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Amino Acids, 2015
Determining the bioavailability of lysine in foods and feedstuffs is important since lysine is often the first limiting indispensable amino acid in diets for intensively farmed livestock (pigs and poultry) and also in many cereal-based diets consumed by humans.
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Determining the bioavailability of lysine in foods and feedstuffs is important since lysine is often the first limiting indispensable amino acid in diets for intensively farmed livestock (pigs and poultry) and also in many cereal-based diets consumed by humans.
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Biotechnological Manufacture of Lysine [PDF]
, 2002 L-Lysine has been manufactured using Corynebacterium glutamicum for more than 40 years. Nowadays production exceeds 600,000 tons per year. Based on conventionally bred strains, further improvement of lysine productivity has been achieved by genetic engineering.
Bettina Möckel +3 more
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Archives of Biochemistry and Biophysics, 1972
Abstract The metabolism of l -lysine, l -pipecolate, and saccharopine was studied in rabbits. The results indicated the existence of the same metabolic pathways as have been delineated in other species. The rabbit differed from the other species studied previously since saccharopine, l -pipecolate, and d -lysine were all readily converted to CO 2
John A. Grove +3 more
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Abstract The metabolism of l -lysine, l -pipecolate, and saccharopine was studied in rabbits. The results indicated the existence of the same metabolic pathways as have been delineated in other species. The rabbit differed from the other species studied previously since saccharopine, l -pipecolate, and d -lysine were all readily converted to CO 2
John A. Grove +3 more
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Lysine-Targeting Covalent Inhibitors.
Angewandte Chemie, 2017Targeted covalent inhibitors have gained widespread attention in drug discovery as a validated method to circumvent acquired resistance in oncology. This strategy exploits small-molecule/protein crystal structures to design tightly binding ligands with ...
Jonathan Pettinger +2 more
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Degradation of Lysine in Chicks
The Journal of Nutrition, 1972Lysine degradation in two strains of chicks selected for a high (HA) or low (LA) requirement of dietary arginine was investigated. These studies suggest that both an L-amino acid oxidase and lysine-ketoglutarate reduc Aaseare active in chick liver for the initial degradation of L-lysine, leading to the formation of pipecolic acid and saccharopine ...
Malden C. Nesheim, Shu-Heh Wang
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The path of lysine to pyrrolysine
Current Opinion in Chemical Biology, 2013Pyrrolysine is the 22nd genetically encoded amino acid. For many years, its biosynthesis has been primarily a matter for conjecture. Recently, a pathway for the synthesis of pyrrolysine from two molecules of lysine was outlined in which a radical SAM enzyme acts as a lysine mutase to generate a methylated ornithine from lysine, which is then ligated to
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Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Science, 2002R. Cao +7 more
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Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
Science, 2009Chunaram Choudhary +7 more
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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Nature, 2001M. Lachner +4 more
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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
Nature, 2001Andrew J. Bannister +6 more
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