Results 51 to 60 of about 37,615 (246)

Duplicate abalone egg coat proteins bind sperm lysin similarly, but evolve oppositely, consistent with molecular mimicry at fertilization. [PDF]

PLoS Genetics, 2013
Sperm and egg proteins constitute a remarkable paradigm in evolutionary biology: despite their fundamental role in mediating fertilization (suggesting stasis), some of these molecules are among the most rapidly evolving ones known, and their divergence ...
Jan E Aagaard, Stevan A Springer, Scott D Soelberg, Willie J Swanson   +3 more
doaj   +1 more source

Complete Genome Sequences of Mycobacterium smegmatis Phages Chewbacca, Reptar3000, and Riparian, Isolated in Las Vegas, Nevada [PDF]

, 2019
Here, we present the complete genome sequences of Mycobacterium smegmatis phages Chewbacca, Reptar3000, and Riparian, isolated from soil in Las Vegas, NV.
Ayala-Pineda, Kevin, Barroga, Nicolas, Cadiz, Vanessa, Cassin, Erin, Cisneros, Ramiro, Fersini, Joseph, Ines, Juvie, Jeanite, Tiffany, Juste, Jonathan, Leyva, Gabriel, Macalinao, Dyanne, Muscelli, Spencer, Nhan, Sophia, Regner, Kurt, Reyes, Gustavo S., Rhoden, Heather, Salisbury, Alicia, Strong, Christy, Tan, Rodney, Torres, Erika, Tran, Krystal, Tsourkas, Philippos K., Uriarte-Valle, Georgette, Wallace, Christopher, Wong, Simon   +24 more
core   +2 more sources

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

GbWAKL20 Phosphorylates GbNFYB8 to Modulate Verticillium Wilt Resistance in Cotton

Advanced Science, EarlyView.
Wall‐associated receptor‐like kinases (WAKLs) play pivotal roles in extracellular–intracellular signal transduction. Upon sensing Verticillium dahliae infestation at the plasma membrane, GbWAKL20 accumulates and transmits signals to the nucleus via endoplasmic reticulum‐mediated Golgi vesicle transport.
Guilin Wang, Qingxin Si, Zhiguo Chen, Zhe Yu, Zhan Guo, Lu Wang, Weixi Li, Wangzhen Guo   +7 more
wiley   +1 more source

New insight into the biological activity of Salmo salar NK-lysin antimicrobial peptides

Frontiers in Immunology
NK-lysin is a potent antimicrobial peptide (AMP) with antimicrobial activity against bacteria, fungi, viruses, and parasites. NK-lysin is a type of granulysin, a member of the saposin-like proteins family first isolated from a pig’s small intestine.
Leonardo Ortega, Crisleri Carrera, Carolina Muñoz-Flores, Santiago Salazar, Milton F. Villegas, María F. Starck, Ariel Valenzuela, Niza Agurto, Raquel Montesino, Allisson Astuya, Natalie Parra, Ercilia T. Pérez, Ercilia T. Pérez, Natacha Santibáñez, Natacha Santibáñez, Alex Romero, Alex Romero, Pamela Ruíz, Emilio Lamazares, Fátima Reyes, Oliberto Sánchez, Jorge R. Toledo, Jannel Acosta   +22 more
doaj   +1 more source

A Bioluminescence-Based Ex Vivo Burn Wound Model for Real-Time Assessment of Novel Phage-Inspired Enzybiotics

Pharmaceutics, 2022
The silent pandemic of antibiotic resistance is thriving, prompting the urgent need for the development of new antibacterial drugs. However, within the preclinical pipeline, in vitro screening conditions can differ significantly from the final in vivo ...
Vincent De Maesschalck, Diana Gutiérrez, Jan Paeshuyse, Yves Briers, Greetje Vande Velde, Rob Lavigne   +5 more
doaj   +1 more source

Characterization and genome sequencing of a Citrobacter freundii phage CfP1 harboring a lysin active against multidrug-resistant isolates [PDF]

