Results 141 to 150 of about 1,236,497 (367)

True Love Is Requited: The Argument of Lysis 221d-222a [PDF]

open access: yes, 2004
I defend the argument in Plato's Lysis that true love is requited. I state the argument, the main objections, and my replies.
Rudebusch, George
core  

ICAM- melanoma cells are relatively resistant to CD3-mediated T-cell lysis [PDF]

open access: yes, 1990
The primary activation pathway of T cells is via the T-cell receptor (TCR)/CD3 complex, which is functionally interrelated with various accessory molecules.
Bolhuis, R.L.H. (Reinder)   +5 more
core   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

More than a Reductio: Plato's Method in the Parmenides and Lysis [PDF]

open access: yes, 2019
Plato’s Parmenides and Lysis have a surprising amount in common from a methodological standpoint. Both systematically employ a method that I call ‘exploring both sides’, a philosophical method for encouraging further inquiry and comprehensively ...
Rodriguez, Evan
core   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren   +16 more
wiley   +1 more source

Measurement Error Correction in Particle Tracking Microrheology [PDF]

open access: yesarXiv, 2019
In diverse biological applications, particle tracking of passive microscopic species has become the experimental measurement of choice -- when either the materials are of limited volume, or so soft as to deform uncontrollably when manipulated by traditional instruments.
arxiv  

THE LYSIS OF PSEUDOMONAS AERUGINOSA BY LYSOZYME [PDF]

open access: bronze, 1955
George H. Warren   +2 more
openalex   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

LocalCop: An R package for local likelihood inference for conditional copulas [PDF]

open access: yesarXiv
Conditional copulas models allow the dependence structure between multiple response variables to be modelled as a function of covariates. LocalCop (Acar & Lysy, 2024) is an R/C++ package for computationally efficient semiparametric conditional copula modelling using a local likelihood inference framework developed in Acar, Craiu, & Yao (2011), Acar ...
arxiv  

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