Results 81 to 90 of about 1,573,587 (265)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Stability of one-step and linear multistep methods - a matrix technique approach
Electronic Journal of Qualitative Theory of Differential Equations, 2016 We investigate the stability of one-step and linear multistep methods from a new direction. Our aim is to modify the long and technical proof which is consequently omitted in almost every textbook and make it user-friendly.
Miklós Emil Mincsovics
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Multiplicative maps on generalized \(n\)-matrix rings
CuboLet \(\mathfrak{R}\) and \(\mathfrak{R}'\) be two associative rings (not necessarily with identity elements). A bijective map \(\varphi\) of \(\mathfrak{R}\) onto \(\mathfrak{R}'\) is called an \textit{\(m\)-multiplicative isomorphism} if {\(\varphi (x_ ...
Aisha Jabeen, Bruno L. M. Ferreira
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Expert Review of VaccinesIntroduction The saponin-based Matrix-M adjuvant induces potent and durable immunity through producing long-lasting memory B-cells and broad-based T-cell immunity, across a variety of vaccine platforms.
Jonathan Fix +9 more
doaj +1 more source
On regular splittings of an M-matrix
Linear Algebra and its Applications, 1989 Some results on regular splittings of M-matrices are proved. The study is motivated by a recent work of \textit{H. Schneider} [ibid. 58, 407-424 (1984; Zbl 0561.65020)]. It is shown, first, that if A is a nonsingular M-matrix and \(A=M-N\) is a regular splitting then this splitting is a graph compatible one, and if A is just an M-matrix but \(A=M-N ...
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source