Results 221 to 230 of about 32,338 (252)
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Role of Lysophosphatidylcholine (LPC) in Atherosclerosis
Current Medicinal Chemistry, 2007Lysophosphatidylcholine (LPC) is a bioactive proinflammatory lipid generated by pathological activities. LPC is also a major phospholipid component of oxidized low-density lipoprotein (Ox-LDL) and is implicated as a critical factor in the atherogenic activity of Ox-LDL.
Takayuki, Matsumoto +2 more
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Activation of peritoneal macrophages by lysophosphatidylcholine
Biochimica et Biophysica Acta (BBA) - General Subjects, 1985Lysophosphatidylcholine (lyso-PC), a product of inflammation induced by infectious and other agents, is able to stimulate mouse peritoneal macrophages to ingest target cells coated with IgG but not IgM regardless of the presence of complement. In vitro treatment of mouse resident peritoneal macrophages (adherent cells) alone with lyso-PC stimulated ...
B Z, Ngwenya, N, Yamamoto
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Lysophosphatidylcholine and the inflammatory action of neutrophils
Scandinavian Journal of Clinical and Laboratory Investigation, 1988Lysophosphatidylcholine (lysoPC) is a polar lipid formed in cells and tissues under normal conditions and is known to cause tissue damage in a variety of experimental systems. We have therefore examined the possibility that increased amounts of lysoPC are formed in activated inflammatory cells and are involved in their tissue-damaging action.
M, Lindahl, R, Bruhn, C, Tagesson
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Enzyme affinity in the acylation of lysophosphatidylcholine
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1977Analogues of 1-palmitoyl-sn-glycero-3-phosphorylcholine were used to ascertain the respective roles of the 1-palmitoyl-sn-glycero and choline groups in binding this substrate to the transferase catalyzing the acylation reaction. 1-Palmitoyl-sn-glycero-3-phosphorylhomocholine proved to be an effective competitive inhibitor whereas 1-palmitoyl-2 ...
B, Wittels, S, Hurlbert
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A sensitive, radiometric assay for lysophosphatidylcholine
Analytical Biochemistry, 1990To facilitate investigation of the metabolism of lysophosphatidylcholine and choline lysoplasmalogen in small quantities of tissue, a method for the quantification of these phospholipid species that is capable of accurate and reproducible analysis in samples which contain less than 1 nmol of total choline lysophospholipid was developed.
D J, Dobmeyer, P B, Corr, M H, Creer
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Effect of lysophosphatidylcholine on atherosclerotic rabbit arteries
Atherosclerosis, 1989We report here on the effect of an endothelium-dependent vascular smooth muscle relaxant, lysophosphatidylcholine (LPC) on rabbit aortic strips and on hemodynamic changes by LPC in atherosclerotic animals. Cyclic GMP changes induced by LPC in atherosclerotic vessels were also determined.
A, Wolf +4 more
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The hypotonic hemolysis and the protective action of lysophosphatidylcholine
Biorheology, 1984Lysophosphatidylcholine (LPC) protected against hypotonic hemolysis during rapid swelling of erythrocytes in spherocytic concentrations without any increase in the maximal cell volume. The total prelytic potassium release was increased, but the prelytic potassium release per cell was the same or decreased in the presence of LPC.
S, Eskelinen, P, Saukko
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Lysophosphatidylcholine: an enigmatic lysolipid
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2005increased endothelial permeability of pulmonary microvessels is the major contributor of acute lung injury, sepsis, and acute respiratory distress syndrome ([2][1], [7][2]). Studies have established that change in cell shape resulting in concurrent formation of gaps between endothelial cells is ...
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[8] Lysophosphatidylcholine acyltransferase
1992Publisher Summary This chapter discusses lysophosphatidylcholine acyltransferase. Lyso-PC:acyl-CoA acyltransferase activity is detected in various mammalian tissues, bacteria, protozoa, and plants. The transfer of acyl groups from acyl-CoA to 1-acylglycerophosphocholine (1-acyl-GPC) is catalyzed by 1-acyl-GPC: acyl-CoA acyltransferase, whereas ...
Patrick C. Paul +2 more
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