Results 71 to 80 of about 20,132,521 (307)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
2D and M-mode echocardiography
Cardiologia Croatica, 2013 There are several basic requirements for a useful and reliable ultrasound examination. Proper implementation of 2D and M-mode echocardiography is among the most important. These methods represent the beginning of each heart ultrasound examination and their reproducibility is the major quality indicator of every single ultrasound examination.
Alen Ruzic, Tea Zaninovic-Jurjevic
openaire +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2003 Multi-mode systems are characterised by a set of interacting operational modes to support different functionalities and standards. In this paper, we present a co-design methodology for multi-mode embedded systems that produces energy-efficient ...
Al-Hashimi, Bashir M +2 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
AIP Advances, 2020 Solving or mitigating the blackout problem suffered by hypersonic vehicles as they re-enter the atmosphere is essential for the smooth communication of hypersonic vehicles.
Wenqiu Li +3 more
doaj +1 more source
"La mode, un secteur dominé par l’homme"
, 2016 http://www.lemonde.fr/m-mode-business-of-fashion/article/2016/10/11/la-mode-un-secteur-domine-par-l-homme_5011837_4497393 ...
Sophie Kurkdjian
core
TOPS Imaging with TerraSAR-X: Mode Design and Performance Analysis
, 2010 This paper reports about the performed investigations for the implementation of the wide swath TOPS imaging mode with TerraSAR-X. The TOPS mode overcomes the limitations imposed by the ScanSAR mode by steering the antenna along-track during the ...
Steinbrecher, Ulrich +9 more
core +1 more source