Results 141 to 150 of about 152,902 (307)

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression.

PLoS Pathogens
Viral infection leads to heterogeneous cellular outcomes ranging from refractory to abortive and fully productive states. Single cell transcriptomics enables a high resolution view of these distinct post-infection states.
Elliott D SoRelle, Lauren E Haynes, Katherine A Willard, Beth Chang, James Ch'ng, Heather Christofk, Micah A Luftig   +6 more
doaj   +1 more source

Kaposiform hemangioendothelioma: Diagnosis and treatment

Pediatric Investigation, EarlyView.
Vascular endothelial growth factor‐C (VEGF‐C)/vascular endothelial growth factor receptor‐3 (VEGFR‐3) and angiopoietin‐2 (Ang‐2)/tyrosine kinase with immunoglobulin‐like and EGF‐like domain 2 (TIE2) signaling pathways play an important role in lymphangiogenesis.
Yi Tian, Yuanyuan Tian, Li Wei, Zigang Xu, Li Li, Lin Ma   +5 more
wiley   +1 more source

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

A synergistic alliance between nematophagous fungi and organic matter against plant‐parasitic nematodes: a systematic review

Pest Management Science, EarlyView.
Certain beneficial fungi are widely used to control harmful nematodes in crops, especially when combined with organic matter. Together, they improve soil health, support plant growth, and enhance nutrient cycling. This natural partnership offers a promising, environmentally friendly approach to strengthening sustainable agriculture and reducing ...
Ndivhuwo Ramatsitsi, Alen Manyevere, Admire Rukudzo Dzvene   +2 more
wiley   +1 more source

Isolation and Characterization of Novel Lytic Bacteriophages Infecting Carbapenem-Resistant Pathogenic Diarrheagenic and Uropathogenic Escherichia Coli

Kenneth Ssekatawa,1,2 Ibrahim Ntulume,3 Denis Karuhize Byarugaba,3 Slawomir Michniewski,4 Eleanor Jameson,5 Eddie M Wampande,6 Jesca Nakavuma3 1Department of Science Technical and Vocational Education, Makerere University, Kampala, Uganda; 2Africa Center
Ssekatawa K, Ntulume I, Byarugaba DK, Wampande EM, Michniewski S, Jameson E, Nakavuma J   +6 more
core  

Studies on marine bacteria producing lytic enzymes - XI : Effect of pressure treatment on the lytic and autolytic activities [PDF]

, 1985
application/pdfThe effect of the pressure treatment on lytic activity against Micrococcus luteus and autholytic activity was investigated using strain V 37 capable of producing lytic enzyme(s).
Sugahara, Isao, Berger, Leslie Ralph
core  

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

[Lytic antibodies in antibacterial sera. IV. Lytic activity of H-antibodies].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1975
The authors studied the lytic and agglutinating activity of H-antibodies against S. typhimurium. Sera containing H-antibodies proved to possess a distinct lytic activity expressed in the presence of a complement and caused by specific antibodies. In H-antibodies specific lytic activity (as per 1 agglutinating unit) was much weaker than in O-antibodies.
E Z, Rukhadze, V I, Levenson, T M, Andreeva   +2 more
openaire   +1 more source

Clinical Features and Outcomes of Chronic Otitis Media Complications: A 20‐Year Retrospective Study at a Tertiary Hospital

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Chronic otitis media (COM) is a major public health concern, particularly in developing countries. Although complications have decreased with modern antibiotics, they still cause significant morbidity and mortality. This study analyzed the clinical features, bacteriological profiles, and treatment outcomes of COM complications at a ...
Viraporn Atchariyasathian, Nipit Tangchitnob   +1 more
wiley   +1 more source