Results 71 to 80 of about 85,736 (178)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Le livre dans les activités de médiation scientifique : évaluation et dimension sociale de la médiation des connaissances

open access: yes
International audienceBased on the LivMed research-action project, "Changing the place of books in scientific mediation: from a documentary tool to a mediation device", this article shows that books remain a relevant resource for scientific mediation ...
Coulbaut-Lazzarini, Amélie   +2 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Interpréter les récits de demande d’asile : une perspective légitimiste et militante du statut de réfugié

open access: yesLien Social et Politiques, 2019
Cet article montre comment les interprètes bénévoles qui oeuvrent en association font exister un modèle associatif particulier proche de la médiation et se constituent en acteurs périphériques dans la mise en oeuvre des politiques de l’asile. Réfugiés ou
Maureen Clappe
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Vers une approche intégrée : politique, science et éthique – le rôle clé de la médiation des connaissances en situation de crise sanitaire

open access: yesCanadian Journal of Bioethics
Dans le contexte de la crise sanitaire de COVID 19, la politisation de la science a été une réponse nécessaire, mais incomplète, aux défis posés. Notre perspective construit sur cette complexité à l’intersection de la science, du politique et de l ...
Sarah Mediouni, Antoine Boudreau LeBlanc
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

La Charte confiance du Centre d'arbitrage et de médiation de Madagascar

open access: yes, 2017
Actes du colloque sur le thème « L'arbitrage international dans l'Océan Indien », Colloque organisé par le Centre d'arbitrage et de médiation de Madagascar en partenariat avec l'université catholique de Madagascar, Antananarivo, Madagascar, 18, 19 et 20 ...
Ramangaharivony, Gérard
core   +1 more source

Arbitraire du langage et traduction: de l'interprétation du texte à la médiation de l'autre

open access: yesLingue Culture Mediazioni, 2015
This article, structured in three parts, intends to highlight the close relationship between the arbitrariness of language and interlingual translation. In the first part, the complex idea of arbitrariness of language is defined.
Alberto Bramati
doaj   +1 more source

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