Results 81 to 90 of about 23,145 (194)

Crosstalk Between Intratumoral Microbes and Tumor Immunity: Implications for Tumor Therapy

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Emerging studies indicate that microbes are present in tumor cells and immune cells. Intratumoral microbiota (ITM) constitute an important component of the tumor immune microenvironment (TIME) and have an important impact on tumor progression and treatment. Objective Through the general elaboration of ITM represented by bacteria and
Fengxue Li, Lili Qiao, Xinquan Liang, Yingying Zhang, Ning Liang, Jian Xie, Guodong Deng, Yuying Hao, Pingping Hu, Xue Wu, Fangjie Ding, Can Feng, Yiming Mu, Jiandong Zhang   +13 more
wiley   +1 more source

Class of {varphi}X174 Mutants Relatively Deficient in Synthesis of Viral RNA [PDF]

, 1974
Nonpermissive cells infected with {varphi}X174 gene D amber mutants synthesized some sixfold less viral RNA than permissive cells. The decrease was unaffected by increasing the multiplicity of infection and was a consequence of an overall decrease in all
Clements, J. Barklie, Sinsheimer, Robert L.   +1 more
core  

Active Transport of Peptides Across the Intact Human Tympanic Membrane. [PDF]

, 2018
We previously identified peptides that are actively transported across the intact tympanic membrane (TM) of rats with infected middle ears. To assess the possibility that this transport would also occur across the human TM, we first developed and ...
Alexander, Thomas, Bernhardt, Marlen, Harris, Jeffrey P, Husseman, Jacob, Kurabi, Arwa, Nguyen, Quyen, Noack, Volker, Pak, Kwang, Ryan, Allen F, Schaerer, Daniel   +9 more
core   +1 more source

Bacterial Expression of Gene‐Encoding DNA Origami Structures

Small Structures, Volume 7, Issue 2, February 2026.
Bacterial targeting via programmable DNA origami, varying in rigidity and compactness is unexplored. In transformation assays, origami reduces transformation efficiency compared to single‐stranded scaffolds. Structural features and surface modifications, however, improve transformation outcomes.
Verena Dobretzberger, Alexander Hebel, Maria Ponetsmüller, Florian Ohner, Trishant R. Umrekar, Morgan Beeby, Friedrich C. Simmel, Ivan Barišić   +7 more
wiley   +1 more source

A continuous isotropic-nematic liquid crystalline transition of F-actin solutions

, 2002
The phase transition from the isotropic (I) to nematic (N) liquid crystalline suspension of F-actin of average length $3~\mu$m or above was studied by local measurements of optical birefringence and protein concentration. Both parameters were detected to
A. Kerst, A. Suzuki, C. Coppin, F. Gittes, G.L. Vroege, J. Buitenhuis, J. Kas, J.X. Tang, J.X. Tang, Jay X. Tang, Jorge Viamontes, L. Onsager, P.E. Lammert, P.E. Lammert, R. Furukawa, R. Oldenbourg, R.E. Buxbaum, S. Chandrasekhar, S.D. Lee, T. Sato   +19 more
core   +1 more source

Ultra-bright Photoactivatable Fluorophores Created by Reductive Caging [PDF]

, 2014
Sub-diffraction-limit imaging can be achieved by sequential localization of photoactivatable fluorophores, where the image resolution depends on the number of photons detected per localization.
Jia, Shu, Vaughan, Joshua C., Zhuang, Xiaowei   +2 more
core   +1 more source

Crystal structure of Schistosoma mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide‐bound state

Acta Crystallographica Section D, Volume 82, Issue 2, Page 140-150, February 2026.
Structural characterization of S. mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide‐bound state and identifies a schistosome‐specific epitope.Schistosoma mansoni cathepsin D1 (SmCD1) has been shown to be an essential enzyme for helminth metabolism due to its role in haemoglobin degradation: a key amino‐acid ...
Kelly L. Parker, John D. Clarke, Xiaojiao Liu, Barbara F. Gomes, Lauren E.-A. Eyssen, Nicholas Furnham, Floriano Paes Silva-Jr, Raymond J. Owens   +7 more
wiley   +1 more source

An Engineered M13 Filamentous Nanoparticle as an Antigen Carrier for a Malignant Melanoma Immunotherapeutic Strategy

Viruses
Bacteriophages, prokaryotic viruses, hold great potential in genetic engineering to open up new avenues for vaccine development. Our study aimed to establish engineered M13 bacteriophages expressing MAGE-A1 tumor peptides as a vaccine for melanoma ...
Nuša Brišar, Katja Šuster, Simona Kranjc Brezar, Robert Vidmar, Marko Fonović, Andrej Cör   +5 more
doaj   +1 more source

Anti-vaccinia virus effect of M13 bacteriophage DNA

Antiviral Research, 1996
Single-stranded DNA derived from M13 phage was evaluated for antiviral activity in mice infected with vaccinia virus. M13 DNA at a dose as low as 16.7 mg/kg was effective in reducing the number of tail lesions caused by vaccinia virus by more than 90%. A single administration of M13 DNA 1 day before infection was sufficient to reduce significantly the ...
K, Mori, T, Kubo, Y, Kibayashi, T, Ohkuma, A, Kaji   +4 more
openaire   +2 more sources

Probiotic‐Based Materials as Living Therapeutics

Advanced Materials, Volume 38, Issue 1, 2 January 2026.
Recent advances in Engineered Living Materials are highlighted, integrating synthetic biology and advanced materials, with a focus on probiotic‐based therapeutics. Probiotic Living Materials hold great potential for biosensing, infection treatment, osteogenesis, wound healing, vaginal and gastrointestinal disorders, and cancer therapy. breakthroughs in
Laura Sabio, Graham J. Day, Manuel Salmeron‐Sanchez   +2 more
wiley   +1 more source