Results 91 to 100 of about 22,962 (264)

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, Volume 46, Issue 1, Page 179-197, January 2026.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

Assessment of Muscarinic Receptor Subtypes in Human and Rat Lower Urinary Tract by Tissue Segment Binding Assay

Journal of Pharmacological Sciences, 2008
Muscarinic receptors in the human and rat lower urinary tract (urinary bladder detrusor muscle and mucosa, and prostate) were identified by intact tissue segment binding assays with two radioligands, and the effects of prolonged receptor activation in ...
Abu Syed Md Anisuzzaman, Shigeru Morishima, Fumiko Suzuki, Takashi Tanaka, Hatsumi Yoshiki, Zakia Sultana Sathi, Hironobu Akino, Osamu Yokoyama, Ikunobu Muramatsu   +8 more
doaj   +1 more source

Changes in adrenergic and cholinergic receptors on human cerebral vessels. Implications for new therapeutic strategies in Alzheimer's Disease [PDF]

Alzheimers Dement
Abstract Background Sporadic cerebral amyloid angiopathy (CAA) occurs as a result of a failure of Intramural Periarterial Drainage (IPAD) of amyloid‐beta (Aβ) along the walls of capillaries and arteries. The motive force for IPAD is provided by the spontaneous contractions of cerebrovascular smooth muscle cells (CVSMC that receive adrenergic and ...
Carare R.
europepmc   +2 more sources

The varieties of the psychedelic experience: A preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines [PDF]

, 2018
Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of
Erowid, Earth, Erowid, Fire, Martínez Vivot, Rocío, Pallavicini, Carla, Sanz, Camila, Tagliazucchi, Enzo Rodolfo, Zamberlan, Federico   +6 more
core   +2 more sources

Impact of a GABA‐Producing Lactococcus lactis on Microbiota and Mycobiota During CNS Inflammatory Demyelination

FASEB BioAdvances, Volume 8, Issue 1, January 2026.
GABA‐producing Lactococcus lactis protects against experimental autoimmune encephalomyelitis (EAE) in a mouse source‐dependent manner. The study focuses on the therapeutic potential of genetically engineered gamma‐aminobutyric acid (GABA)‐overproducing Lactococcus lactis (P8s‐GAD L. lactis) in the EAE model.
Kristina Hill, Alexandra LaFollette, Trevor O. Kirby, Soledad Negrete, Dani Babcock, Kari Felton, Hannah Kohl, Kavita Sharma, Andrea Castillo, Jean‐Baptiste Roullet, K. Michael Gibson, Javier Ochoa‐Repáraz   +11 more
wiley   +1 more source

Alcohol and the endocrine system: A critical review of disruptions, potential mechanisms, and health implications

Alcohol, Clinical and Experimental Research, Volume 50, Issue 1, January 2026.
The endocrine system coordinates whole body cellular function and maintains homeostasis. Alcohol impacts the integrity of endocrine regulation at multiple sites, contributing to risk for comorbidities. Some of the alcohol‐mediated pathophysiological effects on the endocrine system include alterations in receptor expression and responsiveness, protein ...
Patricia E. Molina, Liz Simon
wiley   +1 more source

Interactions between the neuromodulatory systems and the amygdala: exploratory survey using the Allen Mouse Brain Atlas. [PDF]

, 2013
Neuromodulatory systems originate in nuclei localized in the subcortical region of the brain and control fundamental behaviors by interacting with many areas of the central nervous system.
Krichmar, Jeffrey L, Zaldivar, Andrew
core   +1 more source

Cholinergic Regulation of hnRNPA2/B1 Translation by M1 Muscarinic Receptors [PDF]

The Journal of Neuroscience, 2016
Cholinergic vulnerability, characterized by loss of acetylcholine (ACh), is one of the hallmarks of Alzheimer's disease (AD). Previous work has suggested that decreased ACh activity in AD may contribute to pathological changes through global alterations in alternative splicing.
Benjamin Kolisnyk, Mohammed A. Al-Onaizi, Jason Xu, Gustavo M. Parfitt, Valeriy G. Ostapchenko, Geula Hanin, Hermona Soreq, Marco A. M. Prado, Vania F. Prado   +8 more
openaire   +4 more sources

State‐dependent regulation of the Kv7.2 channel voltage sensor by QO‐58

British Journal of Pharmacology, Volume 183, Issue 2, Page 333-348, January 2026.
Background and Purpose KV7(KCNQ) potassium channels are key modulators of neuronal excitability, and promising targets for development of drugs for epilepsy and pain. We investigated a candidate KV7 drug, QO‐58, which has been previously described but has an unclear mechanism of action.
Richard Kanyo, Shawn M. Lamothe, Thomas M. Hammond, Harley T. Kurata   +3 more
wiley   +1 more source

Ligand-guided homology modeling drives identification of novel histamine H3 receptor ligands [PDF]

, 2019
In this study, we report a ligand-guided homology modeling approach allowing the analysis of relevant binding site residue conformations and the identification of two novel histamine H3 receptor ligands with binding affinity in the nanomolar range.
Hagenow, Stefanie, Schaller, David, Stark, Holger, Wolber, Gerhard   +3 more
core   +2 more sources