Results 131 to 140 of about 39,604 (271)

Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF‐16

open access: yesThe FEBS Journal, EarlyView.
To investigate the impact of dietary components on animal growth, an Escherichia coli single‐gene deletion library was screened using the Caenorhabditis elegans growth model. Thirty‐four E. coli mutants were identified to delay worm development. Notably, E.
Min Feng   +3 more
wiley   +1 more source

Biophysical investigation of the molecular interaction between minichromosome maintenance protein 6 and Bloom syndrome helicase

open access: yesThe FEBS Journal, EarlyView.
This study reveals the interaction between minichromosome maintenance protein 6 (MCM6) and Bloom syndrome helicase (BLM), which is essential for DNA replication and cancer progression. Using fluorescence polarization anisotropy and NMR, we show the MCM6 winged‐helix domain (WHD) binds to the MCM6 binding domain D (MBD‐D) of BLM. MCM6 and BLM expression
Min June Yang   +3 more
wiley   +1 more source

Stabilization of the catalytically active structure of a molybdenum‐dependent formate dehydrogenase depends on a highly conserved lysine residue

open access: yesThe FEBS Journal, EarlyView.
Molybdenum‐dependent formate dehydrogenases (Mo‐FDHs) contain a strictly conserved lysine residue (K44) in the vicinity of an electron‐transferring [4Fe‐4S] cluster and a catalytically active molybdenum atom coordinated by two molybdopterins (MPT‐1 and MPT‐2).
Feilong Li, Michael Lienemann
wiley   +1 more source

Protein Homeostasis Impairment Alters Phenotypic Heterogeneity of Biofilm Communities

open access: yesMolecular Microbiology, EarlyView.
In biofilms, genetically identical cells exhibit diverse gene expression, resulting in subpopulations of functionally distinct and coexisting cell types, such as motile cells, extracellular matrix producers, and spores. Balanced phenotypic heterogeneity produces robust biofilms.
Judith Matavacas, Claes von Wachenfeldt
wiley   +1 more source

Elie Wollman and the question of lysogeny

open access: yesHistoire de la recherche contemporaine, 2018
The rise of Molecular Biology occurred in part via the spectacular convergence of few schools of thoughts located on each side of the Atlantic Ocean. This paper underlines the importance of the personal trajectory followed by Elie Wollman, as a shuttle between the Institut Pasteur and the Division of Biology of the California Institute of Technology in
openaire   +2 more sources

The Arms Race Between Actinobacillus pleuropneumoniae and Its Genetic Environment: A Comprehensive Analysis of Its Defensome and Mobile Genetic Elements

open access: yesMolecular Microbiology, EarlyView.
Using bioinformatic tools, we identified a diverse defensome in Actinobacillus pleuropneumoniae, featuring various defense mechanisms. Genomes show co‐occurring systems like CRISPR, Abi, and restriction‐modification (RM) systems, underscoring the complexity and dynamic nature of their defensome cargo.
Giarlã Cunha da Silva   +1 more
wiley   +1 more source

A novel uncultured marine cyanophage lineage with lysogenic potential linked to a putative marine Synechococcus 'relic' prophage [PDF]

open access: yes, 2019
Marine cyanobacteria are important contributors to primary production in the ocean and their viruses (cyanophages) affect the ocean microbial communities.
Béjà, Oded   +5 more
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