Results 1 to 10 of about 22,962 (264)

Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs. [PDF]

J Biol Chem, 2016
Although rhodopsin-like G protein-coupled receptors can exist as both monomers and non-covalently associated dimers/oligomers, the steady-state proportion of each form and whether this is regulated by receptor ligands is unknown.
Pediani JD, Ward RJ, Godin AG, Marsango S, Milligan G.   +4 more
europepmc   +3 more sources

The Spinal Muscarinic M1 Receptors and GABAA Receptors Contribute to the McN-A-343–Induced Antinociceptive Effects During Thermal Stimulation of Mice

Journal of Pharmacological Sciences, 2008
The present study was undertaken to clarify how spinal muscarinic receptors are involved in the antinociceptive effects in thermal stimulation. Intrathecal (i.t.) injection of the muscarinic agonist McN-A-343 inhibited the tail-flick response to noxious ...
Kenji Honda, Keigo Horikawa, Suguru Ando, Kohei Koga, Satoshi Kawata, Keisuke Migita, Yukio Takano   +6 more
doaj   +3 more sources

IUPHAR Review on muscarinic M1 and M4 receptors as drug treatment targets relevant to the molecular pathology of schizophrenia

Pharmacological Research
Cobenfy, a co-formulation of xanomeline and trospium, is the first drug not acting on the dopaminergic system of the CNS approved for the treatment of schizophrenia by the FDA.
Brian Dean
doaj   +2 more sources

Effect of Mutated Cu, Zn Superoxide Dismutase (SOD1G93A) on Modulation of Transductional Pathway Mediated by M1 Muscarinic Receptor in SK-N-BE and NSC-34 Cells [PDF]

Frontiers in Physiology, 2018
The constitutive secretion of antioxidant Cu-Zn Superoxide dismutase (SOD1) has been widely demonstrated in many cellular lines. In addition, we showed that as well as the basal SOD1 secretion, this enzyme is also exported through depolarization of ...
Simona Damiano, Anna Sasso, Roberta Accetta, Marcellino Monda, Bruno De Luca, Luigi Michele Pavone, Anna Belfiore, Mariarosaria Santillo, Paolo Mondola   +8 more
doaj   +2 more sources

Maternal consumption of a high-fat diet modulates the inflammatory response in their offspring, mediated by the M1 muscarinic receptor. [PDF]

Front Immunol, 2023
Costa SO, Chaves WF, Lopes PKF, Silva IM, Burguer B, Ignácio-Souza LM, Torsoni AS, Milanski M, Rodrigues HG, Desai M, Ross MG, Torsoni MA.   +11 more
europepmc   +3 more sources

M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera. [PDF]

Sci Rep, 2019
Konar A, Gupta R, Shukla RK, Maloney B, Khanna VK, Wadhwa R, Lahiri DK, Thakur MK.   +7 more
europepmc   +3 more sources

Germacrone alleviates okadaic acid-induced neurotoxicity in PC12 cells via M1 muscarinic receptor-mediated Galphaq (Gq)/phospholipase C beta (PLCβ)/ protein kinase C (PKC) signaling. [PDF]

Bioengineered, 2022
Lin M, Li P, Liu W, Niu T, Huang L.
europepmc   +3 more sources

Mechanisms of Pilocarpine‐Induced Nitric Oxide and Prostaglandin Production in Porcine Ciliary Muscle [PDF]

FASEB BioAdvances
Pilocarpine, a muscarinic receptor agonist, is clinically used to reduce intraocular pressure via ciliary muscle contraction. However, the intracellular signaling pathways mediating pilocarpine‐induced nitric oxide (NO) and prostaglandin E2 (PGE2 ...
Giovanna Benozzi, Emmanuel Quinteros Villarruel, Andrés F. Zuluaga, Betina Orman   +3 more
doaj   +2 more sources

The muscarinic M1 receptor modulates associative learning and memory in psychotic disorders

NeuroImage: Clinical, 2020
Background: Psychotic disorders are characterized by prominent deficits in associative learning and memory for which there are currently no effective treatments.
Geor Bakker, Claudia Vingerhoets, Oswald J.N. Bloemen, Barbara J. Sahakian, Jan Booij, Matthan W.A. Caan, Thérèse A.M.J. van Amelsvoort   +6 more
doaj   +2 more sources

Xanomeline/trospium-induced polyuria: A patient case report [PDF]

Mental Health Clinician
Xanomeline/trospium is a newly approved agent for the management of schizophrenia. Unlike traditional antipsychotics, which are D2 receptor antagonists, xanomeline is an M1/M4 muscarinic acetylcholine receptor agonist coformulated with trospium, a ...
Henry Leach, PharmD, BCPP, Francesca DiGuglielmo, PharmD   +1 more
doaj   +2 more sources