Results 151 to 160 of about 7,434 (235)

Tks4‐Targeted Gene Therapy Inhibited White Adipocyte Hypertrophy in Mice

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Tks4 knockout or knockdown by AAV mediated shRNA both successfully restricted adipocyte hypertrophy in high fat diet. The reduction of TAG was validated by biochemistry and lipidomics analyses. This study suggested a potential of Tks4 targeted therapy in obesity intervention. ABSTRACT Obesity is one of the most prevalent public health issues worldwide,
Meng Tian, Jingwen Deng, Yuzhu Hong, Ruitong Liu, Shengnan Li, Xiaoxiao He   +5 more
wiley   +1 more source

Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19

npj Biofilms and Microbiomes
The clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis that disease progression and inflammatory responses associate with alterations in the microbiome and metabolome, we analyzed metagenome, metabolome, cytokine, and
Morgan Essex, Belén Millet Pascual-Leone, Ulrike Löber, Mathias Kuhring, Bowen Zhang, Ulrike Brüning, Raphaela Fritsche-Guenther, Marta Krzanowski, Facundo Fiocca Vernengo, Sophia Brumhard, Ivo Röwekamp, Agata Anna Bielecka, Till Robin Lesker, Emanuel Wyler, Markus Landthaler, Andrej Mantei, Christian Meisel, Sandra Caesar, Charlotte Thibeault, Victor M. Corman, Lajos Marko, Norbert Suttorp, Till Strowig, Florian Kurth, Leif E. Sander, Yang Li, Jennifer A. Kirwan, Sofia K. Forslund, Bastian Opitz   +28 more
doaj   +1 more source

Charting the metabolic biogeography of the colorectum in cancer: challenging the right sided versus left sided classification

Molecular Cancer
Objective Colorectal cancer (CRC) is conventionally classified as right sided, left sided, and rectal cancer. Clinicopathological, molecular features and risk factors do not change abruptly along the colorectum, and variations exist even within the ...
Abhishek Jain, Montana T. Morris, Domenica Berardi, Trisha Arora, Xavier Domingo-Almenara, Philip B. Paty, Nicholas J. W. Rattray, Daniel Kerekes, Lingeng Lu, Sajid A. Khan, Caroline H. Johnson   +10 more
doaj   +1 more source

Lysophosphatidylcholine Acyltransferase 1 [PDF]

, 2020
openaire   +1 more source

Lysophosphatidylcholines are associated with amyloidosis in early stages of Alzheimer's disease. [PDF]

Nat Aging
Kalia V, Reyes-Dumeyer D, Dubey S, Udhani H, Nandakumar R, Lee AJ, Lantigua R, Medrano M, Rivera D, Honig LS, Mayeux R, Miller GW, Vardarajan BN.   +12 more
europepmc   +1 more source

Serum metabolomic-lipidomic signatures track long-term neurological performance in multiple sclerosis. [PDF]

Mol Neurodegener Adv
Noroozi R, Tsai HH, Yu K, Samuel K, Trinh K, Tsai EA, Briggs FBS, Bhargava P, Fitzgerald KC.   +8 more
europepmc   +1 more source

Heart failure–induced activation of phospholipase iPLA2γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore [PDF]

, 2018
Cedars, Ari M., Gross, Richard W., Jenkins, Christopher M., Joseph, Susan M., Kelley, John, Kiebish, Michael A., Liu, Xinping, Moon, Sung Ho, Yang, Kui   +8 more
core   +2 more sources

Empagliflozin-induced lipidome remodeling in type 2 diabetes: mechanistic insights and translational perspectives. [PDF]

Cardiovasc Diabetol
Izzo C, Carrizzo A.
europepmc   +1 more source

Stocking density modulates tilapia (Oreochromis niloticus) performance and fillet quality through phospholipid remodeling. [PDF]

Sci Rep
Roldi G, Robath S, Porto C, Pilau E, Giaquinto P, Neto JF, Lala B, Mari GC, Santos CT, Anastácio GN, Cangianelli GH, Ferreira AL, Ouros CC, Chavesk GHC, Souza MLR, de Oliveira Marques D, Claudino-Silva SC.   +16 more
europepmc   +1 more source

Understanding lipidomics associations and the lipoprotein-related caveats in population epidemiology. [PDF]

Am J Epidemiol
Zhao S, Ohukainen P, Kettunen J, Järvelin MR, Kähönen M, Lehtimäki T, Viikari J, Raitakari OT, Mäkinen VP, Ala-Korpela M.   +9 more
europepmc   +1 more source