Results 121 to 130 of about 22,962 (264)

A New Era of Muscarinic Acetylcholine Receptor Modulators in Neurological Diseases, Cancer and Drug Abuse

Pharmaceuticals
The cholinergic pathways in the central nervous system (CNS) play a pivotal role in different cognitive functions of the brain, such as memory and learning.
Helena Tsimpili, Grigoris Zoidis
doaj   +1 more source

Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors

Neurobiology of Disease, 2015
Clinical studies demonstrate that scopolamine, a non-selective muscarinic acetylcholine receptor (mAchR) antagonist, produces rapid therapeutic effects in depressed patients, and preclinical studies report that the actions of scopolamine require ...
Andrea Navarria, Eric S. Wohleb, Bhavya Voleti, Kristie T. Ota, Sophie Dutheil, Ashley E. Lepack, Jason M. Dwyer, Manabu Fuchikami, Astrid Becker, Filippo Drago, Ronald S. Duman   +10 more
doaj   +1 more source

M₁ muscarinic receptor activation decreases alcohol consumption via a reduction in consummatory behavior. [PDF]

Pharmacol Res Perspect, 2022
Walker LC, Campbell EJ, Huckstep KL, Chen NA, Langmead CJ, Lawrence AJ.   +5 more
europepmc   +1 more source

Developing muscarinic receptor M1 classification models utilizing transfer learning and generative AI techniques

Scientific Reports
Muscarinic receptor subtype 1 (M1) is a G protein-coupled receptor (GPCR) and a key pharmacological target for peripheral neuropathy, chronic obstructive pulmonary disease, nerve agent exposures, and cognitive disorders.
Souvik Dey, Anders Wallqvist, Mohamed Diwan M. AbdulHameed   +2 more
doaj   +1 more source

Agonist‐induced down‐regulation of m1 muscarinic receptors and reduction of their mRNA level in a transfected cell line [PDF]

, 1990
Shou Zhen Wang, Jingru Hu, Rochelle M. Long, Wanida S. Pou, Carlos Forray, Esam E. El‐Fakahany   +5 more
openalex   +1 more source

Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs. [PDF]

Nat Chem Biol, 2020
Bradley SJ, Molloy C, Valuskova P, Dwomoh L, Scarpa M, Rossi M, Finlayson L, Svensson KA, Chernet E, Barth VN, Gherbi K, Sykes DA, Wilson CA, Mistry R, Sexton PM, Christopoulos A, Mogg AJ, Rosethorne EM, Sakata S, John Challiss RA, Broad LM, Tobin AB.   +21 more
europepmc   +1 more source

P2Y₂ Nucleotide Receptors Expressed Heterologously in Sympathetic Neurons Inhibit Both N-Type Ca²⁺ and M-Type K⁺ Currents [PDF]

, 1998
The P2Y₂ receptor is a uridine/adenosine triphosphate (UTP/ATP)-sensitive G-protein-linked nucleotide receptor that previously has been reported to stimulate the phosphoinositide signaling pathway.
Barnard, EA, Brown, DA, Filippov, AK, Webb, TE   +3 more
core  

Preparation of a First 18F-Labeled Agonist for M1 Muscarinic Acetylcholine Receptors [PDF]

, 2020
Boris D. Zlatopolskiy, Felix Neumaier, Till Rüngeler, Birte Drewes, Niklas Kolks, Bernd Neumaier   +5 more
openalex   +1 more source

Mechanistic Clues Provided by Concurrent Changes in the Expression of Genes Encoding the M₁ Muscarinic Receptor, β-Catenin Signaling Proteins, and Downstream Targets in Adenocarcinomas of the Colon. [PDF]

Front Physiol, 2022
Alizadeh M, Schledwitz A, Cheng K, Raufman JP.   +3 more
europepmc   +1 more source

Activity-dependent expression and distribution of M1 muscarinic ACh receptors in visual cortex neuronal cultures [PDF]

, 1994
Yuzhuo Wang, Qiang Gu, Fei Mao, RP Haugland, M. Cynader   +4 more
openalex   +1 more source