process qualification and continued process verification.
F. Jameel, Alina A. Alexeenko, Akhilesh Bhambhani, Gregory A. Sacha, Tong Zhu, Serguei Tchessalov, L. Kumar, Puneet Sharma, Ehab Moussa, Lavanya K. Iyer, Rui Fang, J. Srinivasan, Ted Tharp, Joseph Azzarella, Petr Kazarin, M. Jalal   +15 more
semanticscholar   +1 more source

Effect of pretreatment, lyophilization parameters and different cryoprotectants on the efficiency of probiotic freeze-drying immobilization [PDF]

Hemijska Industrija
Lyophilization is an excellent process to increase the shelf life of food products or preserve probiotics. Living cells prefer mild conditions, and any deviation (vacuum, high or low temperatures) leads to cell damage.
Krunić Tanja Ž., Osmokrović Andrea M.
doaj   +1 more source

Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses [PDF]

, 2017
In the pharmaceutical industry, traditional freeze-drying of unit doses is a batch-wise process associated with many disadvantages. To overcome these disadvantages and to guarantee a uniform product quality and high process efficiency, a continuous ...
Corver, Jos, De Beer, Thomas, De Meyer, Laurens, Lammens, Joris, Mortier, Séverine, Nopens, Ingmar, Van Bockstal, Pieter-Jan, Vanbillemont, Brecht, Vervaet, Chris   +8 more
core   +1 more source

Recommended Best Practices for Lyophilization Validation 2021 Part II: Process Qualification and Continued Process Verification

AAPS PharmSciTech, 2021
This work describes the lyophilization process validation and consists of two parts. Part one (Part I: Process Design and Modeling) focuses on the process design and is described in the previous paper, while the current paper is devoted to process ...
F. Jameel, Alina A. Alexeenko, Akhilesh Bhambhani, Gregory A. Sacha, Tong Zhu, Serguei Tchessalov, Puneet Sharma, Ehab Moussa, Lavanya K. Iyer, S. Luthra, J. Srinivasan, Ted Tharp, Joseph Azzarella, Petr Kazarin, M. Jalal   +14 more
semanticscholar   +1 more source

Cyclophosphamide removal from water by nanofiltration and reverse osmosis membrane [PDF]

, 2009
The rejection of cyclophosphamide (CP) by nanofiltration (NF) and reverse osmosis (RO) membranes from ultrapure (Milli-Q) water and membrane bioreactor (MBR) effluent was investigated.
Albasi, Claire, Causserand, Christel, Dorandeu, Christophe, Faucet-Marquis, Virginie, Marion, Bénédicte, Pfohl-Leszkowicz, Annie, Wang, Li   +6 more
core   +2 more sources

Selection of Cryoprotectant in Lyophilization of Progesterone-Loaded Stearic Acid Solid Lipid Nanoparticles

Pharmaceutics, 2020
Cryoprotectants are often required in lyophilization to reduce or eliminate agglomeration of solute or suspended materials. The aim of this study was to select a cryoprotecting agent and optimize its concentration in a solid lipid nanoparticle ...
Timothy M Amis, Jwala Renukuntla, Pradeep Kumar Bolla, B. Clark   +3 more
semanticscholar   +1 more source

Conservation of Microorganisms of Biotechnological Interest

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Food Science and Technology
Thirty strains of microorganisms from the National Collection of Nonpathogenic Microorganisms (NCNM) were used as study objects (actinobacteria, bacteria, and micromycetes).
Tamara SÎRBU, Cristina MOLDOVAN, Valerian SLANINA, Maxim BÎRSA   +3 more
doaj   +1 more source

A strategy to promote the convenient storage and direct use of polyhydroxybutyrate-degrading Bacillus sp. JY14 by lyophilization with protective reagents

Microbial Cell Factories, 2023
Background Bioplastics are attracting considerable attention, owing to the increase in non-degradable waste. Using microorganisms to degrade bioplastics is a promising strategy for reducing non-degradable plastic waste.
Su Hyun Kim, Nara Shin, Suk Jin Oh, Jeong Hyeon Hwang, Hyun Jin Kim, Shashi Kant Bhatia, Jeonghee Yun, Jae-Seok Kim, Yung-Hun Yang   +8 more
doaj   +1 more source

Effectiveness of Lyoprotectants in Protein Stabilization During Lyophilization

Pharmaceutics
Background: Proteins are commonly used in the healthcare industry to treat various health conditions, and most proteins are sensitive to physical and chemical changes. Lyophilization, also known as freeze-drying, involves sublimating water in the form of
Vinoothini Karunnanithy, Nur Hazirah Binti Abdul Rahman, N. Abdullah, M. B. Fauzi, Y. Lokanathan, Angela Ng Min Hwei, Manira Maarof   +6 more
semanticscholar   +1 more source

Biopolymer-based structuring of liquid oil into soft solids and oleogels using water-continuous emulsions as templates [PDF]

, 2015
Physical trapping of a hydrophobic liquid oil in a matrix of water-soluble biopolymers was achieved using a facile two-step process by first formulating a surfactant-free oil-in-water emulsion stabilized by biopolymers (a protein and a polysaccharide ...
Adelmann H., Aiache J. M., Amar-Yuli I., Ans Lesaffer, Ashok R. Patel, Bastiat G., Bastiat G., Benny Lewille, Bot A., Cho Y.-H., Cho Y.-H., Derkach S. R., Doublier J. L., Foudazi R., Fukasawa J.-I., Gallardo V., García-Zapateiro L. A., Goodwin J. W., Grigoriev D. O., Grysko M., Gu Y. S., Gu Y. S., Hanazawa T., Hanazawa T., Hasenhuettl G. L., Hughes N. E., Jost R., Kjøniksen A.-L., Klinkesorn U., Koen Dewettinck, Li Z., Lii C. y., Mandal S. K., Marangoni A., Marangoni A., McClements D. J., Mezzenga R., Mezzenga R., Mitchell J. R., Moschakis T., Nick Cludts, Núñez N., Núñez N., Patel A. R., Patel A. R., Pons R., Pravin S. Rajarethinem, Princen H. M., Rodríguez Patino J. M., Rogers M. A., Romoscanu A. I., Sanchez R., Svobodova H., Sánchez R., Sánchez R., Sánchez R., Vílchez A., Vílchez S., Wilde P., Winnok H. De Vos   +59 more
core   +3 more sources