Variable-order fractional master equation and clustering of particles: non-uniform lysosome distribution [PDF]
, 2021 In this paper, we formulate the space-dependent variable-order fractional master equation to model clustering of particles, organelles, inside living cells. We find its solution in the long time limit describing non-uniform distribution due to a space dependent fractional exponent.
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Homozygous GRN mutations: unexpected phenotypes and new insights into pathological and molecular mechanisms [PDF]
Brain - A Journal of Neurology , Oxford University Press (OUP),
2020, 143 (1), pp.303-319, 2020 Homozygous mutations in the progranulin gene (GRN) are associated with neuronal ceroid lipofuscinosis 11 (CLN11), a rare lysosomal-storage disorder characterized by cerebellar ataxia, seizures, retinitis pigmentosa, and cognitive disorders, usually beginning between 13 and 25 years of age.
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Asymptotic behavior of the solution of the space dependent variable order fractional diffusion equation: ultra-slow anomalous aggregation [PDF]
Phys. Rev. Lett. 123, 050602 (2019), 2019 We find for the first time the asymptotic representation of the solution to the space dependent variable order fractional diffusion and Fokker-Planck equations. We identify a new advection term that causes ultra-slow spatial aggregation of subdiffusive particles due to dominance over the standard advection and diffusion terms, in the long-time limit ...
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Interactions between Magnetic Nanowires and Living Cells : Uptake, Toxicity and Degradation [PDF]
ACS Nano, 2011, 5 (7), pp 5354--5364, 2011 We report on the uptake, toxicity and degradation of magnetic nanowires by NIH/3T3 mouse fibroblasts. Magnetic nanowires of diameters 200 nm and lengths comprised between 1 {\mu}m and 40 {\mu}m are fabricated by controlled assembly of iron oxide ({\gamma}-Fe2O3) nanoparticles.
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Radiosensitization beyond DNA damage: Monte Carlo simulations of realistic nanomaterial biodistributions [PDF]
arXiv, 2023 We investigated cellular distribution of a tumor-specific gadolinium chelate in 4T1 and U87 cancer cells with the goal to generate more realistic geometries for Monte Carlo simulations of radiation interaction with nanoparticles in cells. Cells were exposed to the agent in-vitro for 30 minutes to 72 hours before being fixed and imaged using ...
arxiv
The riddle of the plant vacuolar sorting receptors [PDF]
Protoplasma 226 (12/2005) 103-8, 2006 Proteins synthesized on membrane-bound ribosomes are sorted at the Golgi apparatus level for delivery to various cellular destinations: the plasma membrane or the extracellular space, and the lytic vacuole or lysosome. Sorting involves the assembly of vesicles, which preferentially package soluble proteins with a common destination.
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Cytoplasmic nanojunctions between lysosomes and sarcoplasmic reticulum are required for specific calcium signaling [PDF]
, 2014 We demonstrate how nanojunctions between lysosomes and sarcoplasmic reticulum (L-SR junctions) serve to couple lysosomal activation to regenerative, ryanodine receptor-mediated cellular calcium (Ca2+) waves. In pulmonary artery smooth muscle cells (PASMCs) nicotinic acid adenine dinucleotide phosphate (NAADP) may trigger increases in cytoplasmic Ca2 ...
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Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells [PDF]
CPT: Pharmacometrics & Systems Pharmacology 4, no. 4 (2015):
263-272, 2013 Autophagy is a conserved biological stress response in mammalian cells that is responsible for clearing damaged proteins and organelles from the cytoplasm and recycling their contents via the lysosomal pathway. In cases of mild stress, autophagy acts as a survival mechanism, while in cases of severe stress cells may switch to programmed cell death ...
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Magnetic hyperthermia properties of nanoparticles inside lysosomes using kinetic Monte-Carlo simulations : influence of key parameters, of dipolar interactions and spatial variation of heating power [PDF]
, 2014 Understanding the influence of dipolar interactions in magnetic hyperthermia (MH) experiments is of crucial importance for a fine optimization of nanoparticle (NP) heating power. In this study, we use a kinetic Monte-Carlo algorithm to calculate hysteresis loops, so both time and temperature are correctly taken into account.
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Graphene oxide upregulates the homeostatic functions of primary astrocytes and modulates astrocyte-to-neuron communication [PDF]
Nano Lett. 2018, 18, 9, 5827-5838, 2018 Graphene-based materials are the focus of intense research efforts to devise novel theranostic strategies for targeting the central nervous system. In this work, we have investigated the consequences of long-term exposure of primary rat astrocytes to pristine graphene (GR) and graphene oxide (GO) flakes.
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