Results 91 to 100 of about 27,042 (202)

Reprogramming Glial Cell Metabolism via a tRNA Fragment Preserves Vision in Retinal Neurodegeneration

MedComm, Volume 7, Issue 8, August 2026.
Under oxidative and excitotoxic stress, Müller cell‐derived 5′tiRNA‐His‐GTG contributes to retinal neurodegeneration. Pathological stimuli increase ANG‐dependent production of 5′tiRNA‐His‐GTG, which suppresses LPCAT1 expression and disrupts phosphatidylcholine (PC)‐mediated glycerophospholipid metabolism.
Yuke Ji, Sha Liu, Ying Zhang, Junya Zhu, Chang Huang, Ya Zhao, Jiao Xia, Wan Mu, Jin Yao, Biao Yan   +9 more
wiley   +1 more source

Macrophage: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun, Linqing Wen, Shiyun Tang, Lu Liu, Nianzhi Chen   +4 more
wiley   +1 more source

The Dietary Protein Source Modulates Obesity Development and Induces Distinct Plasma Lipid Profiles and Transcriptome Profiles in Liver and Adipose Tissue

Molecular Nutrition &Food Research, Volume 70, Issue 15, 17 August 2026.
By performing plasma metabolomics analyses combined with RNA sequencing and gene set enrichment analyses of liver, muscle, white‐ and brown‐adipose tissue in mice, we aimed to decipher the metabolic output and pathways modulated by intake of different dietary proteins.
Lene S. Myrmel, Even Fjære, Annette Bernhard, Josef D. Rasinger, Ole Jakob Nøstbakken, Helene Søiland, Philipp Rausch, Martin von Bergen, Ulrike Rolle‐Kampzcyk, Liang Xiao, Hanlin Zhou, Guibo Li, Karsten Kristiansen, Lise Madsen   +13 more
wiley   +1 more source

Isothiocyanates as Ferroptosis Inducers to Promote Cancer Cell Death

Phytotherapy Research, Volume 40, Issue 8, Page 5119-5131, August 2026.
ABSTRACT Cancer remains a leading cause of global mortality, with the therapeutic efficacy of anticancer drugs often hampered by late diagnosis and the development of chemotherapy resistance. Ferroptosis is an iron‐dependent form of regulated non‐apoptotic cell death driven by lipid peroxidation.
Valentina Citi, Renda Chahna, Francesca Maffei, Alma Martelli, Vincenzo Calderone, Carmela Fimognari, Eleonora Turrini   +6 more
wiley   +1 more source

Adolescent Dietary Supplementation of Omega‐3 Polyunsaturated Fatty Acids Alleviates PTSD‐Like Fear Memory and Affective Dysregulation in Rats

Smart Medicine, Volume 5, Issue 4, August 2026.
Adolescent omega‐3 polyunsaturated fatty acid supplementation enhances resilience to trauma in adulthood. DHA/EPA intake restores gut microbial balance, reprograms lipid metabolism, and normalizes prefrontal PI3K/AKT/mTOR signaling. These changes may collectively mitigate PTSD‐like fear memory and affective dysregulation. ABSTRACT Post‐traumatic stress
Wenjing Li, Yi Yin, Jie Li, Ziwei Yao, Siqi Wang, Yinan Jin, Lihua Bian, Jianyou Guo   +7 more
wiley   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, Volume 293, Issue 15, Page 4554-4577, August 2026.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Lysophosphatidylcholin [PDF]

, 2018
K. J. Lackner, D. Peetz
openaire   +2 more sources

Possible Involvement of Lysophospholipids in Severe Asthma as Novel Lipid Mediators

Biomolecules
In severe asthma, symptoms are unstable despite intensive treatment based on high doses of inhaled corticosteroids and on-demand use of oral corticosteroids.
Hiroaki Kume, Kentaro Kazama, Riko Sato, Yuki Sato   +3 more
doaj   +1 more source

Effects of lysophosphatidylcholine on growth performance， serum biochemical indicators， liver morphology， and intestinal health in Micropterus salmoides fed low-fat diet

Siliao yanjiu
The experiment aimed to investigate the effects of dietary supplementation with lysophosphatidylcholine (LPC) in low-fat diets on the growth performance, serum biochemical indicators, liver morphology, and intestinal health of Micropterus salmoides.
WEI Yuqiang, LIU Xiaochuan, BI Yulin, ZHAO Jianguo, ZHOU Zhihao, XU Qiyou   +5 more
doaj  

Predictive Value of Lysophosphatidylcholine for Determining the Disease Severity and Prognosis of Elderly Patients with Community-Acquired Pneumonia

Clinical Interventions in Aging
Minghao Gu,1,2 SenSen Lv,1 Yihui Song,3 Hong Wang,4 Xingyu Zhang,5 Jing Liu,1 Deshun Liu,1 Xiudi Han,1 Xuedong Liu1 1Department of Respiratory and Critical Care Medicine, Qingdao Municipal Hospital, Qingdao, 266011, People’s Republic of China; 2School of
Gu M, Lv S, Song Y, Wang H, Zhang X, Liu J, Liu D, Han X, Liu X   +8 more
doaj