Results 71 to 80 of about 996,000 (219)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Localizing punctures in M-theory

Journal of High Energy Physics
We use equivariant localization and holography to study four-dimensional N = 1 $$ \mathcal{N}=1 $$ superconformal field theories arising from M5-branes wrapped on a punctured Riemann surface.
Christopher Couzens, Alice Lüscher, James Sparks   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

M-theory boundaries beyond supersymmetry

Journal of High Energy Physics
The chiral worldvolume theory of an M-theory boundary (the so-called M9 brane) is uniquely determined by supersymmetry and anomaly inflow. In this brief note we investigate whether alternative chiral boundary field contents may be allowed by anomaly ...
Miguel Montero, Luis Zapata
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Effervescent spikes in M-theory

Journal of High Energy Physics
AdS3× S3× S3 solutions warped over a Riemann surface, Σ, are indexed by a parameter, γ, that defines the superconformal algebra, D(2, 1; γ) ⨁ D(2, 1; γ) they preserve.
Iosif Bena, Raphaël Dulac, Dimitrios Toulikas, Nicholas P. Warner   +3 more
doaj   +1 more source

A perfectoid duality between M-theory and F-theory

Nuclear Physics B
We present a non-singular, definition-level formulation of F-theory by replacing the traditional shrinking-fiber limit of M-theory with compactification on a tower-completed circle described using perfectoid geometry and condensed mathematics.
Arshid Shabir, Bobby Eka Gunara, Mir Faizal   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The QCD trace anomaly at strong coupling from M-theory. [PDF]

Eur Phys J C Part Fields, 2020
Misra A, Gale C.
europepmc   +1 more source