Results 231 to 240 of about 239,873 (360)

Detection and quantitation of ferritinophagy using HaloTag tracing. [PDF]

J Biol Chem
Kempelingaiah SK, Straus AJ, Mavodza G, Senkal CE.   +3 more
europepmc   +1 more source

The Fab1/PIKfyve Phosphoinositide Phosphate Kinase Is Not Necessary to Maintain the pH of Lysosomes and of the Yeast Vacuole [PDF]

, 2015
Cheuk Y. Ho, Christopher H. Choy, Christina A. Wattson, Danielle Johnson, Roberto J. Botelho   +4 more
openalex   +1 more source

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Dictyostelium discoideum flotillin homologues are essential for phagocytosis and participate in plasma membrane recycling and lysosome biogenesis [PDF]

, 2019
Cristina Bosmani, Frauke Bach, Florence Leuba, Nabil Hanna, Frédéric Burdet, Marco Pagni, Monica Hagedorn, Thierry Soldati   +7 more
openalex   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

NoxO1 promotes endosome formation and reduces intracellular vesicle processing. [PDF]

Redox Biol
Hebchen M, Herwig F, Schader T, Spaeth M, Müller N, Schröder K.   +5 more
europepmc   +1 more source

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

Aggregation-induced emission of DNA fluorescence as a novel pan-marker of cell death, senescence and sepsis <i>in vitro</i> and <i>in vivo</i>. [PDF]

Theranostics
Hu Y, Wang X, Lu K, Cheang C, Liu Y, Zhu Y, Xie L, Li M, Zhou Q, Yan W, Hou Y, Zhang H, Zheng W, Xu C, Chen X, Shen HM, Huang ZJ, Chen YH, Zhou Y, Cai PL, Zhong H, Liu L, Wu XP, Liu X, Li X, Zeng N, Assaraf YG, Liu TM.   +27 more
europepmc   +1 more source

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway [version 1; referees: 2 approved, 2 approved with reservations] [PDF]

, 2016
et al,, Ory, Daniel S
core   +1 more source

The discovery of PCSK9 inhibitors: A tale of creativity and multifaceted translational research. [PDF]

, 2013
Elguindy, A, Yacoub, MH
core   +1 more source