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Two pathways for lysophosphatidic acid production
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2008Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) is a simple phospholipid but displays an intriguing cell biology that is mediated via interactions with G protein-coupled seven transmembrane receptors (GPCRs). So far, five GPCRs, designated LPA1-5, and, more recently, two additional GPCRs, GPR87 and P2Y5, have been identified as ...
Junken, Aoki +2 more
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Lysophosphatidic acid induces osteocyte dendrite outgrowth
Biochemical and Biophysical Research Communications, 2007Osteocytes elaborate an extensive mechanosensory network in bone matrix and communicate intercellularly via gap junctions established at dendrite termini. We developed a method to measure osteocyte dendritogenesis in vitro using a modified transwell assay and determined that the lipid growth factor lysophosphatidic acid (LPA) is a potent stimulator of ...
Sue A, Karagiosis, Norman J, Karin
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Mitogenic Action of Lysophosphatidic Acid
1991Publisher Summary This chapter discusses the multiple biological effects of phosphatidic acid (PA) and lysophosphatidic acid (LPA), with particular emphasis on their growth factor-like activities. LPA and PA are the key intermediates in the early steps of phospholipid biosynthesis. They can exert their own biological effects. In particular, exogenous
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MicroRNAome genome: A treasure for cancer diagnosis and therapy
Ca-A Cancer Journal for Clinicians, 2014Ioana Berindan-Neagoe +2 more
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Advances in Prostate Cancer Chemotherapy: A New Era Begins
Ca-A Cancer Journal for Clinicians, 2005Kenneth J Pienta, David C Smith
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