Results 211 to 220 of about 32,338 (252)

Synthesis of a Novel Lysophosphatidylcholine

Journal of Natural Products, 2000
The novel lysophosphatidylcholine (1), which naturally occurs in the marine sponge Spirastrella abata and was reported to inhibit cholesterol biosynthesis in the Chang liver cell, has been synthesized in four steps from methyl cis-11-octadecenoate (2).
C, Zhu, T, Morimoto, S, Nakajima, T, Nitoda, N, Baba   +4 more
openaire   +2 more sources

Association of cholesterol with lysophosphatidylcholine

Chemistry and Physics of Lipids, 1983
With equimolar cholesterol, lysophosphatidylcholine (lysoPC) or 1-ether-2-deoxylyso-phosphatidylcholine (etherdeoxylysoPC) form unilamellar vesicles of identical dimensions. 13C-NMR spectra of such vesicles are interpreted on the premise that suppression of a signal by broadening (i.e.
L S, Ramsammy, H, Volwerk, L C, Lipton, H, Brockerhoff   +3 more
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Lysophosphatidylcholine as a ligand for immunoregulation

Biochemical Pharmacology, 2002
Despite the recognized effects of lysophosphatidylcholine upon cells of the immune system and its association with inflammatory processes, its mechanism of action has remained poorly characterized. Our recent identification of the first lysophosphatidylcholine receptor as an immunoregulatory G protein-coupled receptor named G2A whose genetic ablation ...
Janusz H S, Kabarowski, Yan, Xu, Owen N, Witte   +2 more
openaire   +2 more sources

The mechanisms of lysophosphatidylcholine in the development of diseases

Life Sciences, 2020
Lysophosphatidylcholine (LPC) is the main component of oxidatively damaged low-density lipoprotein (oxLDL). LPC originates from the cleavage of phosphatidylcholine by phospholipase A2 (PLA2). LPC plays a biological role by binding to G protein-coupled receptors and Toll-like receptors.
Panpan, Liu, Wu, Zhu, Chao, Chen, Bei, Yan, Lei, Zhu, Xiang, Chen, Cong, Peng   +6 more
openaire   +2 more sources

Lysophosphatidylcholine causes cardiac arrhythmia

Journal of Molecular and Cellular Cardiology, 1982
Abstract The precipitation of malignant cardiac arrhythmias after onset of ischemia is well-documented [7]. Although many biochemical and physiological changes were observed during ischemia, the exact cause for disturbances in cardiac rhythm after ischemia remains obscure.
Choy, PC, Man, RYK
openaire   +5 more sources

Prevention of 1-palmitoyl lysophosphatidylcholine-induced inflammation by polyunsaturated acyl lysophosphatidylcholine

Inflammation Research, 2012
The aim of this study was to examine the inflammation induced by saturated acyl lysophosphatidylcholine (LPC) in vivo and to investigate whether it could be attenuated by the action of polyunsaturated acyl lysophosphatidylcholines (LPCs), which are known as anti-inflammatory lipid mediators.First, saturated acyl LPC was administered intraperitoneally ...
Nguyen Dang, Hung, Dai-Eun, Sok, Mee Ree, Kim   +2 more
openaire   +2 more sources

Characterisation of brain D2 dopamine receptors solubilised by lysophosphatidylcholine [PDF]

FEBS Letters, 1983
Brain D2 dopamine receptors have been solubilised using lysophosphatidylcholine. The inclusion of proteinase inhibitors during solubilisation enables a preparation to be obtained containing a high proportion of solubilised D2 receptors with ...
M Wheatley, Philip G Strange, P G Strange   +2 more
exaly   +2 more sources

Metabolism of lysophosphatidylcholine by swine platelets

Lipids, 1985
AbstractIncubation of intact platelets from Sinclair(S‐1) miniature swine with32P‐labeled lysophosphatidylcholine (lyso PC) indicated the presence of an active lysophospholipase with a pH optimum of 8.0 for hydrolysis of the substrate. However, lyso PC was incorporated into the membrane phosphatidylcholines by the acyltransferase pathway upon addition ...
D E, Chen, A A, White, M E, Tumbleson, G Y, Sun   +3 more
openaire   +2 more sources

Acylation of lysophosphatidylcholine by brain membranes

Journal of Neuroscience Research, 1993
AbstractBrain microsomes catalyze the acylation of lysophosphatidylcholine (lysoPtdCho) in the presence and absence of added CoA derivatives. The catalytic activity is distributed widely in various subcellular fractions from rat or bovine cerebral cortex as measured by the conversion of 1‐[14C] palmitoyl‐sn‐glycero‐3‐phosphocholine to [14C]PtdCho ...
N, Premkumar, G Y, Sun, R A, MacQuarrie
openaire   +2 more sources

Inhibition of Membrane Fusion by Lysophosphatidylcholine

Biochemistry, 1994
The ability of lysophosphatidylcholine to inhibit membrane fusion at subsolubilizing concentrations (between 1 and 9 mol % with respect to the membrane lipids) was examined. Fusion between N-methyldioleoylphosphatidylethanolamine (DOPE) large unilamellar vesicles (LUV) and fusion between Sendai virus and N-methyl-DOPE LUV were measured.
P L, Yeagle, F T, Smith, J E, Young, T D, Flanagan   +3 more
openaire   +2 more sources