Developing a new treatment for superficial fungal infection using antifungal Collagen‐HSAF dressing [PDF]
Bioengineering & Translational Medicine, 2022 Fungal pathogens are common causes of superficial clinical infection. Their increasing drug resistance gradually makes existing antifungal drugs ineffective.
Jing Zhong +16 more
doaj +3 more sources
LesR is a novel upstream regulator that controls downstream Clp expression to modulate antibiotic HSAF biosynthesis and cell aggregation in Lysobacter enzymogenes OH11 [PDF]
Microbial Cell Factories, 2017 Background Heat-stable antifungal factor (HSAF) is a polycyclic tetramate macrolactam secondary metabolite that exhibits broad-spectrum inhibitory activities against filamentous fungal pathogens. The native yield of this chemical is low.
Huiyong Xu +5 more
doaj +2 more sources
Involvement of both PKS and NRPS in antibacterial activity in Lysobacter enzymogenes OH11. [PDF]
FEMS Microbiol Lett, 2014 Polyketides and nonribosomal peptides represent two large families of natural products (NPs) with diverse structures and important functions. They are synthesized by polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS), respectively. Lysobacter enzymogenes is emerging as a novel biocontrol agent against pathogens of crop plants and a ...
Zhang J +6 more
europepmc +4 more sources
Hfq regulates antibacterial antibiotic biosynthesis and extracellular lytic-enzyme production in Lysobacter enzymogenes OH11. [PDF]
Microb Biotechnol, 2015 Lysobacter enzymogenes is an important biocontrol agent with the ability to produce a variety of lytic enzymes and novel antibiotics. Little is known about their regulatory mechanisms. Understanding these will be helpful for improving biocontrol of crop diseases and potential medical application.
Xu G, Zhao Y, Du L, Qian G, Liu F.
europepmc +3 more sources
A YajQ-LysR-like, cyclic di-GMP-dependent system regulating biosynthesis of an antifungal antibiotic in a crop-protecting bacterium, Lysobacter enzymogenes. [PDF]
Mol Plant Pathol, 2020 Summary YajQ, a binding protein of the universal bacterial second messenger cyclic di‐GMP (c‐di‐GMP), affects virulence in several bacterial pathogens, including Xanthomonas campestris. In this bacterium, YajQ interacts with the transcription factor LysR.
Han S +6 more
europepmc +2 more sources
Microbiology Spectrum, 2023 Loss of flagellar genes causes a nonmotile phenotype. The genus Lysobacter consists of numerous environmentally ubiquitous, nonflagellated bacteria, including Lysobacter enzymogenes, an antifungal bacterium that is beneficial to plants. L.
Dan Xiong +10 more
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-Lactamase of Lysobacter Enzymogenes: Induction, Purification and Characterization [PDF]
Journal of General Microbiology, 1990 Lysobacter enzymogenes produces an inducible beta-lactamase and induction with 100 micrograms ampicillin ml-1 resulted in an increase of more than 100-fold in enzyme activity. Various other beta-lactam antibiotics also served as effective inducers.
R G, von Tigerstrom, G J, Boras
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PRODUCTION OF NEW WAP-8294A CYCLODEPSIPEPTIDES BY THE BIOLOGICAL CONTROL AGENT LYSOBACTER ENZYMOGENES OH11 [PDF]
Frontiers of Agricultural Science and Engineering, 2022 <List> <ListItem><ItemContent><p>● Lysobacter enzymogenes mutants were generated for WAP-8294A biosynthesis.</p></ItemContent></ListItem> <ListItem><ItemContent><p>● Essential and non-essential ...
Jing ZHU, Yuan CHEN, Liangcheng DU
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Phytopathology Research, 2023 Bacteria often use multiple transcription factors to regulate specific biological processes. Biosynthesis of heat-stable antifungal factor (HSAF) is regulated by multiple factors in Lysobacter enzymogenes.
Kaihuai Li +6 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2021 Acyl-homoserine lactone (AHL) is the most studied autoinducer in gram-negative bacteria controlling infections of various pathogens. Quenching of AHL signaling by inhibiting AHL synthesis or AHL-receptor binding via small molecular chemicals or ...
Jinxing Liao +8 more
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