Results 61 to 70 of about 19,797,232 (311)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Gauge Theory and Supergravity Duality in the PP-Wave Background [PDF]

, 2005
We test the matrix theory conjecture in the pp-wave by studying two-body interactions between gravitons and membranes. We compute the one-loop effective potential of matrix theory and compare it to the light cone Lagrangian of linearized supergravity. We
Lee, Hok Kong
core   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

B and T cell responses to pre-erythrocytic R21/Matrix-M and blood-stage RH5.1/Matrix-M malaria vaccines in endemic settings

Frontiers in Immunology
IntroductionThere is great interest in combining the licensed pre-erythrocytic malaria vaccine R21/Matrix-M® and the blood-stage candidate vaccine RH5.1/Matrix-M® to maximise efficacy against Plasmodium falciparum malaria.
Caroline K. Bundi, Caroline K. Bundi, Olivia Muñoz, Elizabeth Kibwana, Duncan Bellamy, Lisa Stockdale, Jordan R. Barrett, Jordan R. Barrett, Kirsty McHugh, Kirsty McHugh, Ivanny Mtaka, Wilmina Kalinga, Domtila Kimani, Lydia Nyamako, Kelvias Keter, Rodney Ogwang, Adrian V. S. Hill, Philip Bejon, Philip Bejon, Mainga Hamaluba, Mainga Hamaluba, Sarah E. Silk, Sarah E. Silk, Angela M. Minassian, Angela M. Minassian, Simon J. Draper, Simon J. Draper, Ally I. Olotu, Melissa C. Kapulu, Melissa C. Kapulu, Katie J. Ewer, Carolyn M. Nielsen, Carolyn M. Nielsen   +32 more
doaj   +1 more source

Generalized AOR Algorithms for Linear Complementarity Problem

Journal of Algorithms & Computational Technology, 2007
In this paper, we propose a class of generalized accelerated overrelaxation (GAOR) methods, in which one special case reduces to the generalized successive overrelaxation(GSOR) methods, for solving a linear complementarity problem LCP ( M, q ...
Dongjin Yuan, Hui Zhang
doaj   +1 more source

The M-theory S-matrix from ABJM: beyond 11D supergravity

Journal of High Energy Physics, 2018
We show that by studying the flat spacetime limit of the Mellin amplitude associated with the four-point correlation function of scalar operators in the stress tensor multiplet of ABJM theory, one can produce the momentum expansion of the M-theory four ...
Shai M. Chester, Silviu S. Pufu, Xi Yin
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Acceptability of the R21/Matrix-M malaria vaccine alongside existing malaria interventions in the trial context

BMJ Global Health
Background The R21/Matrix-M malaria vaccine has been shown to provide high protective efficacy against malaria in a phase III trial, and has been recommended for use by WHO. The vaccine will soon be deployed at scale in sub-Saharan Africa.
Jayne Webster, Brian Greenwood, Daniel Chandramohan, Alassane Dicko, Issaka Sagara, Djibrilla Issiaka, Adrian VS Hill, Halimatou Diawara, Fatoumata Koita, Seydou Traoré, Jane Grant, Mehreen Datoo, Mala Sylla, Abdrahmane Boncane Dicko   +13 more
doaj   +1 more source

Positive eigenvector of nonlinear eigenvalue problem with a singular M-matrix and Newton-SOR iterative solution

Journal of Inequalities and Applications, 2016
Some sufficient conditions are proposed in this paper such that the nonlinear eigenvalue problem with an irreducible singular M-matrix has a unique positive eigenvector.
Cheng-yi Zhang, Yao-yan Song, Shuanghua Luo   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source