Results 121 to 130 of about 567,812 (303)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Bibliographie commentée sur la BBC – 1922-1995

Cahiers du MIMMOC, 2022
Anne Cousson, Élodie Gallet, Anita Jorge, Jeremy Price   +3 more
doaj   +1 more source

Avaliação de caracteres da floração em clones de camucamuzeiro nas condições de terra firme em Belém - Pará. [PDF]

, 2013
O objetivo deste trabalho foi avaliar caracteres de floração em clones de camucamuzeiro nas condições de terra firme, em Belém, Pará. Foram mensurados três caracteres de floração, ao longo de doze meses, em dez clones instalados em delineamento de blocos
MARQUES, D. N., NASCIMENTO, W. M. O. do, OLIVEIRA, M. do S. P. de   +2 more
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Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Public Discourse of Ethiopian Israelis in the Media

French Journal for Media Research, 2016
Ce document met l'accent sur un certain nombre de cas d'Israéliens éthiopiens, et examine le contexte de la langue utilisée pour les décrire dans les médias.
Kayam Orly
doaj  

Guide sur l'utilisation des médias sociaux [PDF]

, 2012
Guide sur l'utilisation des médias sociaux : version pour les étudiants ; Guide sur l'utilisation des médias sociaux : version pour le ...

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Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Médias et conflits sociaux [PDF]

, 1997
Gingras, Anne-Marie
core   +1 more source

Vida social e trabalho no campo: um estudo sobre a diversidade do espaço rural nos pequenos municípios paranaenses. [PDF]

, 2008
Este trabalho tem por objetivo analisar os espaços rurais, tomando como referência o local de moradia e a ocupação da população nos pequenos municípios do Estado do Paraná.
Brandenburg, Alfio, Cintra, Anael Pinheiro de Ulhôa   +1 more
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