Results 211 to 220 of about 39,809 (251)

Mechanism of Lysophosphatidylcholine-Induced Lysosome Destabilization

Journal of Membrane Biology, 2007
Lysosomal destabilization is critical for the organelle and living cells. Phospholipase A(2 )(PLA(2)) was shown to be able to destabilize lysosomes under some conditions. By what mechanism the enzyme affects lysosomal stability is not fully studied. In this study, we investigated the effects of lysophosphatidylcholine (lysoPC), a PLA(2)-produced lipid ...
Jin-Shan, Hu, Ying-Bin, Li, Jiong-Wei, Wang, Lin, Sun, Guo-Jiang, Zhang   +4 more
openaire   +2 more sources

Penetration of Lysophosphatidylcholine into the Dermis

The Journal of Dermatology, 1991
AbstractThe ability of Lysophosphatidylcholine (LPC) to penetrate into the dermis and its degradation were investigated in vivo using hairless rats. Phosphatidylcholine (PC) was used as a control. Radioactively labelled LPC and PC were applied on the surface of skin, and the radioactivities of the epidermis and dermis were measured at 8, 24, and 48 ...
Y, Uchida, T, Ogawa, M, Ohta, M, Kondo, S, Takada, M, Yamamura   +5 more
openaire   +2 more sources

Lysophosphatidylcholine Induces Apoptosis in AR42J Cells

Pancreas, 2001
Phospholipase A2 (PLA2) has been suggested to play an important role in the pathogenesis of acute pancreatitis, in part through the PLA2-generated phospholipid by-products, most notably lysophosphatidylcholine (lyso-PC). The effects of lyso-PC on pancreatic acinar cells, other than the induction of necrosis, are poorly characterized.
A, Masamune, Y, Sakai, A, Satoh, M, Fujita, M, Yoshida, T, Shimosegawa   +5 more
openaire   +2 more sources

Inhibition of Membrane Fusion by Lysophosphatidylcholine

Biochemistry, 1994
The ability of lysophosphatidylcholine to inhibit membrane fusion at subsolubilizing concentrations (between 1 and 9 mol % with respect to the membrane lipids) was examined. Fusion between N-methyldioleoylphosphatidylethanolamine (DOPE) large unilamellar vesicles (LUV) and fusion between Sendai virus and N-methyl-DOPE LUV were measured.
P L, Yeagle, F T, Smith, J E, Young, T D, Flanagan   +3 more
openaire   +2 more sources

[8] Lysophosphatidylcholine acyltransferase

1992
Publisher Summary This chapter discusses lysophosphatidylcholine acyltransferase. Lyso-PC:acyl-CoA acyltransferase activity is detected in various mammalian tissues, bacteria, protozoa, and plants. The transfer of acyl groups from acyl-CoA to 1-acylglycerophosphocholine (1-acyl-GPC) is catalyzed by 1-acyl-GPC: acyl-CoA acyltransferase, whereas ...
Patrick C. Paul, G. Tardi, J.J. Mukherjee   +2 more
openaire   +1 more source

Lysophosphatidylcholine as a ligand for immunoregulation

Biochemical Pharmacology, 2002
Despite the recognized effects of lysophosphatidylcholine upon cells of the immune system and its association with inflammatory processes, its mechanism of action has remained poorly characterized. Our recent identification of the first lysophosphatidylcholine receptor as an immunoregulatory G protein-coupled receptor named G2A whose genetic ablation ...
Janusz H S, Kabarowski, Yan, Xu, Owen N, Witte   +2 more
openaire   +2 more sources

Role of Lysophosphatidylcholine (LPC) in Atherosclerosis

Current Medicinal Chemistry, 2007
Lysophosphatidylcholine (LPC) is a bioactive proinflammatory lipid generated by pathological activities. LPC is also a major phospholipid component of oxidized low-density lipoprotein (Ox-LDL) and is implicated as a critical factor in the atherogenic activity of Ox-LDL.
Takayuki, Matsumoto, Tsuneo, Kobayashi, Katsuo, Kamata   +2 more
openaire   +2 more sources

Acylation of lysophosphatidylcholine by brain membranes

Journal of Neuroscience Research, 1993
AbstractBrain microsomes catalyze the acylation of lysophosphatidylcholine (lysoPtdCho) in the presence and absence of added CoA derivatives. The catalytic activity is distributed widely in various subcellular fractions from rat or bovine cerebral cortex as measured by the conversion of 1‐[14C] palmitoyl‐sn‐glycero‐3‐phosphocholine to [14C]PtdCho ...
N, Premkumar, G Y, Sun, R A, MacQuarrie
openaire   +2 more sources

Metabolism of lysophosphatidylcholine by swine platelets

Lipids, 1985
AbstractIncubation of intact platelets from Sinclair(S‐1) miniature swine with32P‐labeled lysophosphatidylcholine (lyso PC) indicated the presence of an active lysophospholipase with a pH optimum of 8.0 for hydrolysis of the substrate. However, lyso PC was incorporated into the membrane phosphatidylcholines by the acyltransferase pathway upon addition ...
D E, Chen, A A, White, M E, Tumbleson, G Y, Sun   +3 more
openaire   +2 more sources

Increased platelet membrane lysophosphatidylcholine in schizophrenia

Biological Psychiatry, 1991
Disturbances in phospholipid metabolism have been suggested in schizophrenia (Rotrosen and Wolkin 1987; Brody et al 1987). There is increasing evidence from numerous studies on blood cells, mostly erythrocytes and platelets, that membrane phospholipid distribution is changed in schizophrenic patients, however, results are not consistent.
A M, Pangerl, A, Steudle, H W, Jaroni, R, Rüfer, W F, Gattaz   +4 more
openaire   +2 more sources