Results 51 to 60 of about 1,573,587 (265)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The inverse M-matrix problem

Linear Algebra and its Applications, 1977
AbstractOne aspect of the inverse M-matrix problem can be posed as follows. Given a positive n × n matrix A=(aij) which has been scaled to have unit diagonal elements and off-diagonal elements which satisfy 0 < y ⩽ aij ⩽ x < 1, what additional element conditions will guarantee that the inverse of A exists and is an M-matrix?
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Generalized AOR Algorithms for Linear Complementarity Problem

Journal of Algorithms & Computational Technology, 2007
In this paper, we propose a class of generalized accelerated overrelaxation (GAOR) methods, in which one special case reduces to the generalized successive overrelaxation(GSOR) methods, for solving a linear complementarity problem LCP ( M, q ...
Dongjin Yuan, Hui Zhang
doaj   +1 more source

The M-theory S-matrix from ABJM: beyond 11D supergravity

Journal of High Energy Physics, 2018
We show that by studying the flat spacetime limit of the Mellin amplitude associated with the four-point correlation function of scalar operators in the stress tensor multiplet of ABJM theory, one can produce the momentum expansion of the M-theory four ...
Shai M. Chester, Silviu S. Pufu, Xi Yin
doaj   +1 more source

M-matrix asymptotics for Sturm–Liouville problems on graphs

Journal of Computational and Applied Mathematics, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Currie, Sonja, Watson, Bruce A.
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Acceptability of the R21/Matrix-M malaria vaccine alongside existing malaria interventions in the trial context

BMJ Global Health
Background The R21/Matrix-M malaria vaccine has been shown to provide high protective efficacy against malaria in a phase III trial, and has been recommended for use by WHO. The vaccine will soon be deployed at scale in sub-Saharan Africa.
Jayne Webster, Brian Greenwood, Daniel Chandramohan, Alassane Dicko, Issaka Sagara, Djibrilla Issiaka, Adrian VS Hill, Halimatou Diawara, Fatoumata Koita, Seydou Traoré, Jane Grant, Mehreen Datoo, Mala Sylla, Abdrahmane Boncane Dicko   +13 more
doaj   +1 more source

Positive eigenvector of nonlinear eigenvalue problem with a singular M-matrix and Newton-SOR iterative solution

Journal of Inequalities and Applications, 2016
Some sufficient conditions are proposed in this paper such that the nonlinear eigenvalue problem with an irreducible singular M-matrix has a unique positive eigenvector.
Cheng-yi Zhang, Yao-yan Song, Shuanghua Luo   +2 more
doaj   +1 more source