Results 61 to 70 of about 13,887 (165)

Deep Mutational Scanning for the Study and Engineering of Protein Assemblies

Chemistry–Methods, Volume 6, Issue 8, August 2026.
This review explores how deep mutational scanning (DMS) can be used to improve understanding and accelerate engineering of protein assemblies, from natural fibers to engineered nanocages. We discuss various types of protein assemblies and their characterization, provide an introduction to the DMS technique, and then highlight examples in which DMS has ...
Jenna B. Wolfanger, Shoili Banerjee, Carolyn E. Mills   +2 more
wiley   +1 more source

Hybrid Nanomaterial Complexes for Advanced Phage-guided Gene Delivery

Molecular Therapy: Nucleic Acids, 2014
Developing nanomaterials that are effective, safe, and selective for gene transfer applications is challenging. Bacteriophages (phage), viruses that infect bacteria only, have shown promise for targeted gene transfer applications.
Teerapong Yata, Koon-Yang Lee, Tararaj Dharakul, Sirirurg Songsivilai, Alexander Bismarck, Paul J Mintz, Amin Hajitou   +6 more
doaj   +1 more source

Waist‐to‐Body Mass Index Ratio and Risk of Musculoskeletal Disease in Type 2 Diabetes: A Cohort and PhIP‐Seq Analysis

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Musculoskeletal complications in type 2 diabetes (T2DM) are inadequately captured by body mass index (BMI). Waist‐to‐BMI ratio (WBR) may better reflect adverse body composition. We examined cross‐sectional and longitudinal associations between WBR and musculoskeletal disorders in T2DM.
Yongze Zhang, Luxi Lin, Lifeng Zheng, Xiaohuang Lin, Zhaowei Xu, Ximei Shen, Lingning Huang, Fengying Zhao, Sunjie Yan   +8 more
wiley   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, Volume 15, Issue 28, 24 July 2026.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

M13 phage-based antigen presentation and immune response activation in vaccine development for animal infectious diseases

Frontiers in Immunology
Phage display technology has emerged as a versatile platform for vaccine development by integrating antigen presentation with intrinsic immunostimulatory properties.
Guodong Zhou, Guodong Zhou, Jiahui Zhang, Zhihui Zhang, Zhihui Zhang, Shengliang Cao, Shengliang Cao, Yubao Li, Yubao Li, Yubao Li   +9 more
doaj   +1 more source

Identification of two new capsid proteins in bacteriophage M13 [PDF]

FEBS Letters, 1979
MI 3 is a male-specific filamentous coliphage , closely related to the phages fd and fl (reviewed [ 1,2]). The virion is composed of a circular singlestranded DNA (mol. wt 2 X 106) encapsulated in a tubular protein coat of about 850 nm long and 6 nm wide. Up to now it has generally been assumed that the virion coat is composed of two proteins only. The
Simons, Guus F.M., Konings, Ruud N.H., Schoenmakers, John G.G.   +2 more
openaire   +2 more sources

A Decade of Green Nanotechnology: Applications, Advances, and Emerging Directions

Advanced Sustainable Systems, Volume 10, Issue 7, July 2026.
Green nanotechnology offers a pathway to more sustainable nanomaterial design by combining renewable sources, safer synthesis methods, and evidence of performance in practical applications. This review highlights progress over the past decade across environmental remediation, agriculture, energy, and biomedicine, while emphasizing that true ...
Shabnam Manafzadeh, Sree Lekshmi Kishore Kumar, Kari Vinzant, Mariya Khodakovskaya   +3 more
wiley   +1 more source

An Engineered M13 Filamentous Nanoparticle as an Antigen Carrier for a Malignant Melanoma Immunotherapeutic Strategy

Viruses
Bacteriophages, prokaryotic viruses, hold great potential in genetic engineering to open up new avenues for vaccine development. Our study aimed to establish engineered M13 bacteriophages expressing MAGE-A1 tumor peptides as a vaccine for melanoma ...
Nuša Brišar, Katja Šuster, Simona Kranjc Brezar, Robert Vidmar, Marko Fonović, Andrej Cör   +5 more
doaj   +1 more source

High‐Throughput Isolation of Nanomouse‐Derived VHH Domains: A Practical Guide from Immunization to Nanobody Expression

Current Protocols, Volume 6, Issue 7, July 2026.
Abstract Nanobodies are small but specific heavy chain–only antibody fragments. Their small size, relative stability, and ability to access difficult to reach deep‐tissue antigens makes them valuable research, diagnostic, and therapeutic tools. Nanobodies are derived from the variable heavy (VH) domain of heavy chain–only antibodies that are unique to ...
Tessa J. Casselman, Asa W. Huffaker, Kristie C. Mitchell, Jamie E. Schnarrs, Sylvia Ni, Mary E. Skinner, Matthias C. Truttmann   +6 more
wiley   +1 more source

Elucidation of DNA Primase as a Drug Target in Leishmania donovani: Structure‐Guided Inhibitor Identification and Biochemical Validation

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
Structure‐guided and biochemical analyses indicate that DNA primase of Leishmania donovani represents a potential therapeutic target, as repurposed compounds, particularly Pritelivir, demonstrate marked inhibitory effects accompanied by reduced parasite proliferation, replication, and altered cellular morphology in in vitro and cell‐based studies ...
Deep Bhowmik, Anupama Sharma, Ravi Prakash Arya, Diwakar Kumar   +3 more
wiley   +1 more source