Results 71 to 80 of about 29,636 (240)

Pharmacokinetic and pharmacodynamic interaction of enavogliflozin, a sodium‐glucose cotransporter 2 inhibitor, with glimepiride and metformin in healthy participants

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Enavogliflozin, a sodium‐glucose cotransporter 2 inhibitor, is expected to be coadministered with antihyperglycaemic drugs with different mechanisms of action. This study aimed to investigate the pharmacokinetic (PK) and pharmacodynamic (PD) interactions between enavogliflozin, glimepiride and metformin.
Kyungrin Chang   +5 more
wiley   +1 more source

Metagenomic Characterisation of Antibiotic Resistance in Anaerobic Digesters and Their Implications for Environmental Health. [PDF]

open access: yesEnviron Microbiol Rep
Anaerobic digester metagenomes revealed diverse resistance‐associated annotations and antibiotic target loci, highlighting their potential role in environmental AMR surveillance. The findings emphasise the need for cautious interpretation of resistome profiles and further host‐resolved analyses to determine the mobility and clinical relevance of ...
Olasupo OA   +12 more
europepmc   +2 more sources

Description of the 59 failures at 6 months of ART (M6) and their outcomes at 12 months of ART (M12).

open access: yes, 2023
ART: antiretroviral therapy; VL: viral load; LTFU: lost to follow-up *these events occurred before a blood sample for confirmatory VL testing at M6 was collected **this event occurred after the confirmatory VL at M6 was measured but before a blood sample
Mohand Ait-Ahmed (8694450)   +13 more
core   +1 more source

Can Beauty Save the World? A Multimethod Analysis of Regulatory Focus Appeals in Climate Change Advertising

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT This study investigates how organizations can strategically design climate change advertising to foster greater consumer involvement by comparing the effectiveness of promotion‐ and prevention‐focused advertising appeals. Using a sequential explanatory mixed‐methods design, a facial coding experiment revealed that promotion appeals reduced ...
Valentina Mazzoli   +3 more
wiley   +1 more source

Highly Polarized 1,4‐Dihydropyrrolo[3,2‐b]Pyrroles: From Synthesis to Photophysics and Two‐Photon Induced Polymerization

open access: yesChemistry – A European Journal, EarlyView.
Quadrupolar, centrosymmetric 1,4‐dihydropyrrolo[3,2‐b]pyrroles (DHPP) possessing two five‐membered rings and highly polarized architecture are not emissive, but they are good photosensitizers in two‐photon induced polymerization. ABSTRACT A series of ladder‐type, highly polarized functional dyes possessing 1,4‐dihydropyrrolo[3,2‐b]pyrrole (DHPP ...
Krzysztof J. Kochanowski   +7 more
wiley   +1 more source

Blood Eosinophils From CRSwNP Patients Present Higher CCR3 Expression Associated With Olfactory Recovery After Treatment With Dupilumab

open access: yes
International Forum of Allergy &Rhinology, EarlyView.
Emeline Delaunay   +6 more
wiley   +1 more source

The EMA Qualification Opinion for CYP Inhibition‐Mediated Drug–Drug Interaction Predictions: Implications for PBPK Credibility Assessment in the Era of ICH M15

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Clinical pharmacology and pharmacometrics teams are now being encouraged to implement the ICH M15 framework in drug development to support model‐informed decisions in regulatory submissions. Although model performance is an important component of model evaluation, regulatory confidence also depends on the intended context of use (CoU) and the ...
Karen Rowland Yeo   +6 more
wiley   +1 more source

Exploring the Motivation of Employees in a Firm: A Case-Study

open access: yesBusiness Systems Research, 2018
Background: General concept of motivation, which include the motivational techniques and human resources management as a prerequisite for the most important intangible asset is related to the company performance.
Klopotan Igor   +2 more
doaj   +1 more source

Restoration of miR-125b or inhibition of miR-22 impairs in vitro migratory and invasive potential of M12 cells but initially has little effect on cell proliferation.

open access: yes, 2015
(A) A representative growth curve of M12 versus M12+miR-22inhibitor cells is shown. Cells (20,000) were plated in triplicate and viable cells counted at 0, 48, and 72 hours in a Beckman Coulter Vi-CELL automated cell viability analyzer using trypan blue ...
Gene C. Clark (823052)   +8 more
core   +1 more source

A Co‐Designed Implicit‐Reset Path PFD and Current Mismatch Compensated CP Enabling Sub‐0.5% Mismatch and Dead Zone‐Free for Low‐Spur PLLs

open access: yesInternational Journal of Circuit Theory and Applications, EarlyView.
A co‐designed implicit‐reset phase‐frequency detector (PFD) and nonlinear amplifier‐assisted charge pump (CP) achieve dead zone‐free operation from 10 MHz to 4.7 GHz with < 0.5% current mismatch without calibration, enabling −80 dBc of reference spur and 0.50 ps of RMS jitter in a 180 nm of CMOS PLL.
A. Ghaemnia   +3 more
wiley   +1 more source

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