Results 131 to 140 of about 7,630 (250)

Platelet‐Activating Factor Pathway in Women With Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity

Obesity, Volume 34, Issue 5, Page 1056-1067, May 2026.
Increased hepatic PAFR expression in MASLD is associated with histological disease severity and may contribute to progression through platelet activation, whereas circulating Lp‐PLA2 levels lack discriminatory value as a noninvasive biomarker. ABSTRACT Objective This study aimed to investigate the platelet‐activating factor (PAF) pathway in obesity ...
Joan Duran‐Bertran, Helena Clavero‐Mestres, Razieh Mahmoudian, Sara Muñiz‐Piera, Carmen Aguilar, David Riesco, Javier Camaron, Salomé Martínez, Margarida Vives, Marta París, Fàtima Sabench, Teresa Auguet   +11 more
wiley   +1 more source

Reduction in Synaptic Vesicle Protein Abundance but Increased Amounts of Nsg2 and Lpcat1 in Cerebral Cortices Without the Endosomal SNARE Proteins Vti1a and Vti1b

PROTEOMICS, Volume 26, Issue 5, Page 86-97, May 2026.
ABSTRACT Absence of the endosomal SNAREs vti1a and vti1b results in perinatal death and severe neuronal phenotypes in mice, while lack of one of these proteins results in minor phenotypes. Proteomic differences were investigated to obtain a deeper insight into processes in which vti1a and vti1b are involved.
Julia Gottschalk, Katharina Kotschnew, Julia Hahn, Thomas Patschkowski, Gabriele von Fischer von Mollard   +4 more
wiley   +1 more source

Nettle supplementation improves antioxidant status and modulates inflammatory response by altering lysophosphatidylcholines and enterolactone metabolism in dairy cows

Animal Nutrition
Nettle is not only a nutrient-rich forage but also possesses the potential to act as a nutritional and physiological regulator. This study investigated the effects of supplementing nettle hay into the total mixed rations (TMR) on milk yield, milk ...
Qian Zhang, Na Ta, Jize Zhang, Xiaozhen Liu, He Ding, Xiaoqing Zhang   +5 more
doaj   +1 more source

Citrate‐Dependent Activation of Acetyl CoA Carboxylase Promotes Renal Lipid Accumulation in a Rat Model of Chronic Kidney Disease

Acta Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Background Abnormal accumulation of lipids within the kidney contributes to the progression of chronic kidney disease, but the underlying metabolic mechanisms remain unclear. Citrate is a central metabolite in cellular energy regulation and is frequently elevated in advanced kidney disease, yet its impact on renal lipid metabolism has not been
Marta Sanz‐Gómez, Beatriz Linillos‐Pradillo, Rubén Fernández de la Rosa, Isabel Aránguez, Reinhold Kreutz, Antonia García, Coral Barbas, Adrián Plaza, María S. Fernández‐Alfonso   +8 more
wiley   +1 more source

Quantification and Localisation of New Brain Lipid Synthesis Using Deuterium Oxide and High Resolution Mass Spectrometry

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Liquid chromatography tandem mass spectrometry and mass spectrometry imaging were used in combination with deuterium oxide administration to quantify and localise newly synthesised myelin lipids in the mouse brain. This methodology, used here to show sites of myelin repair, enables the measurement of dynamic lipid synthesis in living systems and ...
Catherine Zhang, Jesse A. Michael, Jonathan D. Teo, Huitong Song, Mika T. Westerhausen, Shadrack M. Mutuku, Shane R. Ellis, Anthony S. Don   +7 more
wiley   +2 more sources

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, Volume 183, Issue 9, Page 1939-1957, May 2026.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

HPLC-MS-Based Metabonomics Reveals Disordered Lipid Metabolism in Patients with Metabolic Syndrome

Journal of Analytical Science and Technology, 2011
Ultra-high performance liquid chromatography/ quadrupole time of flight mass spectrometry-based metabonomics platform was employed to profile the plasma metabolites of patients with metabolic syndrome and the healthy controls. Data analysis revealed lots
Xinjie Zhao, Yan Chu, Shili Chen, Peng Gao, Li Zhang, Libin Zhan, Guowang Xu   +6 more
doaj  

Serum Metabolomics Study Reveals a Diagnostic Model for Lung Cancer Brain Metastasis

The Clinical Respiratory Journal, Volume 20, Issue 5, May 2026.
The overall workflow of noninvasive and efficient early diagnostic methods and key features of metabolic dysregulation associated with lung cancer brain metastasis, providing novel molecular insights into its pathogenesis and laying a foundation for future translational applications.
Hongxia Zhu, Yinuo Jin, Xin You, Qi Wang
wiley   +1 more source

High-fat diet feeding differentially affects the development of inflammation in the central nervous system [PDF]

, 2016

core   +1 more source