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Cytotoxic and senescence-inducing effects of BLU554 in pancreatic ductal adenocarcinoma: an in vitro study. [PDF]
BMC CancerFujiwara M +8 more
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Advanced multimodal imaging: FLIM, PLIM, and FluoRaman enabled by novel diarylacetylene probes.
AnalystHughes JG +11 more
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Lysosomal Biogenesis in Lysosomal Storage Disorders
Experimental Cell Research, 1997Lysosomal biogenesis is an orchestration of the structural and functional elements of the lysosome to form an integrated organelle and involves the synthesis, targeting, functional residence, and turnover of the proteins that comprise the lysosome. We have investigated lysosomal biogenesis during the formation and dissipation of storage vacuoles in two
Karageorgos, L. +6 more
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Acta Histochemica, 1987
A characteristic of lysosomal cysteine proteinases is given by their kinetic constants with specific substrates, their sequence homology, and their reactivity with monospecific polyclonal antibodies.
H, Kirschke, B, Wiederanders
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A characteristic of lysosomal cysteine proteinases is given by their kinetic constants with specific substrates, their sequence homology, and their reactivity with monospecific polyclonal antibodies.
H, Kirschke, B, Wiederanders
openaire +2 more sources
Lysosomes, Lysosomal Enzymes, and Cancer
1992Publisher Summary Lysosomes are membrane-enclosed cytoplasmic organelles, which posses an acidic interior that contains many hydrolytic enzymes. Their major function is in the the degradation of macromolecules, which may be cellular or foreign in origin.
M J, Boyer, I F, Tannock
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Ultrastructural Pathology, 1983
Under many circumstances, macrophages accumulate lipids (possibly in combination with other materials) in the form of micelles that by their rigidity and size impart an irregular, angulate shape to the lysosomes in which they are stored. When macrophages contain large numbers of these angulate lysosomes, they have a characteristic light microscopic ...
K P, Dingemans +2 more
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Under many circumstances, macrophages accumulate lipids (possibly in combination with other materials) in the form of micelles that by their rigidity and size impart an irregular, angulate shape to the lysosomes in which they are stored. When macrophages contain large numbers of these angulate lysosomes, they have a characteristic light microscopic ...
K P, Dingemans +2 more
openaire +2 more sources
Nature Reviews Molecular Cell Biology, 2002
Regulated secretion of stored secretory products is important in many cell types. In contrast to professional secretory cells, which store their secretory products in specialized secretory granules, some secretory cells store their secretory proteins in a dual-function organelle, called a secretory lysosome.
Emma J, Blott, Gillian M, Griffiths
exaly +3 more sources
Regulated secretion of stored secretory products is important in many cell types. In contrast to professional secretory cells, which store their secretory products in specialized secretory granules, some secretory cells store their secretory proteins in a dual-function organelle, called a secretory lysosome.
Emma J, Blott, Gillian M, Griffiths
exaly +3 more sources