Results 101 to 110 of about 32,338 (252)

The chemical synthesis and cytotoxicity of new sulfur analogues of 2-methoxy-lysophosphatidylcholine

, 2013
The chemical synthesis of phosphorothioate/phosphorodithioate analogues of 2-methoxy-lysophosphatidylcholine has been described. For the preparation of new sulfur derivatives of lysophosphatidylcholine both oxathiaphospholane and dithiaphospholane ...
Gendaszewska-Darmach, Edyta, Okruszek, Andrzej, Drzazga, Anna, Rytczak, Przemysław   +3 more
core   +1 more source

The Role of Ferroptosis Induced by Iron Overload in Osteoblast and Osteoclast Function

Cell Biology International, Volume 50, Issue 10, October 2026.
ABSTRACT Iron overload disrupts bone homeostasis by suppressing osteoblast survival and mineralization, while promoting osteoclastogenesis. As a programmed cell death driven by iron‐dependent lipid peroxidation and glutathione peroxidase 4 (GPX4) downregulation. This study investigated the role of ferroptosis in bone cells under iron overload. Exposure
Supagarn Sooksawanwit, Kornkamon Lertsuwan, Natnicha Tannop, Ploypapus Lapatkeattisukul, Thanayuth Jenpichitkulchai, Nittiyaporn Sotapong, Jarinthorn Teerapornpuntakit, Tueanjai Khunluck, Siriwan Punvilai, Narattaphol Charoenphandhu   +9 more
wiley   +1 more source

Hyperglycemia‐Induced Microglial CTSS Disrupts Blood‐Retinal Barrier Integrity via PAR2‐Dependent Downregulation of Endothelial MFSD2A

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Hyperglycemia induces retinal microglial activation and CTSS upregulation, disrupting microglia‐endothelial crosstalk via PAR2‐dependent MFSD2A suppression. Abnormal activation of microglia amplifies retinal inflammatory cascade, enhances transcytosis, compromises BRB integrity, and accelerates DR progression.
Chengye Xu, Hongxue Li, Qian Xu, Kangqi Zhao, Yangwen Chen, Yan Wang, Wei Zou, Binglin Kuang, Hongyu Kuang   +8 more
wiley   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

Factors regulating the secretion of lysophosphatidylcholine by rat hepatocytes compared with the synthesis and secretion of phosphatidylcholine and triacylglycerol. Effects of albumin, cycloheximide, verapamil, EGTA and chlorpromazine [PDF]

, 1988
1. The synthesis and secretion of glycerolipid by monolayer cultures of rat hepatocytes was measured by determining the incorporations of [3H]glycerol, [3H]oleate and [14C]choline and by the absolute concentration of triacylglycerol. 2.
V A Zammit, Bennett, Andrew J., McLean, A. Alexandra M., Brindley, David N., Graham, Annette, Zammit, Victor A., A Graham, D N Brindley, A J Bennett, A A M McLean   +9 more
core   +1 more source

Mutual antagonism between auxin and diacylglycerol acyltransferase 2 regulates high‐temperature‐induced hypocotyl elongation

New Phytologist, Volume 252, Issue 1, Page 222-240, October 2026.
Proposed model for auxin–DGAT2 crosstalk regulating high‐temperature‐induced hypocotyl elongation. Summary Cell elongation is a fundamental process in plant growth and development, and it is significantly affected by temperature changes. While the signaling mechanisms driving high‐temperature‐induced cell elongation have been extensively studied, the ...
Mohinur Khamzaaliyeva, Punita Lalchand, Didier‐Deschamps Ashley, Xue Pan   +3 more
wiley   +1 more source

A VSV-G Pseudotyped Last Generation Lentiviral Vector Mediates High Level and Persistent Gene Transfer in Models of Airway Epithelium In Vitro and In Vivo

Viruses, 2010
The aim of this work was to evaluate the efficiency and duration of gene expression mediated by a VSV-G pseudotyped last generation lentiviral (LV) vector.
Massimo Conese, Stefano Castellani, Lucia Palmieri, Elena Copreni   +3 more
doaj   +1 more source

Synthesis of Novel Lysophosphatidylcholine Analogues Using Serine as Chiral Template

, 2020
Four novel lysophosphatidylcholine (lysoPC) analogues, (S)-N-stearoyl-O-phosphocholineserine methyl ester [(S)-1a], (R)-1-lyso-2-stearoylamino-2-deoxy-sn-glycero-3-phosphatidylcholine [(R)-2a], (R)-N-stearoyl-O-phosphocholineserine methyl ester [(R)-1b],
한소엽, 최원자, 전길자
core   +1 more source

Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression in human colorectal cancer [PDF]

, 2009
The alteration of the choline metabolite profile is a well-established characteristic of cancer cells. In colorectal cancer (CRC), phosphatidylcholine is the most prominent phospholipid.
da Costa, Kerry-Ann, Mansilla, Francisco, Lewin, Tal M., Coleman, Rosalind A., Birkenkamp-Demtröder, Karin, Ørntoft, Torben F., Wang, Shuli, Kruhøffer, Mogens   +7 more
core   +1 more source

Transcriptomic and Metabolomic Profiling Identifies a Core Gene–Metabolite Axis Driving African Swine Fever Virus Replication in the Soft Tick Ornithodoros lahorensis

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Transcriptomic and metabolomic profiling of Ornithodoros lahorensis during African swine fever virus (ASFV) infection reveals that ASFV rewires host purine/pyrimidine metabolism, lipid metabolism, and energy metabolism. A core gene‐metabolite regulatory axis consisting of 12 key genes and 8 signature metabolites is identified to support viral genome ...
Jin Luo, Kaifei Guo, Fangyu Xiao, Ruoqi Wang, Junhui Guo, Qiaoyun Ren, Shuaiyang Zhao, Muhammad Kashif Obaid, Guiquan Guan, Hong Yin   +9 more
wiley   +1 more source