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Rethinking lysosomes and lysosomal disease
Neuroscience Letters, 2021Lysosomal storage diseases were recognized and defined over a century ago as a class of disorders affecting mostly children and causing systemic disease often accompanied by major neurological consequences. Since their discovery, research focused on understanding their causes has been an important driver of our ever-expanding knowledge of cell biology ...
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PROTEOMICS, 2010
Abstract Lysosomes are organelles of eukaryotic cells that are critically involved in the degradation of macromolecules mainly delivered by endocytosis and autophagocytosis. Degradation is achieved by more than 60 hydrolases sequestered by a single phospholipid bilayer.
Bernd A, Schröder +3 more
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Abstract Lysosomes are organelles of eukaryotic cells that are critically involved in the degradation of macromolecules mainly delivered by endocytosis and autophagocytosis. Degradation is achieved by more than 60 hydrolases sequestered by a single phospholipid bilayer.
Bernd A, Schröder +3 more
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The Cytoplasm: Lysosomes and Lysosomal Disorders
2015Lysosomes are enriched in hydrolytic enzymes working at low pH, which include proteases, lipases, glycosidases, nucleases, phosphatases, and sulfatases, and are responsible for elimination of “unwanted” molecules derived from both the cell itself (autophagy, cf. Fig. 74) or from outside of the cells (heterophagy). However, contrary to the historic view
Margit Pavelka, Jürgen Roth
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Acta Histochemica, 1987
A characteristic of lysosomal cysteine proteinases is given by their kinetic constants with specific substrates, their sequence homology, and their reactivity with monospecific polyclonal antibodies.
H, Kirschke, B, Wiederanders
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A characteristic of lysosomal cysteine proteinases is given by their kinetic constants with specific substrates, their sequence homology, and their reactivity with monospecific polyclonal antibodies.
H, Kirschke, B, Wiederanders
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1967
Publisher Summary This chapter focuses on the histochemistry of lysosomes. Lysosomes are defined originally as a biochemical entity. Consequently, the biochemical criteria form a basis for the histochemical identification of these particles. Ideally, the prime criteria which appear necessary for the demonstration of a lysosome are (1) the presence of
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Publisher Summary This chapter focuses on the histochemistry of lysosomes. Lysosomes are defined originally as a biochemical entity. Consequently, the biochemical criteria form a basis for the histochemical identification of these particles. Ideally, the prime criteria which appear necessary for the demonstration of a lysosome are (1) the presence of
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Annual Review of Cell Biology, 1989
Article de synthese sur les lysosomes: biogenese, definition, role biologique. Les enzymes lysosomales sont decrites ainsi que leur role dans l'exo et l'endocytose.
S, Kornfeld, I, Mellman
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Article de synthese sur les lysosomes: biogenese, definition, role biologique. Les enzymes lysosomales sont decrites ainsi que leur role dans l'exo et l'endocytose.
S, Kornfeld, I, Mellman
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Paediatrics and Child Health, 2002
Although most lysosomal storage disorders present in infancy or early childhood with a progressive condition often associated with dysmorphism, considerable genetic heterogeneity exists resulting in a range of illnesses that can include a dramatic neonatal presentation.
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Although most lysosomal storage disorders present in infancy or early childhood with a progressive condition often associated with dysmorphism, considerable genetic heterogeneity exists resulting in a range of illnesses that can include a dramatic neonatal presentation.
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Nature, 1966
IN recent years there has been much interest in the role of crystals in causing acute attacks of gout. Faires and his colleagues at Philadelphia1 and Seegmiller et al. at Bethesda2 were able to produce such attacks by injecting microcrystalline sodium monourate into gouty and non-gouty volunteers.
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IN recent years there has been much interest in the role of crystals in causing acute attacks of gout. Faires and his colleagues at Philadelphia1 and Seegmiller et al. at Bethesda2 were able to produce such attacks by injecting microcrystalline sodium monourate into gouty and non-gouty volunteers.
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Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Nature Reviews Molecular Cell Biology, 2023Carmine Settembre, Rushika Perera
exaly
1979
Steroids in general and glucocorticoids in particular affect lysosomes in various ways. The explanation of these effects remains in dispute, however. Theories include the view that steroids interact directly with lysosomal membranes, that steroids provoke induced changes in lysosomes, and that classical steroid receptors originate in lysosomes ...
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Steroids in general and glucocorticoids in particular affect lysosomes in various ways. The explanation of these effects remains in dispute, however. Theories include the view that steroids interact directly with lysosomal membranes, that steroids provoke induced changes in lysosomes, and that classical steroid receptors originate in lysosomes ...
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