Results 161 to 170 of about 4,689 (214)
Oxidation of lysergic acid diethylamide (LSD) by peroxidases: a new metabolic pathway
Lysergic acid diethylamide (LSD) is a potent hallucinogen that is primarily metabolized to 2-oxo-3-hydroxy-LSD (O-H-LSD) and N-desmethyl-LSD (nor-LSD) by cytochrome P450 complex liver enzymes.
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Progression of Effects of Lysergic Acid Diethylamide [LSD]
Archives of Neurology And Psychiatry, 1956Introduction Since the Swiss chemist Hoffman, on April 16, 1943, accidentally discovered the mental effects of lysergic acid diethylamide (LSD-25), a great many experiments with the drug have been reported in various journals. Observations show most agreement in the area of physical subjective symptoms and unreality and least agreement in changes of ...
S, SALVATORE, R W, HYDE
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Lysergic Acid Diethylamide (LSD): No Teratogenicity in Rats
Science, 1968Lysergic acid diethylamide (LSD) in doses of 1.5 to 300 micrograms was given to 55 pregnant rats during periods of organogenesis and on the 4th or 5th day of pregnancy to 34 rats. Examination of the resultant 887 young for congenital defects showed no greater frequency than in controls. These experiments failed to prove that LSD is teratogenic in rats.
J, Warkany, E, Takacs
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Genetic toxicology of lysergic acid diethylamide (LSD-25)
Mutation Research/Reviews in Genetic Toxicology, 1977The acute and the chronic psychotomimetic potentials of the hallucinogen lysergic acid diethylamide (LSD-25) have been recognized for almost 40 years. That additional types of the biological effects should have come under scrutiny was directly attributable to widespread use and abuse of this drug on a world-wide basis.
M M, Cohen, Y, Shiloh
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Lysergic acid diethylamide (LSD-25) and chromosome breaks
Human Genetics, 1968Chromosomes were studied in 32 non-LSD-using controls (Group I), nine psychiatric patients treated with LSD (Group IIa), and a young married couple, both of whom had taken LSD, and their child (Group IIb). The incidence of chromosomal breaks in Groups IIa and IIb was significantly higher than that of Control Group I.
G, Abbo, A, Norris, H, Zellweger
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Mescaline and lysergic acid diethylamide (LSD) as discriminative stimuli
Psychopharmacologia, 1971The observation that a particular drug state may acquire the properties of a discriminative stimulus is explicable on the basis of drug-induced interoceptive cues. The present investigation sought to determine (a) whether the hallucinogens mescaline and LSD could serve as discriminative stimuli when either drug is paired with saline and (b) whether ...
I D, Hirschhorn, J C, Winter
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Complications Associated with Lysergic Acid Diethylamide (LSD-25)
JAMA: The Journal of the American Medical Association, 1962TWO DECADES AGO Hofmann ' accidentally discovered the hallucinogenic activity of d-lysergic acid diethylamide (LSD-25). Its ability to induce a "model psychosis" makes it an excellent laboratory device for the study of psychotic-like phenomena. LSD-25 has also been employed as an adjunct to psychotherapy because recall of repressed memories is enhanced
S, COHEN, K S, DITMAN
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Lysergic Acid Diethylamide (LSD-25) and Ego Functions
Archives of General Psychiatry, 1963In 1947, Stoll32in Switzerland reported on the effects of D-lysergic acid diethylamide (LSD-25), an ergot derivative which can produce profound psychological effects in humans when it is given in minute doses. Since that time, a large volume of literature has grown up around this substance. LSD has been put to many uses.
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Lysergic Acid Diethylamide (LSD-25)
A.M.A. Archives of Neurology & Psychiatry, 1958Although it is known that lysergic acid diethylamide (LSD-25) enters the brain, the mechanism by which LSD-25 acts to produce the psychotic patterns in man is unknown. Experiments which are designed to investigate the brain process in the intact animal might lead to a concept that could be developed to study the chemical process originating or ...
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The Pharmacology of Mescaline and D-Lysergic Acid Diethylamide (LSD)
New England Journal of Medicine, 1958DURING the last few years a great revival of interest has occurred in the search for a biochemical basis for schizophrenia and the other types of psychosis. There are several reasons for this.
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