Results 21 to 30 of about 82,606 (197)

Heteromerization of Endogenous Mu and Delta Opioid Receptors Induces Ligand-Selective Co-Targeting to Lysosomes

Molecules, 2020
Increasing evidence indicates that native mu and delta opioid receptors can associate to form heteromers in discrete brain neuronal circuits. However, little is known about their signaling and trafficking.
Lyes Derouiche, Florian Pierre, Stéphane Doridot, Stéphane Ory, Dominique Massotte   +4 more
doaj   +1 more source

The Role of Exosomes in Lysosomal Storage Disorders

Biomolecules, 2021
Exosomes, small membrane-bound organelles formed from endosomal membranes, represent a heterogenous source of biological and pathological biomarkers capturing the metabolic status of a cell.
Adenrele M. Gleason, Elizabeth G. Woo, Cindy McKinney, Ellen Sidransky   +3 more
doaj   +1 more source

Lysosome-endosome fusion and lysosome biogenesis [PDF]

Journal of Cell Science, 2000
ABSTRACT Recent data both from cell-free experiments and from cultured cells have shown that lysosomes can fuse directly with late endosomes to form a hybrid organelle. This has a led to a hypothesis that dense core lysosomes are in essence storage granules for acid hydrolases and that, when the former fuse with late endosomes, a hybrid ...
J P, Luzio, B A, Rous, N A, Bright, P R, Pryor, B M, Mullock, R C, Piper   +5 more
openaire   +2 more sources

Lysosomes as a therapeutic target

Nature reviews. Drug discovery, 2019
Lysosomes are membrane-bound organelles with roles in processes involved in degrading and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes encoding lysosomal proteins cause lysosomal storage disorders, in which enzyme
S. Bonam, Fengjuan Wang, S. Muller
semanticscholar   +1 more source

Lysosomal Physiology [PDF]

Annual Review of Physiology, 2015
Lysosomes are acidic compartments filled with more than 60 different types of hydrolases. They mediate the degradation of extracellular particles from endocytosis and of intracellular components from autophagy. The digested products are transported out of the lysosome via specific catabolite exporters or via vesicular membrane trafficking.
Haoxing, Xu, Dejian, Ren
openaire   +2 more sources

CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases

Disease Models & Mechanisms, 2021
Mutations in Valosin Containing Protein (VCP) are associated with several degenerative diseases, including multisystem proteinopathy (MSP-1) and amyotrophic lateral sclerosis.
Jordan M. Wall, Ankita Basu, Elizabeth R. M. Zunica, Olga S. Dubuisson, Kathryn Pergola, Joshua P. Broussard, John P. Kirwan, Christopher L. Axelrod, Alyssa E. Johnson   +8 more
doaj   +1 more source

LRRK2 mediates tubulation and vesicle sorting from lysosomes

Science Advances, 2020
The Parkinson disease kinase LRRK2 translocates to the lysosomal membrane triggering lysosomal sorting through JIP4. Genetic variation around the LRRK2 gene affects risk of both familial and sporadic Parkinson’s disease (PD).
Luis Bonet-Ponce, A. Beilina, Chad D. Williamson, Eric Lindberg, Jillian H. Kluss, S. Sáez-Atienzar, N. Landeck, R. Kumaran, A. Mamais, Christopher K. E. Bleck, Yan Li, M. Cookson   +11 more
semanticscholar   +1 more source

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

Cell, 2019
Summary Long-distance RNA transport enables local protein synthesis at metabolically-active sites distant from the nucleus. This process ensures an appropriate spatial organization of proteins, vital to polarized cells such as neurons. Here, we present a
Ya-Cheng Liao, Michael S. Fernandopulle, Guozhen Wang, Heejun Choi, Ling Hao, Catherine M. Drerup, Rajan Patel, S. Qamar, Jonathon Nixon‐Abell, Yi Shen, William Meadows, M. Vendruscolo, T. Knowles, Matthew P. Nelson, Magdalena A. Czekalska, Greta Musteikyte, Mariam A. Gachechiladze, Christina A. Stephens, H. Pasolli, L. Forrest, P. S. George-Hyslop, P. S. George-Hyslop, J. Lippincott-Schwartz, Michael E. Ward   +23 more
semanticscholar   +1 more source

Is Endothelial Nitric Oxide Synthase a Moonlighting Protein Whose Day Job is Cholesterol Sulfate Synthesis? Implications for Cholesterol Transport, Diabetes and Cardiovascular Disease

Entropy, 2012
Theoretical inferences, based on biophysical, biochemical, and biosemiotic considerations, are related here to the pathogenesis of cardiovascular disease, diabetes, and other degenerative conditions.
Stephanie Seneff, Ann Lauritzen, Robert Davidson, Laurie Lentz-Marino   +3 more
doaj   +1 more source

An annotated high-content fluorescence microscopy dataset with EGFP-Galectin-3-stained cells and manually labelled outlineszenodo

Data in Brief
Many forms of bioimage analysis involve the detection of objects and their outlines. In the context of microscopy-based high-throughput drug and genomic screening and even in smaller scale microscopy experiments, the objects that most often need to be ...
Salma Kazemi Rashed, Malou Arvidsson, Rafsan Ahmed, Sonja Aits   +3 more
doaj   +1 more source