, 2016
Citrobacter spp., although frequently ignored, is emerging as an important nosocomial bacterium able to cause various superficial and systemic life-threatening infections.
AE Darling, AM Kropinski, AM Kropinski, Ana Oliveira, AP Zavascki, Carla Oliveira, CM O’Hara, D Laslett, EW Myers, G Samonis, GB Edwards, GE Tusnady, Graça Pinto, H Kanamori, Hugo Oliveira, HW Ackermann, J Gu, J Soding, JD Bendtsen, JH Grose, JM Janda, Joana Azeredo, JRD Sambrook, K During, K Hwang, KC LeSage, KH Schleifer, L Kall, L Kall, L Poirel, Lucília Domingues, M Kearse, M Morita, M Perilli, M Thandar, M Walmagh, Maria Alberta Faustino, N Gupta, N Zafar, NK Petty, P Rice, P Schattner, P Stothard, R Lood, R Zhang, RK Aziz, RN Jones, S Sillankorva, SF Altschul, SJ Costa, SM Sillankorva, SR Lockhart, TI Doran, WN Chaudhry, X Zhao, Y Briers, Y Briers, YS Chen, Yves Briers, ZQ Xu   +59 more
core   +3 more sources

Ungesättigte Phosphor‐Elektrophile zur Untersuchung von Protein‐Tyrosin‐Phosphatasen

Angewandte Chemie, EarlyView.
Negativ geladene Aryl‐Ethynyl‐Phosphonamid‐ und Phosphonsäuren werden als reaktionsarme Elektrophile für peptidbasierte Aktivitätssonden eingeführt, die eine selektive, zielspezifische Profilierung von Protein‐Tyrosin‐Phosphatasen ermöglichen. Die Sonden zeigen keine Off‐Target‐Cystein‐Reaktivität und binden in der globalen Proteomanalyse nur an die ...
Eleftheria Poulou, Max Ruwolt, Christian E. Stieger, Kristin Kemnitz‐Hassanin, Christian P. R. Hackenberger   +4 more
wiley   +1 more source

Arthroscopic “Debridement and Implant Retention” With Local Administration of Exebacase (Lysin CF-301) Followed by Suppressive Tedizolid as Salvage Therapy in Elderly Patients for Relapsing Multidrug-Resistant S. epidermidis Prosthetic Knee Infection

Frontiers in Medicine, 2021
Exebacase, a recombinantly produced lysin has recently (i) reported proof-of-concept data from a phase II study in S. aureus bacteremia and (ii) demonstrated antibiofilm activity in vitro against S. epidermidis.
Tristan Ferry, Tristan Ferry, Tristan Ferry, Tristan Ferry, Cécile Batailler, Cécile Batailler, Cécile Batailler, Aubin Souche, Aubin Souche, Aubin Souche, Aubin Souche, Cara Cassino, Christian Chidiac, Christian Chidiac, Christian Chidiac, Thomas Perpoint, Thomas Perpoint, Claire le Corvaisier, Jérôme Josse, Jérôme Josse, Jérôme Josse, Jérôme Josse, Romain Gaillard, Julien Roger, Camille Kolenda, Camille Kolenda, Camille Kolenda, Camille Kolenda, Sébastien Lustig, Sébastien Lustig, Sébastien Lustig, Frédéric Laurent, Frédéric Laurent, Frédéric Laurent, Frédéric Laurent, The Lyon BJI Study Group   +35 more
doaj   +1 more source

Molecular evolution of candidate male reproductive genes in the brown algal model Ectocarpus [PDF]

, 2016
Background: Evolutionary studies of genes that mediate recognition between sperm and egg contribute to our understanding of reproductive isolation and speciation. Surface receptors involved in fertilization are targets of sexual selection, reinforcement,
De Clerck, Olivier, Lipinska, Agnieszka, Van Damme, Els   +2 more
core   +6 more sources