Results 241 to 250 of about 180,932 (288)
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Intracellular trafficking of lysosomal proteins and lysosomes
Int. Journal of Clinical Pharmacology and Therapeutics, 2009In the synthesis and trafficking of precursors of most lysosomal matrix proteins, the stages necessary for lysosomal delivery include the addition of phosphorylated mannose-rich oligosaccharides, binding of the modified proteins to receptors, their segregation from the secretory pathways and delivery to the endosomal pathway.
A, Hasilik, C, Wrocklage, B, Schröder
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Lysosomes and lysosomal cathepsins in cell death
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2012Lysosomes are the key degradative compartments of the cell. Lysosomal cathepsins, which are enclosed in the lysosomes, help to maintain the homeostasis of the cell's metabolism by participating in the degradation of heterophagic and autophagic material. Following the targeted lysosomal membrane's destabilization, the cathepsins can be released into the
Repnik, Urška +3 more
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Lysosomes, Lysosomal Enzymes, and Cancer
1992Publisher Summary Lysosomes are membrane-enclosed cytoplasmic organelles, which posses an acidic interior that contains many hydrolytic enzymes. Their major function is in the the degradation of macromolecules, which may be cellular or foreign in origin.
M J, Boyer, I F, Tannock
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Lysosomal Biogenesis in Lysosomal Storage Disorders
Experimental Cell Research, 1997Lysosomal biogenesis is an orchestration of the structural and functional elements of the lysosome to form an integrated organelle and involves the synthesis, targeting, functional residence, and turnover of the proteins that comprise the lysosome. We have investigated lysosomal biogenesis during the formation and dissipation of storage vacuoles in two
Karageorgos, L. +6 more
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Ultrastructural Pathology, 1983
Under many circumstances, macrophages accumulate lipids (possibly in combination with other materials) in the form of micelles that by their rigidity and size impart an irregular, angulate shape to the lysosomes in which they are stored. When macrophages contain large numbers of these angulate lysosomes, they have a characteristic light microscopic ...
K P, Dingemans +2 more
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Under many circumstances, macrophages accumulate lipids (possibly in combination with other materials) in the form of micelles that by their rigidity and size impart an irregular, angulate shape to the lysosomes in which they are stored. When macrophages contain large numbers of these angulate lysosomes, they have a characteristic light microscopic ...
K P, Dingemans +2 more
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Lysosomes and Lysosomal Disorders
1989Lysosomes are membranous vesicles that are present in almost all kinds of body cells. Their number varies greatly from one cell to another, depending on its type and function. They have been given their name because they are small bodies (soma = body) containing various enzymes that are hydrolytic (lysis = dissolution).
Marjo S. van der Knaap, Jacob Valk
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Autophagic lysosome reformation
Experimental Cell Research, 2013 Autophagy is an evolutionarily conserved lysosome-dependent degradation pathway. In recent years, many important advances have been made in understanding the cellular and molecular mechanism of autophagosome formation.
Li Yu
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2015
The physiology and functions of ion channels have been major topics of interest in biomedical research. Patch clamping is one of the most powerful techniques used in the study of ion channels and has been widely applied to the investigation of electrical properties of ion channels on the plasma membrane in a variety of cells.
Xi Z, Zhong, Xian-Ping, Dong
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The physiology and functions of ion channels have been major topics of interest in biomedical research. Patch clamping is one of the most powerful techniques used in the study of ion channels and has been widely applied to the investigation of electrical properties of ion channels on the plasma membrane in a variety of cells.
Xi Z, Zhong, Xian-Ping, Dong
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Rethinking lysosomes and lysosomal disease
Neuroscience Letters, 2021Lysosomal storage diseases were recognized and defined over a century ago as a class of disorders affecting mostly children and causing systemic disease often accompanied by major neurological consequences. Since their discovery, research focused on understanding their causes has been an important driver of our ever-expanding knowledge of cell biology ...
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PROTEOMICS, 2010
Abstract Lysosomes are organelles of eukaryotic cells that are critically involved in the degradation of macromolecules mainly delivered by endocytosis and autophagocytosis. Degradation is achieved by more than 60 hydrolases sequestered by a single phospholipid bilayer.
Bernd A, Schröder +3 more
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Abstract Lysosomes are organelles of eukaryotic cells that are critically involved in the degradation of macromolecules mainly delivered by endocytosis and autophagocytosis. Degradation is achieved by more than 60 hydrolases sequestered by a single phospholipid bilayer.
Bernd A, Schröder +3 more
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