Results 51 to 60 of about 97,922 (330)

Lyoprotectant Constituents Suited for Lyophilization and Reconstitution of Stem-Cell-Derived Extracellular Vesicles

Biomaterials Research
Stem-cell-derived extracellular vesicles (EVs) are emerging as an alternative approach to stem cell therapy. Successful lyophilization of EVs could enable convenient storage and distribution of EV medicinal products at room temperature for long periods ...
Wu Young Kang, Eun Kyoung Shin, Eun Hee Kim, Min‐Ho Kang, Chi Young Bang, Oh Young Bang, Jae Min Cha   +6 more
semanticscholar   +1 more source

Development of Lyophilized Gemini Surfactant-Based Gene Delivery Systems: Influence of Lyophilization on the Structure, Activity and Stability of the Lipoplexes

Journal of Pharmacy & Pharmaceutical Sciences, 2012
Purpose. Cationic gemini surfactants have been studied as non-viral vectors for gene therapy. Clinical applications of cationic lipid/DNA lipoplexes are restricted by their instability in aqueous formulations.
Waleed Mohammed-Saeid, Deborah Michel, Anas El-Aneed, Ronald E Verrall, Nicholas H Low, Ildiko Badea   +5 more
doaj   +1 more source

Effect of freezing temperature on rate of survival of lactococcus cultures during lyophilization

Пищевые системы
The important component in the activities of the collection of starter microorganisms is the preservation of the pool of the strains valuable for industrial production.
I. V. Kucherenko, E. V. Kuraeva, E. S. Masegnaya   +2 more
doaj   +1 more source

The impact of freeze-drying infant fecal samples on measures of their bacterial community profiles and milk-derived oligosaccharide content. [PDF]

, 2016
Infant fecal samples are commonly studied to investigate the impacts of breastfeeding on the development of the microbiota and subsequent health effects.
Davis, Jasmine CC, German, J Bruce, Lebrilla, Carlito B, Lewis, Zachery T, Mills, David A, Smilowitz, Jennifer T   +5 more
core   +2 more sources

OPTIMIZATION OF BACTERIAL LYOPHILIZATION PROCESS: INFLUENCE OF CULTIVATION AND LYOPHILIZATION PARAMETERS ON PROBIOTIC SURVIVAL RATE

Siberian Journal of Life Sciences and Agriculture
Background. The preservation of bacterial cultures plays an important role in scientific research and industrial production, both food and medical.
Mariia S. Ashikhmina, Vladislav S. Filozop, Mikhail O. Volodarskiy, Sviatlana A. Ulasevich, Ekaterina V. Skorb   +4 more
doaj   +1 more source

Development of a DNA-Liposome Complex for Gene Delivery Applications [PDF]

, 2017
The association structures formed by cationic liposomes and DNA(Deoxyribonucleic acid)-liposome have been effectively utilized as gene carriers in transfection assays.
Ambrose, J. J., Boughdachi, A., Khoshkenar, Payam, Kiaie, N., Kupgan, G., Moghadam, F., Ramsey, J. D., Rasoulianboroujeni, Morteza, Tayebi, Lobat, Vashaee, Daryoosh   +9 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Site-specific incorporation of phosphotyrosine using an expanded genetic code. [PDF]

, 2017
Access to phosphoproteins with stoichiometric and site-specific phosphorylation status is key to understanding the role of protein phosphorylation.
Allison Wong, Bing Yang, C Fan, C Hoppmann, Christian Hoppmann, CS Tan, DB Johnson, DT Rogerson, H-G Chao, HS Park, J Xie, JJ Ottesen, JK Takimoto, JP Oza, Kevan M Shokat, L Wang, Lei Wang, M Jbara, MK Tarrant, NL Pirman, P Blume-Jensen, PV Hornbeck, R Serwa, R Yau, RA Chong, S George, SG Julien, Shuwei Li, SJ Humphrey, SW Santoro, T Hunter, T Wauer, Tony Hunter, VK Lacey, WA Lim, Z Chen, Z Xiang   +36 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Freeze-Drying of a Capsid Virus-like Particle-Based Platform Allows Stable Storage of Vaccines at Ambient Temperature

Pharmaceutics, 2022
The requirement of an undisrupted cold chain during vaccine distribution is a major economic and logistical challenge limiting global vaccine access.
Kara-Lee Aves, Christoph M. Janitzek, Cyrielle E. Fougeroux, Thor G. Theander, Adam F. Sander   +4 more
doaj   +1 more source