Results 1 to 10 of about 82,606 (197)
The role of lysosomes in cancer development and progression
Cell & Bioscience, 2020 Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release,
Tao Tang +9 more
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Neuroscience Letters, 2019 Lysosomes support diverse cellular functions by acting as sites of macromolecule degradation and nutrient recycling. The degradative abilities of lysosomes are conferred by a lumen that is characterized by an acidic pH and which contains numerous ...
S. Ferguson
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Data in Brief, 2023 Automated detection of cell nuclei in fluorescence microscopy images is a key task in bioimage analysis. It is essential for most types of microscopy-based high-throughput drug and genomic screening and is often required in smaller scale experiments as ...
Malou Arvidsson +2 more
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Granular Cell Ameloblastoma: A Rare Case Report and Literature Review [PDF]
Journal of Clinical and Diagnostic Research, 2023 Ameloblastomas are rare, benign, aggressive neoplasms of odontogenic epithelial origin. Among the various types of ameloblastomas, granular cell ameloblastoma is rare and accounts for less than 5% of the total.
Samiha Jameel Ahmed Khan +4 more
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Branching Off: New Insight Into Lysosomes as Tubular Organelles
Frontiers in Cell and Developmental Biology, 2022 Lysosomes are acidic, membrane-bound organelles that play essential roles in cellular quality control, metabolism, and signaling. The lysosomes of a cell are commonly depicted as vesicular organelles.
K. Adam Bohnert, Alyssa E. Johnson
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USP17 is required for peripheral trafficking of lysosomes
EMBO Reports, 2022 Expression of the deubiquitinase USP17 is induced by multiple stimuli, including cytokines (IL‐4/6), chemokines (IL‐8, SDF1), and growth factors (EGF), and several studies indicate it is required for cell proliferation and migration.
Jia Lin +13 more
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Parkinson's disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes.
Cell, 2022 Lysosomes require an acidic lumen between pH 4.5 and 5.0 for effective digestion of macromolecules. This pH optimum is maintained by proton influx produced by the V-ATPase and efflux through an unidentified "H+ leak" pathway. Here we show that TMEM175, a
Meiqin Hu +13 more
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Super‐resolution analyzing spatial organization of lysosomes with an organic fluorescent probe
Exploration, 2022 Lysosomes are multifunctional organelles involved in macromolecule degradation, nutrient sensing, and autophagy. Live imaging has revealed lysosome subpopulations with dynamics and characteristic cellular localization.
Lei Wang +6 more
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The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes
Cell Discovery, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to escape clearance by host cells is unknown.
Yabin Zhang +7 more
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Role of lysosomes in physiological activities, diseases, and therapy
Journal of Hematology & Oncology, 2021 Long known as digestive organelles, lysosomes have now emerged as multifaceted centers responsible for degradation, nutrient sensing, and immunity. Growing evidence also implicates role of lysosome-related mechanisms in pathologic process. In this review,
Ziqi Zhang +5 more
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