Results 61 to 70 of about 1,573,587 (265)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exact lattice bosonization of finite N matrix quantum mechanics and c = 1

Journal of High Energy Physics
We describe a new exact lattice bosonization of matrix quantum mechanics (equivalently of non-relativistic fermions) that is valid for arbitrary rank N of the matrix.
Gautam Mandal, Ajay Mohan
doaj   +1 more source

The Matrix-M™ adjuvant: A critical component of vaccines for the 21st century

Human Vaccines & Immunotherapeutics, 2023
Matrix-M™ adjuvant is a key component of several novel vaccine candidates. The Matrix-M adjuvant consists of two distinct fractions of saponins purified from the Quillaja saponaria Molina tree, combined with cholesterol and phospholipids to form 40-nm ...
Linda Stertman, Anna-Karin E. Palm, Behdad Zarnegar, Berit Carow, Carolina Lunderius Andersson, Sofia E. Magnusson, Cecilia Carnrot, Vivek Shinde, Gale Smith, Gregory Glenn, Louis Fries, Karin Lövgren Bengtsson   +11 more
doaj   +1 more source

Nonnegative alternating circulants leading to M-matrix group inverses

Linear Algebra and its Applications, 1996
Let \(\mathcal C\) denote the set of all irreducible nonnegative alternating circulant matrices, i.e. all matrices \(A= \sum^{n- 1}_{i= 0} \alpha_i P^i\), when \(P\) is an \(n\)th order cyclic permutation matrix, where \(\alpha_i> 0\) and \(\alpha_i= \alpha_j\) for \(i= j\pmod 2\).
Chen, Yonghong, Kirkland, Stephen J., Neumann, Michael   +2 more
openaire   +2 more sources

Geometric aspects of the symmetric inverse M-matrix problem [PDF]

Linear Algebra and its Applications, 2016
We investigate the symmetric inverse M-matrix problem from a geometric perspective. The central question in this geometric context is, which conditions on the k-dimensional facets of an n-simplex S guarantee that S has no obtuse dihedral angles. First we study the properties of an n-simplex S whose k-facets are all nonobtuse, and generalize some ...
Brandts, J., Cihangir, A.
openaire   +5 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization

npj Vaccines
Matrix-M® adjuvant, containing saponins, delivers a potent adjuvant effect and good safety profile. Given that Matrix-M is composed of Matrix-A and Matrix-C particles, comprising different saponin fractions, understanding their distinct roles can provide
Behdad Zarnegar, Berit Carow, Jens Eriksson, Eva Spennare, Pontus Öhlund, Eray Akpinar, Emelie Bringeland, Ingrid Lekberg Osterman, Lena Lundqvist, Johanna Antti, Niklas Handin, Per-Henrik Helgesson, Johan Bankefors, Karin Lövgren Bengtsson, Mikael E. Sellin, Anna-Karin E. Palm, Linda Stertman, Carolina Lunderius Andersson   +17 more
doaj   +1 more source

Matrix Pencil Optimal Iterative Algorithms and Restarted Versions for Linear Matrix Equation and Pseudoinverse

Mathematics
We derive a double-optimal iterative algorithm (DOIA) in an m-degree matrix pencil Krylov subspace to solve a rectangular linear matrix equation. Expressing the iterative solution in a matrix pencil and using two optimization techniques, we determine the
Chein-Shan Liu, Chung-Lun Kuo, Chih-Wen Chang   +2 more
doaj   +1 more source

A faster algorithm for identification of an M-Matrix

ANZIAM Journal, 2005
Summary: \(M\)-matrices are important in the consideration of rates of convergence of iterative methods for solving large systems of equations and are applicable in areas such as input-output systems in economic modelling, queuing theory, and engineering. The usual definition of an \(M\)-matrix has, among other requirements, that it must be nonsingular
Wood, R. J., O'Neill, M. J.
openaire   +3 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source