Results 131 to 140 of about 152,902 (307)

Non-lytic CD8+ T cells reproducibly drive viral escape but escape is slower than that driven by lytic CD8+ T cells.

, 2013
This was observed both for non-lytic factors that reduce infection and non-lytic factors that reduce production; for the three different probabilities of target cell recognition considered and for all secretion patterns considered.
Roland R. Regoes (121293), Konstantinos Chatzimichalis (485230), Becca Asquith (61803), Simon D. W. Frost (155011), Nafisa-Katrin Seich al Basatena (201133), Frederik Graw (175938)   +5 more
core   +1 more source

Long‐Term Clinical Response After Low‐Dose and Short‐Duration Cemiplimab Therapy in a Patient With Xeroderma Pigmentosum in Nepal

JEADV Clinical Practice, EarlyView.
ABSTRACT Xeroderma pigmentosum (XP), an autosomal recessive condition affecting DNA repair, is associated with a high risk of multiple and aggressive cutaneous squamous cell carcinomas (CSCCs). Because of numerous and/or locally advanced tumors, surgery may be difficult.
Sudip Parajuli, Arnab Panta, Sabina Bhandari, Anne Grange, Florent Grange, Upama Paudel   +5 more
wiley   +1 more source

E2F1 suppresses Epstein-Barr virus lytic reactivation through cellular and viral transcriptional networks.

PLoS Pathogens
Epstein-Barr virus (EBV) establishes life-long persistence infection displaying a biphasic viral life cycle - latent phase and lytic replication. While latent EBV infection is linked to several B- and epithelial cell malignancies, periodic lytic-cycle ...
Joyanta Biswas, Sk Asif Ali, Samaresh Malik, Subhadeep Nag, Piyali Mukherjee, Abhik Saha   +5 more
doaj   +1 more source

Lytic cycle: A defining process in oncolytic virotherapy

, 2013
The viral lytic cycle is an important process in oncolytic virotherapy. Most mathematical models for oncolytic virotherapy do not incorporate this process.
Wang, Yujie, Wei, Junjie, Tian, Jianjun Paul   +2 more
core   +1 more source

Antimicrobial Cyclic Peptidomimetics

Macromolecular Rapid Communications, EarlyView.
Singular macromolecular cationic, amphipathic cyclic peptidomimetics with poly(2‐oxazoline)s‐esque backbone structure that undergo self‐assembly in water to form uniform nanoparticles were developed. The cyclic peptidomimetics, which act on bacterial cell membranes, exhibit hydrophobic‐dependent antimicrobial activity and toxicity.
Hao Luo, Edgar H. H. Wong
wiley   +1 more source

Characterising the adaptive t-cell immune response against Kaposi’s sarcoma-associated herpesvirus

, 2010
Kaposi’s sarcoma-associated herpesvirus (KSHV) is causally related to Kaposi’s sarcoma (KS), the most common malignancy in individuals with untreated HIV/AIDS.
Robey, R.C.
core  

Periarticular lytic lesion in a tibia (g41).

, 2019
Periarticular lytic lesion in a tibia (g41).
Thomas Reitmaier (2620993), Bernd Heinzle (6680948), Christine Cooper (3276291)   +2 more
core   +1 more source

Rapid and quantitative phage susceptibility test by ramanome

mLife, EarlyView.
Abstract Antimicrobial resistance poses an escalating global threat, renewing interest in bacteriophage therapy as a precision alternative to antibiotics. However, clinical translation remains hindered by the lack of rapid and quantitative phage susceptibility testing (PST) platforms capable of evaluating host range, infection potency, and effective ...
Xiao Han, Xiaofu Wan, Yang Zhou, Xiaoting Fu, Xiaoshan Zheng, Bo Gao, Shi Huang, Anle Ge, Jiadong Huang, Hongzhou Lu, Jian Xu   +10 more
wiley   +1 more source

Kaposi's sarcoma herpesvirus latency-associated nuclear antigen broadly regulates viral gene expression and is essential for lytic infection.

PLoS Pathogens
Kaposi's sarcoma herpesvirus (KSHV) is a leading cause of malignancy in AIDS and current therapies are limited. Like all herpesviruses, KSHV infection can be latent or lytic.
Shijun Li, Mengbo Wang, Nicholas Van Sciver, Agnieszka Szymula, Vinayak Sadasivam Tumuluri, Athira George, Akshaya Ramachandran, Komal Raina, Catarina N Costa, Bo Zhao, Majid Kazemian, J Pedro Simas, Kenneth M Kaye   +12 more
doaj   +1 more source

Next‐Generation Paleopathology: Using Commercial AI in Bioarchaeological Diagnosis

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT Artificial intelligence encompasses computational systems capable of performing cognitive functions such as learning, reasoning, and problem‐solving. Within this domain, generative AI and large language models such as ChatGPT, Gemini, and Copilot have shown significant potential in clinical diagnostics.
Jessica Mongillo, Giulia Vescovo, Giulia Manzo, Nicoletta Zedda, Barbara Bramanti   +4 more
wiley   +1 more source