Results 61 to 70 of about 16,178 (188)

Creative Discretion on the Frontline of Public Services: A Longitudinal Qualitative Digital Diary and Interview Study

Public Administration, EarlyView.
ABSTRACT “Creative discretion”—defined as street‐level bureaucrats' use of their discretion to generate novel and useful ideas for customizing services to meet the needs of service users, superiors, and themselves—is vital as governments shift from traditional public management to a more user‐centered approach, emphasizing responsiveness over ...
Liesbeth Faas, Glenn Houtgraaf, Peter Kruyen, Sandra van Thiel   +3 more
wiley   +1 more source

TKC‐MC: An Effective Strategy for Generating Heritable Heterozygous Mutations in Essential Genes in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT The CRISPR/Cas9 gene‐editing technology has been widely used in defining gene functions and crop improvement. However, some genes are essential for plant growth and development. Loss‐of‐function homozygous mutations in essential genes lead to plant death or sterility.
Meilian Xu, Lang Yan, Min Zhu, Zhitian Zhan, Hong Chen, Dantong Wang, Zhenping Zheng, Yujie Zhang, Lizhong Xiong, Yubing He   +9 more
wiley   +1 more source

On a comparative analysis of internet banking services by the conversion method and the scoring method

Journal of Economics and Management, 2019
Aim/purpose – The main aim of this paper is to analyse and compare implementation of two methods of websites assessment: the conversion method and the scoring method.
Chmielarz Witold, Zborowski Marek
doaj   +1 more source

Assessing D‐Squame as a Minimally Invasive Technique to Evaluate the Cutaneous Immune Response mRNA in a Dog Model of Canine Atopic Dermatitis

Veterinary Dermatology, EarlyView.
ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon, Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Didier Pin   +5 more
wiley   +1 more source

Estimating Full Regional Skeletal Muscle Fibre Orientation from B-Mode Ultrasound Images Using Convolutional, Residual, and Deconvolutional Neural Networks

Journal of Imaging, 2018
This paper presents an investigation into the feasibility of using deep learning methods for developing arbitrary full spatial resolution regression analysis of B-mode ultrasound images of human skeletal muscle.
Ryan Cunningham, María B. Sánchez, Gregory May, Ian Loram   +3 more
doaj   +1 more source

Straight to Phase III: Model‐Informed Approach Speeds Depemokimab Clinical Development in Interleukin‐5‐Driven Diseases

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1005-1015, April 2026.
Straight to Phase III: Model‐informed approach speeds depemokimab clinical development in interleukin‐5‐driven diseases. IL‐5, a key mediator of type 2 inflammation, underlies various diseases, including severe asthma, CRSwNP, EGPA, and HES. Reduction in blood eosinophil count (BEC), a biomarker of IL‐5 activity, is commonly used to evaluate the ...
Chiara Zecchin, Stein Schalkwijk, Isabelle J. Pouliquen, Alienor Berges, Nicholas Bird, Richard Follows, Daren Austin   +6 more
wiley   +1 more source

The Evolving Role of Product Manager - A Systematic Review

Foundations of Management
This systematic review examines the evolving role of product manager (PM), from its inception in the early 20th century to its current state, with a focus on how technological advancements, shifting market dynamics, and evolving company’s strategy have ...
PARIKH Nishant
doaj   +1 more source

Efeitos cardiovasculares e neuroendócrinos do butorfanol e da buprenorfina em cães anestesiados pelo desfluorano Cardiovascular and neuroendocrine effects of butorphanol and buprenorphine in dogs anesthetized with desflurane

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2007
Avaliaram-se os efeitos do butorfanol e da buprenorfina sobre variáveis cardiovasculares e neuroendócrinas em cães anestesiados com desfluorano, utilizando-se 30 cães adultos, machos e fêmeas, distribuídos em três grupos denominados grupo butorfanol (GBT)
A.P. Souza, N. Nunes, P.S.P. Santos, C.T. Nishimori, D.P. Paula, R.M.N. Silva   +5 more
doaj   +1 more source

An IQ Consortium Perspective on the FDA Guidance for Assessment of Pharmacokinetics in Participants With Impaired Renal Function

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 838-845, April 2026.
The FDA published guidance on assessing pharmacokinetics (PK) in participants with impaired renal function in 2024. The IQ CPLG Organ Impairment Working Group summarized the industry’s perspective on this guidance by highlighting a few key updates in the 2024 guidance, including: (1) the recommendation of using estimated glomerular filtration rate ...
Yan Jin, Ashish Sharma, Mariam A. Ahmed, Sravanthi Cheeti, Ying Ou, Damayanthi Devineni, Yizhe Chen, Jitendra S. Kanodia, Yasmeen Abouelhassan, Nadia Noormohamed, Jin Zhou, Patrick Marroum, Vaishali Sahasrabudhe, Islam R. Younis   +13 more
wiley   +1 more source

Stevens’ measurement scales in marketing research – A continuation of discussion on whether researchers can ignore the Likert scale’s limitations as an ordinal scale

Marketing of Scientific and Research Organizations
This article discusses the use of Stevens’ measurement scales in marketing research, contributing to a broader discussion, underway for over 70 years, as to whether researchers can ignore the Likert scale’s limitations as an ordinal scale.
Rutkowski Ireneusz P.
doaj   +1 more source