Results 91 to 100 of about 19,797,232 (311)

Finite Orthogonal M Matrix Polynomials

Symmetry
In this study, we aim to construct a finite set of orthogonal matrix polynomials for the first time, along with their finite orthogonality, matrix differential equation, Rodrigues’ formula, several recurrence relations including three-term relation, forward and backward shift operators, generating functions, integral representation and their relation ...
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Matrix interpretation of multiple orthogonality

, 2010
In this work we give an interpretation of a (s(d + 1) + 1)-term recurrence relation in terms of type II multiple orthogonal polynomials.We rewrite this recurrence relation in matrix form and we obtain a three-term recurrence relation for vector ...
Branquinho, Amílcar, Foulquié Moreno, Ana Pilar, Cotrím, Luís   +2 more
core   +1 more source

Sign determinacy of M-matrix minors

Linear Algebra and its Applications, 1987
Let A be a (singular or non-singular) M-matrix, and let G(A) denote its undirected graph. The main result is that if the longest simple cycle of G(A) has length not exceeding 3 then the sign of any minor of A depends only on G(A) and not on the magnitude of the entries of A.
Johnson, Charles R., Olesky, D.D., Robertson, Brian, van den Driessche, P.   +3 more
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Grewia polysaccharide as a pharmaceutical excipient in matrix tablets [PDF]

, 2011
Matrix-based tablets using different concentrations of grewia gum, and the model drug ibuprofen, were prepared using a wet granulation technique. Similar formulations were also prepared using HPMC, guar gum or ethyl cellulose as the polymer matrix.
Conway, Barbara R, Barbara R. Conway, Nep, Elijah I., Nep, E.I., Conway, Barbara R., Elijah I. Nep   +5 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Fuzzy Approximate Solution of Positive Fully Fuzzy Linear Matrix Equations

Journal of Applied Mathematics, 2013
The fuzzy matrix equations A~⊗X~⊗B~=C~ in which A~, B~, and C~ are m×m, n×n, and m×n nonnegative LR fuzzy numbers matrices, respectively, are investigated.
Xiaobin Guo, Dequan Shang
doaj   +1 more source

M-theoretic matrix models [PDF]

, 2015
Some matrix models admit, on top of the usual 't Hooft expansion, an M-theory-like expansion, i.e. an expansion at large N but where the rest of the parameters are fixed, instead of scaling with N .
Grassi, Alba, Marino Beiras, Marcos
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source