Results 71 to 80 of about 7,486 (227)

Physiochemically and Genetically Engineered Bacteria: Instructive Design Principles and Diverse Applications

Advanced Science, Volume 11, Issue 30, August 14, 2024.
Engineered bacteria specifically refer to advanced physiochemical or genetic modifications of diagnostic bacteria, which can compensate for the shortcomings of natural strains. After engineering, these diagnostic bacteria are encouraged to lyse tumors, regulate immunity and cellular communication such immune cells, influence metabolic pathways ...
Xia Lin, Rong Jiao, Haowen Cui, Xuebing Yan, Kun Zhang   +4 more
wiley   +1 more source

LYSOGENIC CONVERSION IN PSEUDOMONAS AERUGINOSA [PDF]

Journal of Bacteriology, 1962
Holloway , B. W. (University of Melbourne, Victoria, Australia) and G. N. Cooper . Lysogenic conversion in Pseudomonas aeruginosa . J. Bacteriol. 84: 1321–1324. 1962.—When Pseudomonas aeruginosa strain 1 is lysogenized with phage D3,
B. W. Holloway, G. N. Cooper
openaire   +3 more sources

New functions of pirin proteins and a 2‐ketoglutarate: Ferredoxin oxidoreductase ortholog in Bacteroides fragilis metabolism and their impact on antimicrobial susceptibility to metronidazole and amixicile

MicrobiologyOpen, Volume 13, Issue 4, August 2024.
This study reveals that several enzymes involved in the central metabolism of Bacteroides fragilis are regulated by protein‐protein interactions with pirin proteins. We observed changes in susceptibility to the antimicrobials metronidazole and amixicile in various metabolic mutants.
Andrea M. Gough, Anita C. Parker, Patricia J. O'Bryan, Terence R. Whitehead, Sourav Roy, Brandon L. Garcia, Paul S. Hoffman, C. Jeffrey Smith, Edson R. Rocha   +8 more
wiley   +1 more source

Temperate Phages of Staphylococcus aureus

Microbiology spectrum, 2019
Most Staphylococcus aureus isolates carry multiple bacteriophages in their genome, which provide the pathogen with traits important for niche adaptation. Such temperate S. aureus phages often encode a variety of accessory factors that influence virulence,
H. Ingmer, D. Gerlach, C. Wolz
semanticscholar   +1 more source

Phages produce persisters

Microbial Biotechnology, Volume 17, Issue 8, August 2024.
Bacterial infections are predicted to be the main cause of death by 2050, and persister cells often form during periods of lethal stress. Here, we show phage infections generate persister cells, and these persisters may undermine phage therapy. Abstract Arguably, the greatest threat to bacteria is phages.
Laura Fernández‐García, Joy Kirigo, Daniel Huelgas‐Méndez, Michael J. Benedik, María Tomás, Rodolfo García‐Contreras, Thomas K. Wood   +6 more
wiley   +1 more source

Molecular Characteristics of Novel Phage vB_ShiP-A7 Infecting Multidrug-Resistant Shigella flexneri and Escherichia coli, and Its Bactericidal Effect in vitro and in vivo

Frontiers in Microbiology, 2021
In recent years, increasing evidence has shown that bacteriophages (phages) can inhibit infection caused by multidrug-resistant (MDR) bacteria. Here, we isolated a new phage, named vB_ShiP-A7, using MDR Shigella flexneri as the host.
Jing Xu, Jing Xu, Ruiyang Zhang, Ruiyang Zhang, Xinyan Yu, Xinyan Yu, Xuesen Zhang, Genyan Liu, Genyan Liu, Xiaoqiu Liu, Xiaoqiu Liu   +10 more
doaj   +1 more source

Inhibition of Lytic Induction in Lysogenic Cyanophyces [PDF]

Journal of Virology, 1977
When the lysogenic strain SPI cts 1 of the blue-green alga Plectonema boryanum carrying a temperature-sensitive mutation in the LPP2 prophage was heated at a nonpermissive temperature in the light, a lytic cycle occurred, with production of infectious viral particles.
C. Cocito, D. Goldstein
openaire   +2 more sources

Establishing a straightforward I‐SceI‐mediated recombination one‐plasmid system for efficient genome editing in P. putida KT2440

Microbial Biotechnology, Volume 17, Issue 7, July 2024.
In this study, we demonstrate a one‐plasmid genome editing tool, accelerating the engineering cycle from 9 to 3 days. Based on the pEMG backbone, a tightly controllable I‐sceI gene and a constitutive sacB gene were assembled on a single plasmid. The requirement of a second plasmid transformation and a laborious plasmid curing process was circumvented ...
Hao Meng, Sebastian Köbbing, Lars M. Blank   +2 more
wiley   +1 more source

More evolvable bacteriophages better suppress their host

Evolutionary Applications, Volume 17, Issue 7, July 2024.
Abstract The number of multidrug‐resistant strains of bacteria is increasing rapidly, while the number of new antibiotic discoveries has stagnated. This trend has caused a surge in interest in bacteriophages as anti‐bacterial therapeutics, in part because there is near limitless diversity of phages to harness.
Elijah K. Horwitz, Hannah M. Strobel, Jason Haiso, Justin R. Meyer   +3 more
wiley   +1 more source

Comparative genome analysis of three classical E. coli cloning strains designed for blue/white selection: JM83, JM109 and XL1‐Blue

FEBS Open Bio, Volume 14, Issue 6, Page 888-905, June 2024.
Based on their comparative genome analysis, JM83, JM109 and XL1‐Blue can be traced back to the classical research on the lac operon in the laboratory of F. Jacob. The Graphical Abstract depicts the genome map of JM83 superimposed on its colonies grown on an X‐gal agar plate transformed with a mixture of pUC19 plasmids with or without inserted ...
Stefan Achatz, Arne Skerra
wiley   +1 more source