Results 221 to 230 of about 39,610 (238)
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Lysophosphatidylcholine as a ligand for immunoregulation
Biochemical Pharmacology, 2002Despite the recognized effects of lysophosphatidylcholine upon cells of the immune system and its association with inflammatory processes, its mechanism of action has remained poorly characterized. Our recent identification of the first lysophosphatidylcholine receptor as an immunoregulatory G protein-coupled receptor named G2A whose genetic ablation ...
Janusz H S, Kabarowski +2 more
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Role of Lysophosphatidylcholine (LPC) in Atherosclerosis
Current Medicinal Chemistry, 2007Lysophosphatidylcholine (LPC) is a bioactive proinflammatory lipid generated by pathological activities. LPC is also a major phospholipid component of oxidized low-density lipoprotein (Ox-LDL) and is implicated as a critical factor in the atherogenic activity of Ox-LDL.
Takayuki, Matsumoto +2 more
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Acylation of lysophosphatidylcholine by brain membranes
Journal of Neuroscience Research, 1993AbstractBrain microsomes catalyze the acylation of lysophosphatidylcholine (lysoPtdCho) in the presence and absence of added CoA derivatives. The catalytic activity is distributed widely in various subcellular fractions from rat or bovine cerebral cortex as measured by the conversion of 1‐[14C] palmitoyl‐sn‐glycero‐3‐phosphocholine to [14C]PtdCho ...
N, Premkumar, G Y, Sun, R A, MacQuarrie
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Metabolism of lysophosphatidylcholine by swine platelets
Lipids, 1985AbstractIncubation of intact platelets from Sinclair(S‐1) miniature swine with32P‐labeled lysophosphatidylcholine (lyso PC) indicated the presence of an active lysophospholipase with a pH optimum of 8.0 for hydrolysis of the substrate. However, lyso PC was incorporated into the membrane phosphatidylcholines by the acyltransferase pathway upon addition ...
D E, Chen +3 more
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Increased platelet membrane lysophosphatidylcholine in schizophrenia
Biological Psychiatry, 1991Disturbances in phospholipid metabolism have been suggested in schizophrenia (Rotrosen and Wolkin 1987; Brody et al 1987). There is increasing evidence from numerous studies on blood cells, mostly erythrocytes and platelets, that membrane phospholipid distribution is changed in schizophrenic patients, however, results are not consistent.
A M, Pangerl +4 more
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A sensitive, radiometric assay for lysophosphatidylcholine
Analytical Biochemistry, 1990To facilitate investigation of the metabolism of lysophosphatidylcholine and choline lysoplasmalogen in small quantities of tissue, a method for the quantification of these phospholipid species that is capable of accurate and reproducible analysis in samples which contain less than 1 nmol of total choline lysophospholipid was developed.
D J, Dobmeyer, P B, Corr, M H, Creer
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Activation of peritoneal macrophages by lysophosphatidylcholine
Biochimica et Biophysica Acta (BBA) - General Subjects, 1985Lysophosphatidylcholine (lyso-PC), a product of inflammation induced by infectious and other agents, is able to stimulate mouse peritoneal macrophages to ingest target cells coated with IgG but not IgM regardless of the presence of complement. In vitro treatment of mouse resident peritoneal macrophages (adherent cells) alone with lyso-PC stimulated ...
B Z, Ngwenya, N, Yamamoto
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Lysophosphatidylcholine: an enigmatic lysolipid
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2005increased endothelial permeability of pulmonary microvessels is the major contributor of acute lung injury, sepsis, and acute respiratory distress syndrome ([2][1], [7][2]). Studies have established that change in cell shape resulting in concurrent formation of gaps between endothelial cells is ...
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Lysophosphatidylcholine acyltransferases activity during experimental cholelithiasis
Lipids, 1981AbstractThe accumulation of (1‐palmitoyl)lysophosphatidylcholine, lysolecithin, in gallbladder bile was observed during the first week of cholesterol‐induced experimentals cholelithiasis using the prairie dog model for cholesterol gallstone formation. Gallbladder fluid transport function decreased as bile lysolecithin concentration increased.
F A, Rutledge +4 more
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Lysophosphatidylcholine accumulation in the ischemic canine heart
Lipids, 1988AbstractThe production of cardiac arrhythmias and the elevation of lysophosphatidylcholine level in the ischemic myocardium have been well‐documented in a number of studies. However, the relationship between the production arrhythmias and the elevation of tissue lysophosphatidylcholine level was not reported.
Kinnaird, AAA, Choy, PC, Man, RYK
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