Results 21 to 30 of about 239,873 (360)
The trafficking and targeting of P2X receptors [PDF]
, 2013 The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very ...
Murrell-Lagnado, Ruth D +1 more
core +3 more sources
Neuroscience Letters, 2019 Lysosomes support diverse cellular functions by acting as sites of macromolecule degradation and nutrient recycling. The degradative abilities of lysosomes are conferred by a lumen that is characterized by an acidic pH and which contains numerous hydrolases that support the breakdown of major cellular macromolecules to yield cellular building blocks ...
openaire +2 more sources
Annual Review of Physiology, 2015 Lysosomes are acidic compartments filled with more than 60 different types of hydrolases. They mediate the degradation of extracellular particles from endocytosis and of intracellular components from autophagy. The digested products are transported out of the lysosome via specific catabolite exporters or via vesicular membrane trafficking.
Haoxing, Xu, Dejian, Ren
openaire +2 more sources
Lysosomes: multifunctional compartments ruled by a complex regulatory network
FEBS Open Bio, 2022 More than 50 years have passed since Nobel laureate Cristian de Duve described for the first time the presence of tiny subcellular compartments filled with hydrolytic enzymes: the lysosome.
Jonathan Martinez‐Fabregas +2 more
doaj +1 more source
Pharmaceutics, 2021 Cyclodextrins are widely used excipients for increasing water-solubility, delivery and bioavailability of lipophilic drugs. By using fluorescent cyclodextrin derivatives, we showed previously that cyclodextrins are able to enter Caco-2 intestinal cells ...
Ágnes Rusznyák +13 more
doaj +1 more source
Pharmaceuticals, 2021 Ursolic acid (UA) is a bioactive compound which has demonstrated therapeutic efficacy in a variety of cancer cell lines. UA activates various signalling pathways in Glioblastoma multiforme (GBM) and offers a promising starting point in drug discovery ...
Gillian E. Conway +8 more
doaj +1 more source
Cells, 2022 β-glucocerebrosidase is a lysosomal hydrolase involved in the catabolism of the sphingolipid glucosylceramide. Biallelic loss of function mutations in this enzyme are responsible for the onset of Gaucher disease, while monoallelic β-glucocerebrosidase ...
Giulia Lunghi +18 more
doaj +1 more source
Proteomic Analysis of Mucopolysaccharidosis IIIB Mouse Brain
Biomolecules, 2020 Mucopolysaccharidosis IIIB (MPS IIIB) is an inherited metabolic disease due to deficiency of α-N-Acetylglucosaminidase (NAGLU) enzyme with subsequent storage of undegraded heparan sulfate (HS). The main clinical manifestations of the disease are profound
Valeria De Pasquale +9 more
doaj +1 more source
The activation of KSHV lytic cycle blocks autophagy in PEL cells [PDF]
, 2015 This study confirms that autophagy is activated concomitantly with KSHV lytic cycle induction, and that autophagy inhibition by BECN1 knockdown reduces viral lytic gene expression.
CIRONE, Mara +7 more
core +1 more source
Lysosomal Functions in Glia Associated with Neurodegeneration
Biomolecules, 2021 Lysosomes are cellular organelles that contain various acidic digestive enzymes. Despite their small size, they have multiple functions. Lysosomes remove or recycle unnecessary cell parts. They repair damaged cellular membranes by exocytosis.
Conlan Kreher +3 more
doaj +1 more source