Results 41 to 50 of about 154,993 (197)

Probing the interaction of lysozyme with cardiac glycoside digitoxin: experimental and in silico analyses

Frontiers in Molecular Biosciences, 2023
Digitoxin is a cardiac glycoside used to treat heart failure and heart arrhythmia. However, its therapeutic concentration range is very narrow. High doses of digitoxin are associated with severe side effects; therefore, it is necessary to develop the ...
Mohd Sajid Ali, Hamad A. Al-Lohedan, Rittik Bhati, Jayaraman Muthukumaran   +3 more
doaj   +1 more source

Clinical relevance of serum lysozyme in sarcoidosis with kidney impairment

Immunological Medicine
The clinical significance of serum lysozyme in sarcoidosis remains unclear. This study aimed to evaluate the clinical characteristics and kidney function of sarcoidosis patients with elevated serum lysozyme.
Shunichiro Hanai, Yoshiaki Kobayashi, Kojiro Ikeda, Soichiro Kubota, Nakako Tanaka-Mabuchi, Mayu Yazaki, Makiko Konishi, Kazuya Takahashi, Daiki Nakagomi   +8 more
doaj   +1 more source

Activation of the Extracytoplasmic Function σ Factor σV in Clostridioides difficile Requires Regulated Intramembrane Proteolysis of the Anti-σ Factor RsiV

mSphere, 2022
Clostridioides (Clostridium) difficile is one of the leading causes of nosocomial diarrhea. Lysozyme is a common host defense against many pathogenic bacteria. C.
Anthony G. Pannullo, Craig D. Ellermeier
doaj   +1 more source

Protective properties of lysozyme on β-amyloid pathology: implications for Alzheimer disease

Neurobiology of Disease, 2015
The hallmarks of Alzheimer disease are amyloid-β plaques and neurofibrillary tangles accompanied by signs of neuroinflammation. Lysozyme is a major player in the innate immune system and has recently been shown to prevent the aggregation of amyloid-β1-40
Linda Helmfors, Andrea Boman, Livia Civitelli, Sangeeta Nath, Linnea Sandin, Camilla Janefjord, Heather McCann, Henrik Zetterberg, Kaj Blennow, Glenda Halliday, Ann-Christin Brorsson, Katarina Kågedal   +11 more
doaj   +1 more source

Serum amyloid P component promotes formation of distinct aggregated lysozyme morphologies and reduces toxicity in Drosophila flies expressing F57I lysozyme.

PLoS ONE, 2020
Many conflicting reports about the involvement of serum amyloid P component (SAP) in amyloid diseases have been presented over the years; SAP is known to be a universal component of amyloid aggregates but it has been suggested that it can both induce and
Liza Bergkvist, Daniel R Richards, Ana Bernardo-Gancedo, Janet R Kumita, Peter R Nilsson, Ann-Christin Brorsson   +5 more
doaj   +1 more source

Cytotoxicity of amyloid fibrils derived from hen lysozyme with different properties on SH-SY5Y and cytoprotective effect of prunus mume extracts [PDF]

, 2020
Protein misfolding is associated with formation of amyloid fibrils. Hen egg lysozyme, well-known for its structural properties, has been shown by atomic force microscopy to form needle-shaped amyloid fibrils under acidic conditions with high temperature.
Tomoko UTSUNOMIYA, Yoshiharu OKUNO, Ryohei KONO, Sachiko NOMURA, Hirotoshi UTSUNOMIYA   +4 more
core   +1 more source

Oral administration of lysozyme protects against injury of ileum via modulating gut microbiota dysbiosis after severe traumatic brain injury

Frontiers in Cellular and Infection Microbiology
ObjectiveThe current study sought to clarify the role of lysozyme-regulated gut microbiota and explored the potential therapeutic effects of lysozyme on ileum injury induced by severe traumatic brain injury (sTBI) and bacterial pneumonia in vivo and in ...
Weijian Yang, Weijian Yang, Weijian Yang, Weijian Yang, Weijian Yang, Caihua Xi, Caihua Xi, Caihua Xi, Caihua Xi, Caihua Xi, Haijun Yao, Haijun Yao, Haijun Yao, Haijun Yao, Haijun Yao, Qiang Yuan, Qiang Yuan, Qiang Yuan, Qiang Yuan, Qiang Yuan, Jun Zhang, Jun Zhang, Jun Zhang, Jun Zhang, Jun Zhang, Qifang Chen, Qifang Chen, Qifang Chen, Qifang Chen, Qifang Chen, Gang Wu, Gang Wu, Gang Wu, Gang Wu, Gang Wu, Jin Hu, Jin Hu, Jin Hu, Jin Hu, Jin Hu   +39 more
doaj   +1 more source

A novel hybrid protein composed of superoxide-dismutase-active Cu(II) complex and lysozyme

Scientific Reports, 2023
A novel hybrid protein composed of a superoxide dismutase-active Cu(II) complex (CuST) and lysozyme (CuST@lysozyme) was prepared. The results of the spectroscopic and electrochemical analyses confirmed that CuST binds to lysozyme.
Tetsundo Furuya, Daisuke Nakane, Kenichi Kitanishi, Natsuki Katsuumi, Arshak Tsaturyan, Igor N. Shcherbakov, Masaki Unno, Takashiro Akitsu   +7 more
doaj   +1 more source

Lysozyme Modification Using Proteolytic Enzymes

Molecules, 2023
The lysozyme in the chicken egg white consists of various bioactive amino acids. However, these compounds are inactive when they are in the sequence of parent proteins. They become active only when isolated from these proteins.
Łukasz Tomczyk, Grzegorz Leśnierowski, Renata Cegielska-Radziejewska   +2 more
doaj   +1 more source

Lysozyme Inhibitors as Tools for Lysozyme Profiling: Identification and Antibacterial Function of Lysozymes in the Hemolymph of the Blue Mussel

Molecules, 2023
Lysozymes are universal components of the innate immune system of animals that kill bacteria by hydrolyzing their main cell wall polymer, peptidoglycan.
Lise Vanderkelen, Joris M. Van Herreweghe, Chris W. Michiels   +2 more
doaj   +1 more source