Results 231 to 240 of about 228,048 (263)

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding, Yingjie Zhang, Li Zhang, Xinou Zheng, Miaomiao Niu, Yunxiao Jia, Xuezhuang Li, Hua Chen, Chao Guo, Tao Jiang, Yuqiong Zhao   +10 more
wiley   +1 more source

Control of microglial dynamics by the Arp2/3 complex and the autism- and schizophrenia-associated protein CYFIP1. [PDF]

Proc Natl Acad Sci U S A
Scott-Solache J, Pei J, Drew J, López-Doménech G, Jolivet RB, Nieto-Rostro M, Davenport EC, Arancibia-Cárcamo IL, Attwell D, Kittler JT.   +9 more
europepmc   +1 more source

Small vesicles, big potential: A review of innovative exosome delivery and molecular mechanisms in preclinical myocardial infarction models

Animal Models and Experimental Medicine, EarlyView.
This narrative review discusses animal models of exosome‐based myocardial infarction treatments. Emerging techniques aim to improve exosome stability, targeting, and bioavailability for MI treatment as drug delivery vehicles and regenerative mediators that promote myocardial regeneration. Abstract Exosomes have emerged as promising therapeutic carriers,
Chayanisa Phutiyothin, Kovit Pattanapanyasat, Sarawut Kumphune   +2 more
wiley   +1 more source

Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity. [PDF]

Cell Res
Li Y, Zheng M, Zhu Z, Zhang Y, Ning P, Chen H, Gao R, Xu C, Wei X, Liu Y, Wang Y, Zhou R, Li Y, Li Z, Lv C, Liu C, Xu J, Guo Z, Hu Z, Fang L, Wei K, Feng M, Zhou C, She Y, Sun W, Chen E, Plaza GR, He B, Miska J, Yang W, Tang Y, Liu H, Chen C, Cheng Y.   +33 more
europepmc   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

A novel SO2 probe inhibits lysophagy induced by Senecavirus A infection by promoting LAMP1 Cys375 sulfenylation. [PDF]

PLoS Pathog
Wang S, Han W, Zhao B, Hong Y, Li J, Miao J, Lin Z.   +6 more
europepmc   +1 more source

Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function. [PDF]

Cell Death Dis
Qin Y, Teker SS, La Cunza N, Tong Y, Theusch E, Yang NV, Venkatesan L, Su J, Wang X, Krauss RM, Lakkaraju A, Mattis AN, Medina MW.   +12 more
europepmc   +1 more source

Decoding Drug Resistance in Pancreatic Cancer: A Subcellular Structure Perspective. [PDF]

Biology (Basel)
Li X, Lyu H, Wu Y, Chen A, Wu G, Zhang R, Xiao S, Guo D, Zhang Q, Yan C, Tang J, Zhou C.   +11 more
europepmc   +1 more source

Lysosome heterogeneity and diversity mapped through its distinct cellular functions. [PDF]

Cell Mol Life Sci
Chavan I, Bhattacharjee A.
europepmc   +1 more source