2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition [PDF]
Scientific Reports, 2021 Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator that, along with its chemically stabilized analogue 2-carba-cyclic phosphatidic acid (2ccPA), induces various biological activities in vitro and in vivo.
Keiko Fukasawa +10 more
doaj +3 more sources
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies
Signal Transduction and Targeted Therapy, 2021 Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions both in development and in pathological conditions. Here, we review the literature about the differential signaling of LPA through its specific receptors, which ...
Luiz Henrique Medeiros Geraldo +8 more
doaj +2 more sources
Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid-lysophosphatidic acid receptor 1 cascade [PDF]
Arthritis Research & Therapy, 2014 INTRODUCTION: Lysophosphatidic acid (LPA) is a bioactive lipid that binds to G protein–coupled receptors (LPA(1–6)). Recently, we reported that abrogation of LPA receptor 1 (LPA(1)) ameliorated murine collagen-induced arthritis, probably via inhibition ...
Chie Miyabe +9 more
core +4 more sources
Pharmacological activation of lysophosphatidic acid receptors regulates erythropoiesis. [PDF]
Sci Rep, 2016 AbstractLysophosphatidic acid (LPA), a growth factor-like phospholipid, regulates numerous physiological functions, including cell proliferation and differentiation. In a previous study, we have demonstrated that LPA activates erythropoiesis by activating the LPA 3 receptor subtype (LPA3) under erythropoietin (EPO) induction.
Lin KH +14 more
europepmc +3 more sources
G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling. [PDF]
Int J Mol Sci, 2016 Riaz A, Huang Y, Johansson S.
europepmc +2 more sources
LPAR1 (lysophosphatidic acid receptor 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on LPAR1 (lysophosphatidic acid receptor 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Murph, MM, Radhakrishna, H
openaire +2 more sources
LPAR2 (lysophosphatidic acid receptor 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on LPAR2 (lysophosphatidic acid receptor 2), with data on DNA, on the protein encoded, and where the gene is implicated.
Knowlden, S, Georas, S
openaire +2 more sources
Ongoing Research on the Role of Gintonin in the Management of Neurodegenerative Disorders
Cells, 2020 Neurodegenerative disorders, namely Parkinson’s disease (PD), Huntington’s disease (HD), Alzheimer’s disease (AD), and multiple sclerosis (MS), are increasingly major health concerns due to the increasingly aged population worldwide.
Muhammad Ikram +3 more
doaj +1 more source
Linking medicinal cannabis to autotaxin–lysophosphatidic acid signaling
Life Science Alliance, 2023 The authors show that Δ9-trans-tetrahydrocannabinol, the main psychoactive compound in medicinal cannabis, could be considered as a therapeutic agent by inhibiting autotaxin–lysophosphatidic acid production. Autotaxin is primarily known for the formation
Mathias C Eymery +2 more
doaj +1 more source
Cells, 2021 Lysophosphatidic acid (LPA) is a bioactive lipid mediator primarily derived from membrane phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled receptors, termed LPA receptors (LPAR1 to LPAR6).
Yu-Hsuan Lin +2 more
doaj +1 more source